Results 41 to 50 of about 1,055 (166)

Eight Indole Alkaloids from the Roots of Maerua siamensis and Their Nitric Oxide Inhibitory Effects

Molecules, 2022
Maerua siamensis (Capparaceae) roots are used for treating pain and inflammation in traditional Thai medicine. Eight new indole alkaloids, named maeruanitriles A and B, maeroximes A–C, and maeruabisindoles A–C, were isolated from them.
Sasiwimon Nukulkit, Angkana Jantimaporn, Preeyaporn Poldorn, Mattaka Khongkow, Thanyada Rungrotmongkol, Hsun-Shuo Chang, Rutt Suttisri, Chaisak Chansriniyom   +7 more
doaj   +1 more source

2,3‐Dichloro‐5,6‐Dicyano‐1,4‐Benzoquinone (DDQ)‐Mediated CC Bond Formation: Redox Strategies from Stoichiometric to Catalytic Systems

ChemistryOpen, Volume 15, Issue 4, April 2026.
2,3‐Dichloro‐5,6‐dicyano‐1,4‐benzoquinone serves as a versatile oxidant and redox catalyst for CC bond formation through hydride abstraction or single‐electron transfer. Stoichiometric and catalytic systems enable benzylic, allylic, and aromatic CH activation under mild, metal‐free conditions, providing sustainable routes to complex and bioactive ...
Dohoon Cha, Sun‐Joon Min
wiley   +1 more source

Synthesis, anti-leishmanial and molecular docking study of bis-indole derivatives

BMC Chemistry, 2019
We have synthesized new series of bisindole analogs (1–27), characterized by 1HNMR and HR-EI-MS and evaluated for their anti-leishmanial potential. All compounds showed outstanding inhibitory potential with IC50 values ranging from 0.7 ± 0.01 to 13.30 ...
Muhammad Taha, Imad Uddin, Mohammed Gollapalli, Noor Barak Almandil, Fazal Rahim, Rai Khalid Farooq, Muhammad Nawaz, Mohamed Ibrahim, Mohammed A. Alqahtani, Yasser A. Bamarouf, Manikandan Selvaraj   +10 more
doaj   +1 more source

From Racemic to Enantioselective Total Synthesis of Trigonoliimines via Development of an Organocatalytic Enantioselective Michael Addition of ?-Aryl-?-isocyanoacetate to Vinyl Phenyl Selenone

CHIMIA, 2014
Trigonoliimines are hexacyclic bisindole alkaloids isolated recently by Hao and co-workers. A synthesis of (±)-trigonoliimine B was accomplished in seven steps from simple starting materials featuring the Bischler-Napieralski reaction for ...
Thomas Buyck, Qian Wang, Jieping Zhu
doaj   +1 more source

Identification of Potential Therapeutic Agents for Primary Amebic Meningoencephalitis Using Text Mining and Bioinformatics Analyses

Analytical Cellular Pathology, Volume 2026, Issue 1, 2026.
Naegleria fowleri, the brain‐eating ameba, causes primary amebic meningoencephalitis (PAM), a fatal infectious disease that affects the central nervous system (CNS). We aimed to evaluate the functions and potential drugs targeting PAM using text mining and bioinformatics analyses.
Eun Jung Sohn, Hyeonseo Jo, Kun Taek Park, Andrey Elchaninov   +3 more
wiley   +1 more source

Ligand‐Based Pharmacophore Mapping and Virtual Screening for the Search of Biguanide‐Like Molecules With Antidiabetic Potentials Targeting Liver Kinase B1

Biochemistry Research International, Volume 2026, Issue 1, 2026.
Type 2 diabetes mellitus (T2DM) is a state where the body’s glucose metabolism is compromised. AMP‐activated protein kinase, or AMPK, has an important part to play in glucose metabolism, and the liver kinase B1 (LKB1) protein functions as a major upstream kinase for AMPK activation, thereby making it appealing therapeutic targets for treating and ...
Rumman Reza, Md. Nazmus Samdani, Niaz Morshed, Raihana Haque Jebin, Imtiaz Ahmed, Md. Selim Reza, Harleen Khatra   +6 more
wiley   +1 more source

Brominated Bisindole Alkaloids from the Celtic Sea Sponge Spongosorites calcicola

Molecules, 2019
As part of an ongoing program to identify new bioactive compounds from Irish marine bioresources, we selected the subtidal sponge Spongosorites calcicola for chemical study, as fractions of this species displayed interesting cytotoxic bioactivities and ...
Laurence K. Jennings, Neyaz M. D. Khan, Navdeep Kaur, Daniel Rodrigues, Christine Morrow, Aoife Boyd, Olivier P. Thomas   +6 more
doaj   +1 more source

Bisindole Alkaloids from the Alstonia Species: Recent Isolation, Bioactivity, Biosynthesis, and Synthesis

Molecules, 2021
Bisindoles are structurally complex dimers and are intriguing targets for partial and total synthesis. They exhibit stronger biological activity than their corresponding monomeric units.
Kamal P. Pandey, Md Toufiqur Rahman, James M. Cook   +2 more
doaj   +1 more source

Arenaria serpyllifolia as a Natural Antiviolaceum Agent: Phytochemical, Biological, and Molecular Approaches

ChemistryOpen, Volume 14, Issue 11, November 2025.
Arenaria serpyllifolia extract exhibits strong antioxidant, antimicrobial, antibiofilm, and antiquorum sensing activities. Key compounds, including levoglucosan and guanosine, show potent CviR receptor binding. Violacein inhibition and molecular dynamics confirm their stability, highlighting their potential as quorum sensing inhibitors and therapeutic ...
Meryem Burcu Külahcı, Betül Aydın, Emine Incilay Torunoğlu, Zekeriya Düzgün, Alper Durmaz, Erdi Can Aytar   +5 more
wiley   +1 more source

Structure-guided engineering of a flavin-containing monooxygenase for the efficient production of indirubin

Bioresources and Bioprocessing, 2022
Indirubin is a bisindole compound for the treatment of chronic myelocytic leukemia. Here, we presented a structure-guided method to improve the activity of a flavin-containing monooxygenase (bFMO) for the efficient production of indirubin in Escherichia ...
Bing-Yao Sun, Hua-Lu Sui, Zi-Wei Liu, Xin-Yi Tao, Bei Gao, Ming Zhao, Yu-Shu Ma, Jian Zhao, Min Liu, Feng-Qing Wang, Dong-Zhi Wei   +10 more
doaj   +1 more source