Results 41 to 50 of about 1,592 (193)

Antemitotic activity of strychnopentamine, a bisindolic alkaloid

Journal of Ethnopharmacology, 1984
Strychnopentamine has been tested for its cytotoxic and antitumor activities and compared with two other bisindolic alkaloids that possess an usambarane skeleton. The presence of a N-methylpyrrolidine group increases the antimitotic activity of this type of alkaloids.
Tits, Monique, Desaive, Claude, Marnette, J. M., Bassleer, Roger, Angenot, Luc   +4 more
openaire   +3 more sources

A Fluorinated Analogue of Marine Bisindole Alkaloid 2,2-Bis(6-bromo-1H-indol-3-yl)ethanamine as Potential Anti-Biofilm Agent and Antibiotic Adjuvant Against Staphylococcus aureus

Pharmaceuticals, 2020
Methicillin resistant Staphylococcus aureus (MRSA) infections represent a major global healthcare problem. Therapeutic options are often limited by the ability of MRSA strains to grow as biofilms on medical devices, where antibiotic persistence and ...
Raffaella Campana, Gianmarco Mangiaterra, Mattia Tiboni, Emanuela Frangipani, Francesca Biavasco, Simone Lucarini, Barbara Citterio   +6 more
doaj   +1 more source

Isatin Bis-Indole and Bis-Imidazothiazole Hybrids: Synthesis and Antimicrobial Activity

Molecules, 2022
Isatin and its derivatives are important heterocycles found in nature and present in numerous bioactive compounds which possess various biological activities. Moreover, it is an essential building block in organic synthesis.
Francesca Bonvicini, Alessandra Locatelli, Rita Morigi, Alberto Leoni, Giovanna Angela Gentilomi   +4 more
doaj   +1 more source

Crystal structure of diethyl 3,3′-[(2,4-dichlorophenyl)methylidene]bis(1H-indole-2-carboxylate)

Acta Crystallographica Section E: Crystallographic Communications, 2017
In the title compound, C29H24Cl2N2O4, the mean planes of the two indole ring systems (r.m.s. deviations = 0.1249 and 0.0075 Å) are approximately perpendicular to one another, with a dihedral angle of 80.9 (5)° between them.
Yu-Long Li, Hong-Shun Sun, Hong Jiang, Yu-Liang Chen, Yang-Feng Chen   +4 more
doaj   +1 more source

An Alkaloid from a Highly Invasive Seaweed Increases the Voracity and Reproductive Output of a Model Fish Species

Marine Drugs, 2022
The invasive macroalga Caulerpa cylindracea has spread widely in the Mediterranean Sea, becoming a favorite food item for native fish for reasons yet unknown.
Valentina Schiano, Adele Cutignano, Daniela Maiello, Marianna Carbone, Maria Letizia Ciavatta, Gianluca Polese, Federica Fioretto, Chiara Attanasio, Antonio Palladino, Serena Felline, Antonio Terlizzi, Livia D’Angelo, Paolo de Girolamo, Mimmo Turano, Carla Lucini, Ernesto Mollo   +15 more
doaj   +1 more source

Synthesis of New Methoxy Actived Mono and Bis-indole Compounds

Hittite Journal of Science and Engineering, 2022
An indole hydrazone has successfully been synthesized employing Schiff base reaction conditions starting from 4,6-dimethoxy-2,3-diphenylindole-7-carbaldehyde with hydrazine hydrate.
Hakan Kandemir
doaj   +1 more source

Marine Alkaloid 2,2-Bis(6-bromo-3-indolyl) Ethylamine and Its Synthetic Derivatives Inhibit Microbial Biofilms Formation and Disaggregate Developed Biofilms

Microorganisms, 2019
The antimicrobial activity of the marine bisindole alkaloid 2,2-bis(6-bromo-3-indolyl) ethylamine (1) and related synthetic analogues (compounds 2⁻8) against target microorganisms was investigated by Minimum Inhibitory Concentration (MIC ...
Raffaella Campana, Gianfranco Favi, Wally Baffone, Simone Lucarini   +3 more
doaj   +1 more source

Development of Novel Indole and Coumarin Derivatives as Antibacterial Agents That Target Histidine Kinase in S. aureus

Applied Microbiology, 2023
Heterocyclic compounds can specifically regulate bacterial development by targeting specific bacterial enzymes and metabolic pathways. The ESKAPE pathogens are multidrug-resistant and cause nosocomial infections, which is one of the greatest challenges ...
Lisha K. Poonacha, Rashmi Ramesh, Akshay Ravish, Arunkumar Mohan, Pradeep M. Uppar, Prashant K. Metri, Nanjunda Swamy Shivananju, Santosh L. Gaonkar, Shubha Gopal, Alexey Yu Sukhorukov, Vijay Pandey, Priya Babu Shubha, Basappa Basappa   +12 more
doaj   +1 more source

Bioactive Bis(indole) Alkaloids from a Spongosorites sp. Sponge

Marine Drugs, 2020
Six new bis(indole) alkaloids (1–6) along with eight known ones of the topsentin class were isolated from a Spongosorites sp. sponge of Korea. Based on the results of combined spectroscopic analyses, the structures of spongosoritins A–D (1–4) were ...
Jae Sung Park, Eunji Cho, Ji-Yeon Hwang, Sung Chul Park, Beomkoo Chung, Oh-Seok Kwon, Chung J. Sim, Dong-Chan Oh, Ki-Bong Oh, Jongheon Shin   +9 more
doaj   +1 more source

Ajmaline, Oxindole, and Cytotoxic Macroline–Akuammiline Bisindole Alkaloids from Alstonia penangiana

, 2018
Examination of the EtOH extract of the Malayan Alstonia penangiana resulted in the isolation of 10 new alkaloids, comprising two ajmaline (1, 2), four macroline oxindole (3–6), and four macroline–akuammiline bisindole alkaloids (7–10).
Suerialoasan Navanesan (785142), Kien-Thai Yong (4446481), Joanne Soon-Yee Yeap (5205269), Yun-Yee Low (1426531), Kae-Shin Sim (666138), Toh-Seok Kam (1426537), Subramaniam Gurusamy (5205272), Siew-Huah Lim (1426534)   +7 more
core   +3 more sources