Results 111 to 120 of about 6,785,321 (317)

Contrast agents and renal cell apoptosis

, 2008
Contrast media (CM) induce a direct toxic effect on renal tubular cells. This toxic effect may have a role in the pathophysiology of contrast nephropathy.
Romano, Giulia
core  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Investigating the significance of multiple scattering in ultrasound contrast agent particle populations

, 2005
The majority of the existing models describing the behavior of microbubble ultrasound contrast agents consider single, isolated microbubbles suspended in infinite media.
N. Saffari, Stride, E, E. Stride, Saffari, N   +3 more
core   +1 more source

2015 Update on Acute Adverse Reactions to Gadolinium based Contrast Agents in Cardiovascular MR. Large Multi-National and Multi-Ethnical Population Experience With 37788 Patients From the EuroCMR Registry [PDF]

, 2015
Objectives: Specifically we aim to demonstrate that the results of our earlier safety data hold true in this much larger multi-national and multi-ethnical population.
Pilz, G., Nothnagel, D., Schneider, S., Sechtem, U, Sechtem, U., Pilz, G, van Rossum, AC, Nagel, E, Greulich, S., Rossum, A.C., Buss, Sebastian, Schwitter, J., Lombardi, M., Greulich, S, Lombardi, M, Wagner, A, Wagner, A., Bruder, O, Buss, S, Mahrholdt, H, Nothnagel, D, Bruder, O., Schwitter, J, Petersen, S., Jensen, C., Jensen, C, Buss, S., Mahrholdt, H., Nagel, E., Schneider, S, van Rossum, A.C., Petersen, S   +31 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

An Efficient Multiclass Medical Image CBIR System Based on Classification and Clustering

Journal of Intelligent Systems, 2018
In this paper, we are going to present the multiclass medical image content-based image retrieval (CBIR) system based on classification and clustering.
Kabbur Mahabaleshwar S.
doaj   +1 more source

Contrast-Independent Biologically Inspired Motion Detection

, 2011
Babies B, Lindemann JP, Egelhaaf M, Möller R. Contrast-Independent Biologically Inspired Motion Detection. Sensors. 2011;11(12):3303-3326.Optic flow, i.e., retinal image movement resulting from ego-motion, is a crucial source of information used for ...
Lindemann, Jens Peter ; https://orcid.org/, Egelhaaf, Martin ; https://orcid.org/, Martin Egelhaaf, Jens Peter Lindemann, Ralf Möller, Birthe Babies, Möller, Ralf ; https://orcid.org/, Babies, Birthe   +7 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Contrast-enhanced micro-CT imaging.

, 2017
(a) Micro-CT section of an unstained and (b) an iodine-stained optic nerve. In the case of the unstained optic nerve (control) none of the anatomical substructures were distinguishable with micro-CT, since density variations within soft tissue are very ...
Christian Enders (3700567), Eva-Maria Braig (3700561), Franz Pfeiffer (288057), Peter Noël (2579098), Ernst Rummeny (437045), Julia Herzen (394748), Gabriele E. Lang (3700564), Gerhard K. Lang (3700573), Kai Scherer (563503), Jens U. Werner (3700570)   +9 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source