Harnessing Phase Separation for the Development of High‐Performance Hydrogels
Advanced Science, EarlyView.ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao +3 more
wiley +1 more source
Amniotic fluid embolism complicated by pulmonary embolism leading to multiple organ dysfunction: case report. [PDF]
Front Med (Lausanne)Liu M +5 more
europepmc +1 more source
Advanced Science, EarlyView.Compared to a healthy random nanofibrous fibronectin microenvironment, a fibrotic aligned nanofibrous fibronectin microenvironment employs a specific integrin, α5β1 integrin, to activate early pro‐fibrotic fibroblast behaviors and later fibrotic fibroblast tissue formation with cell/F‐actin alignment, α‐SMA expression, and cell‐driven aligned ...
Doğuhan Beyatlı +3 more
wiley +1 more source
Hedgehog pathway disruption alters urothelial differentiation and continence mechanisms in the female mouse lower urinary tract. [PDF]
Am J Physiol Renal PhysiolTanaka LF +13 more
europepmc +1 more source
Advanced Science, EarlyView.ABSTRACT Engineered ascorbate peroxidase APEX2 has been widely used for spatially restricted profiling of subcellular biomolecules, but its catalytic efficiency toward newly developed probes such as biotin‐aniline (Btn‐An) remains suboptimal. To overcome this limitation, we performed yeast surface display‐based directed evolution to enhance APEX2 ...
Gang Wang, Yi Li, Peiyuan Meng, Peng Zou
wiley +1 more source
Human iPSCs: atrial versus ventricular cardiomyocytes and their functional and pharmacological differences. [PDF]
Biochem Soc TransBroadbent SD +3 more
europepmc +1 more source
Soft and Adhesive Cardiac Patch for Electrophysiological and Contraction Measurement
Advanced Science, EarlyView.This study developed an epicardial electronic patch with a modulus similar to that of the heart (approximately 65kPa), which can collect stable electrocardiogram signals and myocardial contractility on the surface of a dynamically beating heart. This is attributed to the hydrogen bond interaction formed between the amino and catechol groups in the ...
Wuliang Chen +10 more
wiley +1 more source
Homeometric autoregulation in severe aortic stenosis: insights from transcatheter aortic valve replacement. [PDF]
Front Cardiovasc MedDoerr AJ +5 more
europepmc +1 more source
Sono‐Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology
Advanced Science, EarlyView.Sono‐mechanogenetics links ultrasound physics with cellular mechanotransduction to enable noninvasive control of engineered biological systems. Acoustic forces generate distinct deformation modes that activate intracellular signaling pathways, which can be coupled to synthetic gene circuits to regulate diverse cellular functions, including gene ...
Yunjia Qu +4 more
wiley +1 more source
<i>Ex-vivo</i> culture of human hypertrophic cardiomyopathy hearts: Functional and metabolic changes during long-term culture. [PDF]
iScienceNassar A +11 more
europepmc +1 more source