Results 21 to 30 of about 1,797 (189)

Aspidospermatan–aspidospermatan and eburnane-sarpagine bisindole alkaloids from Leuconotis

, 2010
Leucofoline and leuconoline, representing the first members of the aspidospermatan–aspidospermatan and eburnane-sarpagine subclasses of the bisindole alkaloids, respectively, were isolated from the Malayan Leuconotis griffithii.
Komiyama, K., Kam, Toh Seok, Low, Y.Y., Robinson, W.T., Gan, C.Y.   +4 more
core   +6 more sources

Combined Transcriptomic and Metabolomic Analysis Reveals an Ethylene-Activated Regulatory Model on Monoterpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus. [PDF]

Plant Biotechnol J
ABSTRACT Catharanthus roseus contains nearly 200 bioactive monoterpenoid indole alkaloids (MIAs) that are effective in treating cancer and other diseases. Ethylene plays a significant role in enhancing MIA biosynthesis, and we have found that it greatly induces the accumulation of anhydrovinblastine.
Deng B, Miao Q, Ou C, Pan Y, Liu H, Fu X, Li L, Wang Y, Tang K, Pan Q.   +9 more
europepmc   +2 more sources

Catalyzed and uncatalyzed procedures for the syntheses of isomeric covalent multi-indolyl hetero non-metallides: an account

Beilstein Journal of Organic Chemistry, 2021
Two or more indole molecules tailored to a single non-metal central atom, through any of their C2–7 positions are not only structurally engaging but also constitute a class of important pharmacophores.
Ranadeep Talukdar
doaj   +1 more source

Octacycles and Nonacycles from 3Hydroxy-2,2-bisindole

, 2021
3-Hydroxy-2,2′-bisindole undergoes acid- and base-mediated dimerization–skeletal rearrangement processes, generating polyheterocyclic ring systems containing up to nine rings.
Jonathan Sperry (619935), Jonathan Sperry, Maurycy Prystupa (9749549), Tilo Söhnel, Tilo Söhnel (1463320), Maurycy Prystupa   +5 more
core   +1 more source

Discovery of Barakacin and Its Derivatives as Novel Antiviral and Fungicidal Agents

Molecules, 2023
Pesticides are essential for the development of agriculture. It is urgent to develop green, safe and efficient pesticides. Bisindole alkaloids have unique and concise structures and broad biological activities, which make them an important leading ...
Yongyue Gao, Xingxing He, Lili Yan, Hongyu Zhang, Sijia Liu, Qian Ma, Peiyao Zhang, Yan Zhang, Zijun Zhang, Ziwen Wang, Aidang Lu, Qingmin Wang   +11 more
doaj   +1 more source

Concise Syntheses of Marine (Bis)indole Alkaloids Meridianin C, D, F, and G and Scalaridine A via One-Pot Masuda Borylation-Suzuki Coupling Sequence

Molecules, 2022
N-Protected 3-iodoindoles were reacted with (di)azine halides in a sequentially Pd-catalyzed one-pot fashion, i.e., by Masuda borylation–Suzuki coupling (MBSC) sequence.
Marco Kruppa, Gereon A. Sommer, Thomas J. J. Müller   +2 more
doaj   +1 more source

CrERF5, an AP2/ERF Transcription Factor, Positively Regulates the Biosynthesis of Bisindole Alkaloids and Their Precursors in Catharanthus roseus

Frontiers in Plant Science, 2019
Catharanthus roseus contains a variety of monoterpenoid indole alkaloids (MIAs), among which bisindole alkaloids vinblastine and vincristine are well-known to have antitumor effects and widely used in clinical treatment.
Qifang Pan, Chenyi Wang, Zhiwei Xiong, Hang Wang, Xueqing Fu, Qian Shen, Bowen Peng, Yanan Ma, Xiaofen Sun, Kexuan Tang   +9 more
doaj   +1 more source

Crystal structure of diethyl 3,3′-[(4-nitrophenyl)methylene]bis(1H-indole-2-carboxylate)

Acta Crystallographica Section E: Crystallographic Communications, 2017
In the title compound, C29H25N3O6, the mean planes of the two indole ring systems (r.m.s. deviations = 0.0115 and 0.0082 Å) are approximately perpendicular to one another, making a dihedral angle of 89.7 (5)°; the benzene ring is twisted with respect to ...
Hong-Shun Sun, Yu-Long Li, Hong Jiang, Yu-Liang Chen, Ya-Di Hu   +4 more
doaj   +1 more source

Diethyl 3,3′-[(4-fluorophenyl)methylidene]bis(1H-indole-2-carboxylate)

IUCrData, 2019
In the title compound, C29H25FN2O4, the mean planes of the indole ring systems (r.m.s. deviations = 0.0107 and 0.0158 Å) are approximately perpendicular to each other, subtending a dihedral angle of 87.43 (16)°. The 4-fluorophenyl ring is twisted by 77.6 
Yu-Long Li, Jin Zhou, Kai-Long Zhong, Xing-Hao Shi, Zhi-Yuan Zhang, Hong Jiang, Hong-Shun Sun   +6 more
doaj   +1 more source

Crystal structure of diethyl 3,3′-[(2-fluorophenyl)methylidene]bis(1H-indole-2-carboxylate)

Acta Crystallographica Section E: Crystallographic Communications, 2017
In the title compound, C29H25FN2O4, the mean planes of the two indole ring systems (r.m.s. deviations = 0.1392 and 0.0115 Å) are approximately perpendicular to one another, subtending a dihedral angle of 86.0 (5)°; the benzene ring is twisted with ...
Xin-Hua Lu, Hong-Shun Sun, Yuan Cai, Lu-Lu Chen, Yang-Feng Chen   +4 more
doaj   +1 more source