Results 31 to 40 of about 1,055 (166)
Synthesis of New Methoxy Actived Mono and Bis-indole Compounds
Hittite Journal of Science and Engineering, 2022 An indole hydrazone has successfully been synthesized employing Schiff base reaction conditions starting from 4,6-dimethoxy-2,3-diphenylindole-7-carbaldehyde with hydrazine hydrate.
Hakan Kandemir
doaj +1 more source
Bisindole alkaloids from Voacanga grandifolia leaves
Journal of Natural Medicines, 2021 Two new bisindole alkaloids, 12'-O-demethyl-vobtusine-5-lactam and isovobtusine-N-oxide (1 and 2), were isolated from the leaves of Voacanga grandifolia, together with two known bisindole alkaloids. Their structures were elucidated on the basis of 1D and 2D NMR data. 1 and 2 showed potent antimalarial activity against Plasmodium falciparum 3D7 and very
Alfarius Eko Nugroho, - +10 more
openaire +3 more sources
Microorganisms, 2019 The antimicrobial activity of the marine bisindole alkaloid 2,2-bis(6-bromo-3-indolyl) ethylamine (1) and related synthetic analogues (compounds 2⁻8) against target microorganisms was investigated by Minimum Inhibitory Concentration (MIC ...
Raffaella Campana +3 more
doaj +1 more source
Applied Microbiology, 2023 Heterocyclic compounds can specifically regulate bacterial development by targeting specific bacterial enzymes and metabolic pathways. The ESKAPE pathogens are multidrug-resistant and cause nosocomial infections, which is one of the greatest challenges ...
Lisha K. Poonacha +12 more
doaj +1 more source
Bioactive Bis(indole) Alkaloids from a Spongosorites sp. Sponge
Marine Drugs, 2020 Six new bis(indole) alkaloids (1–6) along with eight known ones of the topsentin class were isolated from a Spongosorites sp. sponge of Korea. Based on the results of combined spectroscopic analyses, the structures of spongosoritins A–D (1–4) were ...
Jae Sung Park +9 more
doaj +1 more source
Cloning and Overexpression of Strictosidine β-D-Glucosidase Gene Short Sequence from Catharanthus roseus in Escherichia coli [PDF]
Advanced Pharmaceutical Bulletin, 2019 Purpose: Strictosidine-β-D-glucosidase (SGD) is considered as a key enzyme in the production of bisindole alkaloids in Catharanthus roseus. The present study illustrated the production of a short sequence of this enzyme in Escherichia coli without codon ...
Ahmed Saeed Arafa +4 more
doaj +1 more source
Marine bisindole alkaloid: A potential apoptotic inducer in human cancer cells
European Journal of Histochemistry, 2018 Marine organisms such as corals, sponges and tunicates produce active molecules which could represent a valid starting point for new drug development processes.
Sara Salucci +8 more
doaj +1 more source
Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 8, Page 1529-1540, August 2026.ABSTRACT BorF is a short‐chain flavin reductase from a desert soil bacterium that uses NADH to reduce FAD to FADH2, which is used by the tryptophan‐6‐halogenase BorH to chlorinate tryptophan in the biosynthetic pathway of borregomycin A. The X‐ray crystal structure of BorF bound to FAD was solved to 2.37 Å by molecular replacement.
Zheng Ma +3 more
wiley +1 more source
Oxidative Rearrangements of the Alkaloid Intermediate Geissoschizine
Angewandte Chemie, Volume 137, Issue 24, June 10, 2025.19E‐geissoschizine is a key precursor in the biosynthesis of monoterpene indole alkaloids such as strychnine, ibogaine, and vinblastine. Using enzymatic assays and gene silencing, three CYPs were identified from C. roseus that oxidize this compound to four alkaloid scaffolds: strychnos, sarpagan, akuammiline, and mavacurane. Mutational analysis reveals
Mohamed O. Kamileen +6 more
wiley +2 more sources
Marine Drugs, 2019 The composition of the culture medium has great influence on the metabolite production of the marine fungus Pseudallescheria boydii F44-1. By adding amino acids to GPY culture medium, two new bisindole alkaloids, pseudboindoles A and B (1 and 2 ...
Mei-Xiang Yuan +7 more
doaj +1 more source