Results 1 to 10 of about 1,976 (139)

Bisindole Compounds—Synthesis and Medicinal Properties [PDF]

Antibiotics
The indole nucleus stands out as a pharmacophore, among other aromatic heterocyclic compounds with remarkable therapeutic properties, such as benzimidazole, pyridine, quinoline, benzothiazole, and others.
Maria Marinescu
doaj   +3 more sources

One‐Pot Synthesis of Novel β‐Carboline‐{α‐Acylaminoamide}‐Bisindole Derivatives: Antibacterial Evaluation, Molecular Docking, and Density Functional Theory Studies [PDF]

ChemistryOpen
A new series of β‐carboline‐{α‐acylaminoamide}‐bisindole hybrids (12a–l) is designed and synthesized employing an atom‐economical one‐pot Ugi four‐component reaction (U‐4CR), affording the target compounds in good yields. All synthesized compounds (12a–l)
Ankit Kumar Atri, Lavanya Khullar, Gobind Kumar, Sahil Mishra, Tamanna Dua, Vinay Singh, Kusum Harjai, Parvesh Singh, Vasundhara Singh   +8 more
doaj   +3 more sources

Rapid Access to an Enantioenriched Spiro Bisindole Directly from Indole and Acetone. [PDF]

Angew Chem Int Ed Engl
Disclosed here is a “one‐pot self‐assembly” strategy for the enantioselective synthesis of a spiro bisindole molecule directly from indole and acetone.
Wang JY, Lin J, Zhang C, Sun J.
europepmc   +2 more sources

Stereochemical Analysis of Natural Products: Bisindole Alkaloids of the <i>Strychnos-Strychnos</i> Type. [PDF]

Int J Mol Sci
Results of the high-level computational study of 12 bisindole alkaloids of the Strychnos-Strychnos type are reported in addition of that of five retuline-like monomers frequently encountered in moieties constituting dimeric alkaloids.
Grigoriev DA, Semenov VA, Angenot L, Krivdin LB.   +3 more
europepmc   +2 more sources

NaHMDS/B(C₆F₅)₃-promoted diastereoselective Friedel-Crafts alkylation of indoles/pyrroles with <i>N-tert</i>-butanesulfinylimines: towards the asymmetric synthesis of bisindole alkaloid Calcicamide B. [PDF]

RSC Adv
This study proposed an innovative and pragmatic approach to the asymmetric Friedel–Crafts reaction by employing indoles/pyrroles and chiral N-tert-butanesulfinylimines promoted by NaHMDS/B(C6F5)3.
Zhang G, Chen X, Liu Y, Peng R, Xu M, Yan S, Xiao J, Liu Z, Min Q, Liao G, Wang X, Qin S.   +11 more
europepmc   +2 more sources

Bio-informed synthesis of marine-sourced indole derivatives: suppressing gram-negative bacteria biofilm and virulence [PDF]

BMC Biology
Biofilms cling to surfaces to form complex architectures allowing their bacterial creators to acquire multidrug resistance and claiming countless lives worldwide.
Karina Golberg, Kamal Elouarzaki, Bat-el Kagan, Marilou Shagan, Netta Shemesh, Esti Kramarsky-Winter, Anat Ben-Zvi, Yaffa Mizrachi Nebenzahl, Robert S. Marks, Ariel Kushmaro   +9 more
doaj   +2 more sources

Structure of methyltransferase RedM that forms the dimethylpyrrolinium of the bisindole reductasporine. [PDF]

J Biol Chem, 2023
Bisindoles are biologically active natural products that arise from the oxidative dimerization of two molecules of l-tryptophan. In bacterial bisindole pathways, a core set of transformations is followed by the action of diverse tailoring enzymes that ...
Daniel-Ivad P, Ryan KS.
europepmc   +2 more sources

Marine-Derived Bisindoles for Potent Selective Cancer Drug Discovery and Development [PDF]

Molecules
Marine-derived bisindoles exhibit structural diversity and exert anti-cancer influence through multiple mechanisms. Comprehensive research has shown that the development success rate of drugs derived from marine natural products is four times higher than
Mengwei Xu, Zhaofang Bai, Baocheng Xie, Rui Peng, Ziwei Du, Yan Liu, Guangshuai Zhang, Si Yan, Xiaohe Xiao, Shuanglin Qin   +9 more
doaj   +2 more sources

Discovery of potent bisindole-based pyrazolopyridine derivatives as topoisomerase inhibitors: DNA damage induction and synergistic antileukemic activity. [PDF]

Front Pharmacol
Introduction The development of novel anticancer agents targeting DNA replication and repair mechanisms remains a priority in leukemia therapy. In this study, newly synthesized derivatives incorporating bis-indole and pyrazolo[3,4-b]pyridine scaffolds ...
Eldehna WM, Tawfik HO, Veselá D, Peřina M, Negmeldin AT, Elsayed ZM, Majrashi TA, Vojáčková V, Elbadawi MM, Shaldam MA, Kryštof V, Abdel-Aziz HA.   +11 more
europepmc   +2 more sources

Synthesis and biological activity of bisindole derivatives as novel MARK4 inhibitors

European Journal of Medicinal Chemistry Reports, 2022
Bisindole alkaloids are well-known bioactive natural products presenting numerous pharmacological properties. Following the indolocarbazole biosynthetic pathway a series of bisindole derivatives were synthesized and their activity against MARK4 kinase ...
Maria Voura, Saleha Anwar, Savvas Thysiadis, Parvez Κhan, Panagiotis Dalezis, Dimitrios T. Trafalis, Md Imtaiyaz Hassan, Vasiliki Sarli   +7 more
doaj   +1 more source