Results 31 to 40 of about 331,435 (254)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

An in vivo probabilistic atlas of the human locus coeruleus at ultra-high field

NeuroImage, 2021
Early and profound pathological changes are evident in the locus coeruleus (LC) in dementia and Parkinson's disease, with effects on arousal, attention, cognitive and motor control.
Rong Ye, Catarina Rua, Claire O'Callaghan, P. Simon Jones, Frank H. Hezemans, Sanne S. Kaalund, Kamen A. Tsvetanov, Christopher T. Rodgers, Guy Williams, Luca Passamonti, James B. Rowe   +10 more
doaj   +1 more source

Comparison of contrast-to-noise ratios of different detection methods in ultrasound optical tomography

Biomedical Optics Express, 2022
Ultrasound optical tomography (UOT) is a hybrid imaging modality based on interaction between ultrasound and light, with a potential to extend optical imaging capabilities in biological tissues to depths of several centimeters. Several methods have been developed to detect the UOT signal. To better understand their potential for deep tissue imaging, we
Alexander Bengtsson, David Hill, Kevin Shortiss, Lars Rippe, Stefan Kröll   +4 more
openaire   +2 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Preliminary study on the feasibility of united compressed sensing with radial acquisition as a routine method for liver dynamic contrast-enhanced examination in elderly patients with malignancy

Insights into Imaging
Objective To explore the value of the united imaging compressed sensing with radial acquisition (uCSR) in liver dynamic contrast-enhanced examinations for elderly patients with malignancy.
Heping Deng, Xiaolei Dong, Yu Zhang, Peng Zhou, Yakun He, Liu Yang   +5 more
doaj   +1 more source

Optimisation of the bone single photon emission computed tomography in oncology patients

Journal of Health Sciences
Introduction: The introduction of hybrid imaging systems such as Single Photon Emission Computed Tomography/Computed Tomography (SPECT/CT) has completely changed the scanning procedure of conventional diagnostic nuclear medicine protocols.
Nusret Salkica, Amela Begić, Adnan Beganović, Fuad Julardžija, Adnan Šehić, Halil Ćorović, Safet Hadžimusić, Amra Skopljak-Beganović   +7 more
doaj   +1 more source

Application of Computed Tomography Virtual Noncontrast Spectral Imaging in Evaluation of Hepatic Metastases: A Preliminary Study

Chinese Medical Journal, 2015
Objective: The objective was to qualitatively and quantitatively evaluate hepatic metastases using computed tomography (CT) virtual noncontrast (VNC) spectral imaging in a retrospective analysis.
Shi-Feng Tian, Ai-Lian Liu, Jing-Hong Liu, Mei-Yu Sun, He-Qing Wang, Yi-Jun Liu   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Super-resolution deep learning reconstruction at coronary computed tomography angiography to evaluate the coronary arteries and in-stent lumen: an initial experience

BMC Medical Imaging, 2023
A super-resolution deep learning reconstruction (SR-DLR) algorithm trained using data acquired on the ultrahigh spatial resolution computed tomography (UHRCT) has the potential to provide better image quality of coronary arteries on the whole-heart ...
Makoto Orii, Misato Sone, Takeshi Osaki, Yuta Ueyama, Takuya Chiba, Tadashi Sasaki, Kunihiro Yoshioka   +6 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source