Results 51 to 60 of about 2,242,967 (259)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Resolution Comparison of a Standoff Gel Pad Versus a Liquid Gel Barrier for Nasal Bone Fracture Sonography: A Standardized Crossover Study

Diagnostics
Background: High-frequency ultrasonography (US) is increasingly used to guide closed reduction in nasal bone fractures, but near-field resolution over the curved nasal dorsum depends critically on the acoustic coupling medium.
Dong Gyu Kim, Kyung Ah Lee
doaj   +1 more source

Lesion-to-liver contrast-to-noise ratio (CNR) for HCCs.

, 2016
Box-and-whisker plots showing the median (middle line of each box), quartiles (top and bottom lines of each box), and upper and lower adjacent (upper and lower whiskers for each box) values of the lesion-to-liver contrast-to-noise ratio (CNR) for HCCs ...
Eun-Suk Cho (804566), Joo Hee Kim (804567), Jeong-Sik Yu (804568), Dae Jung Kim (629148), Jae-Joon Chung (804569), Inhwan Jeon (3391028)   +5 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Optical coherence tomography with enhanced contrast using oriented magnetic nanorods [PDF]

Frontiers of Optoelectronics
In recent years, the utilization of nanoparticles with varying morphologies in optical coherence tomography (OCT) has gained prominence, primarily aimed at enhancing imaging contrast and depth.
Seyyede Sarvenaz Khatami, Mohammad Ali Ansari, Behnam Shariati Bein Kalaee, Valery V. Tuchin   +3 more
doaj   +1 more source

Automatic Quantification of Local Plaque Thickness Differences as Assessed by Serial Coronary Computed Tomography Angiography Using Scan-Quality-Based Vessel-Specific Thresholds

Cardiology and Therapy, 2023
Introduction The use of serial coronary computed tomography angiography (CCTA) allows for the early assessment of coronary plaque progression, a crucial factor in averting major adverse cardiac events (MACEs). Traditionally, serial CCTA is assessed using
Finn Y. van Driest, Alexander Broersen, Rob J. van der Geest, J. Wouter Jukema, Arthur J. H. A. Scholte, Jouke Dijkstra   +5 more
doaj   +1 more source

The Quantitative Effect of Noise and Object Diameter on Low-Contrast Detectability of AAPM CT Performance Phantom Images

Atom Indonesia, 2023
Parameters for determining computed tomography (CT) image quality include noise and low-contrast detectability. Studies on low-contrast detectability using the AAPM CT performance phantom have several limitations, such as the absence of quantitative ...
E. Setiawati, C. Anam, W. Widyasari, G. Dougherty   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A Dual-Transducer Approach for High-Resolution and High-Precision Shear Wave Elasticity Imaging

Sensors
Shear wave elasticity imaging, an ultrasound-based method for imaging tissue elasticity, has been widely accepted in both preclinical studies and clinical practices for diagnosing various diseases.
Jingfei Liu, Stanislav Y. Emelianov
doaj   +1 more source