Bisindole Compounds—Synthesis and Medicinal Properties [PDF]
AntibioticsThe indole nucleus stands out as a pharmacophore, among other aromatic heterocyclic compounds with remarkable therapeutic properties, such as benzimidazole, pyridine, quinoline, benzothiazole, and others.
Maria Marinescu
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One‐Pot Synthesis of Novel β‐Carboline‐{α‐Acylaminoamide}‐Bisindole Derivatives: Antibacterial Evaluation, Molecular Docking, and Density Functional Theory Studies [PDF]
ChemistryOpenA new series of β‐carboline‐{α‐acylaminoamide}‐bisindole hybrids (12a–l) is designed and synthesized employing an atom‐economical one‐pot Ugi four‐component reaction (U‐4CR), affording the target compounds in good yields. All synthesized compounds (12a–l)
Ankit Kumar Atri +8 more
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Bio-informed synthesis of marine-sourced indole derivatives: suppressing gram-negative bacteria biofilm and virulence [PDF]
BMC BiologyBiofilms cling to surfaces to form complex architectures allowing their bacterial creators to acquire multidrug resistance and claiming countless lives worldwide.
Karina Golberg +9 more
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Marine-Derived Bisindoles for Potent Selective Cancer Drug Discovery and Development [PDF]
MoleculesMarine-derived bisindoles exhibit structural diversity and exert anti-cancer influence through multiple mechanisms. Comprehensive research has shown that the development success rate of drugs derived from marine natural products is four times higher than
Mengwei Xu +9 more
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Exploring hydrophilic 2,2-di(indol-3-yl)ethanamine derivatives against Leishmania infantum. [PDF]
PLoS ONEHerein we report the design and the synthesis of a library of new and more hydrophilic bisindole analogues based on our previously identified antileishmanial compound URB1483 that failed the preliminary in vivo test.
Alessia Centanni +10 more
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Synthesis and biological activity of bisindole derivatives as novel MARK4 inhibitors
European Journal of Medicinal Chemistry Reports, 2022 Bisindole alkaloids are well-known bioactive natural products presenting numerous pharmacological properties. Following the indolocarbazole biosynthetic pathway a series of bisindole derivatives were synthesized and their activity against MARK4 kinase ...
Maria Voura +7 more
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Dimethyl 3,3′-[(4-nitrophenyl)methylene]bis(1H-indole-2-carboxylate) ethanol hemisolvate
IUCrData, 2021 There are two main molecules in asymmetric unit of the title compound, C27H21N3O6·0.5C2H5OH. In both, the indole ring systems are approximately perpendicular to each other, at dihedral angles of 69.3 (5) and 82.8(4)°. In the crystal, molecules are linked
Yu-Long Li +6 more
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Novel Small-Molecule Hybrid-Antibacterial Agents against S. aureus and MRSA Strains
Molecules, 2021 Ongoing resistance developments against antibiotics that also affect last-resort antibiotics require novel antibacterial compounds. Strategies to discover such novel structures have been dimerization or hybridization of known antibacterial agents.
Robin Gehrmann +5 more
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Diethyl 3,3′-[(3-fluorophenyl)methylene]bis(1H-indole-2-carboxylate)
IUCrData, 2020 In the title compound, C29H25FN2O4, the mean planes of the indole ring systems are approximately perpendicular to one another [dihedral angle = 88.3 (4)°]. The benzene ring is twisted with respect to the indole ring systems by 49.8 (5) and 77.6 (3)°.
Hong Jiang +7 more
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Beilstein Journal of Organic Chemistry, 2021 Two or more indole molecules tailored to a single non-metal central atom, through any of their C2–7 positions are not only structurally engaging but also constitute a class of important pharmacophores.
Ranadeep Talukdar
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