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The Chemistry of Grandifoline, a Bisindole Alkaloid
, 1979 Department of Pure Chemistry, University College of Science, 92, Acharya P. C.
(Mrs.) A. CHATTERJEE
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Molecules, 2016 Bisindole natural products consist of two monomeric indole alkaloid units as their obligate constituents. Bisindoles are more potent with respect to their biological activity than their corresponding monomeric units.
Md Toufiqur Rahman +2 more
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, 2006 Publisher Summary This chapter provides an overview on bisindole alkaloids. The indole–indole and tryptamine–tryptamine type, and related alkaloids are discussed. Tryptamine–tryptamine type with an additional monoterpene unit and related alkaloids are briefly discussed.
Toh-Seok Kam +3 more
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A new approach for the synthesis of bisindoles through AgOTf as catalyst [PDF]
Beilstein Journal of Organic Chemistry, 2014 A novel approach for the catalyzed formation of bisindolylmethane derivatives (BIMs) is described. This methodology is the unique example where AgOTf has been successfully used for the activation of aldehydes, giving easy access to a broad range of ...
Jorge Beltrá +2 more
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Design, Synthesis and Application of Chiral Spirocyclic Bisindoles
Angewandte Chemie, Volume 137, Issue 15, April 7, 2025.Chiral spirocyclic bisindoles have been designed and synthesized by asymmetric spirocyclization of the corresponding linear ketones by either chiral phosphoric acid catalysis or Rh‐catalyzed asymmetric arylation followed by simple Lewis acid catalysis.
Jing‐Yi Wang, Jianwei Sun
wiley +4 more sources
Efficient and Rapid Arylation of NH₂-Unprotected Bromobisindole Ethanamines via Suzuki-Miyaura Coupling: Generating New Leads Against Leishmania. [PDF]
ChemistryA library of novel bisindole derivatives was synthesized through an optimized rapid Suzuki‐Miyaura coupling reaction, utilizing NH2‐unprotected bromobisindole ethanamines and boronic acids with yields up to 93%. The compounds were screened for their activity against L. infantum promastigotes.
Buono A +8 more
europepmc +2 more sources
Bisindoles. 21. Synthesis and alkylation of some tetramethyl-substituted bisindoles [PDF]
Chemistry of Heterocyclic Compounds, 1985 2,3,2′,3′-Tetramethyl-substituted bisindoles and their 1,1′-dimethyl derivatives were synthesized. The latter were obtained in high yield by interphase alkylation of the bisindoles. The spectral characteristics of the synthesized bisindoles were studied.
M. G. Chesmaritashvili +6 more
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Combined Transcriptomic and Metabolomic Analysis Reveals an Ethylene-Activated Regulatory Model on Monoterpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus. [PDF]
Plant Biotechnol JABSTRACT Catharanthus roseus contains nearly 200 bioactive monoterpenoid indole alkaloids (MIAs) that are effective in treating cancer and other diseases. Ethylene plays a significant role in enhancing MIA biosynthesis, and we have found that it greatly induces the accumulation of anhydrovinblastine.
Deng B +9 more
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Synthesis and biological activity of bisindole derivatives as novel MARK4 inhibitors
European Journal of Medicinal Chemistry Reports, 2022 Bisindole alkaloids are well-known bioactive natural products presenting numerous pharmacological properties. Following the indolocarbazole biosynthetic pathway a series of bisindole derivatives were synthesized and their activity against MARK4 kinase ...
Maria Voura +7 more
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Dimethyl 3,3′-[(4-nitrophenyl)methylene]bis(1H-indole-2-carboxylate) ethanol hemisolvate
IUCrData, 2021 There are two main molecules in asymmetric unit of the title compound, C27H21N3O6·0.5C2H5OH. In both, the indole ring systems are approximately perpendicular to each other, at dihedral angles of 69.3 (5) and 82.8(4)°. In the crystal, molecules are linked
Yu-Long Li +6 more
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