Results 1 to 10 of about 1,477 (166)

Marine bisindole alkaloid: A potential apoptotic inducer in human cancer cells [PDF]

European Journal of Histochemistry, 2018
Marine organisms such as corals, sponges and tunicates produce active molecules which could represent a valid starting point for new drug development processes.
Sara Salucci, Sabrina Burattini, Francesca Buontempo, Ester Orsini, Lucia Furiassi, Michele Mari, Simone Lucarini, Alberto M. Martelli, Elisabetta Falcieri   +8 more
doaj   +5 more sources

Marine Alkaloid 2,2-Bis(6-bromo-3-indolyl) Ethylamine and Its Synthetic Derivatives Inhibit Microbial Biofilms Formation and Disaggregate Developed Biofilms [PDF]

Microorganisms, 2019
The antimicrobial activity of the marine bisindole alkaloid 2,2-bis(6-bromo-3-indolyl) ethylamine (1) and related synthetic analogues (compounds 2⁻8) against target microorganisms was investigated by Minimum Inhibitory Concentration (MIC ...
Raffaella Campana, Gianfranco Favi, Wally Baffone, Simone Lucarini   +3 more
doaj   +3 more sources

A Fluorinated Analogue of Marine Bisindole Alkaloid 2,2-Bis(6-bromo-1H-indol-3-yl)ethanamine as Potential Anti-Biofilm Agent and Antibiotic Adjuvant Against Staphylococcus aureus [PDF]

Pharmaceuticals, 2020
Methicillin resistant Staphylococcus aureus (MRSA) infections represent a major global healthcare problem. Therapeutic options are often limited by the ability of MRSA strains to grow as biofilms on medical devices, where antibiotic persistence and ...
Raffaella Campana, Gianmarco Mangiaterra, Mattia Tiboni, Emanuela Frangipani, Francesca Biavasco, Simone Lucarini, Barbara Citterio   +6 more
doaj   +2 more sources

The Bisindole Alkaloid Caulerpin, from Seaweeds of the Genus Caulerpa, Attenuated Colon Damage in Murine Colitis Model [PDF]

Marine Drugs, 2018
Caulerpin (CLP), an alkaloid from algae of the genus Caulerpa, has shown anti-inflammatory activity. Therefore, this study aimed to analyze the effect of CLP in the murine model of peritonitis and ulcerative colitis.
Alessandra M. M. Lucena, Cássio R. M. Souza, Jéssica T. Jales, Paulo M. M. Guedes, George E. C. de Miranda, Adolpho M. A. de Moura, João X. Araújo-Júnior, George J. Nascimento, Kátia C. Scortecci, Barbara V. O. Santos, Janeusa T. Souto   +10 more
doaj   +2 more sources

The Antinociceptive and Anti-Inflammatory Activities of Caulerpin, a Bisindole Alkaloid Isolated from Seaweeds of the Genus Caulerpa [PDF]

Marine Drugs, 2009
The antinociceptive and anti-inflammatory activity of caulerpin was investigated. This bisindole alkaloid was isolated from the lipoid extract of Caulerpa racemosa and its structure was identified by spectroscopic methods, including IR and NMR techniques.
Magna Suzana Alexandre-Moreira, Bárbara Viviana de Oliveira Santos, Petrônio Filgueiras de Athayde-Filho, José Maria Barbosa-Filho, João Xavier de Araújo-Júnior, Maria Célia de Oliveira Chaves, George Emmanuel C. de Miranda, Vitor Prates Lorenzo, Eliane A. Campessato Mella, Anansa Bezerra de Aquino, Diogo José Costa da Silva, Daysianne Pereira de Lira, Aline Cavalcanti de Queiroz, Éverton Tenório de Souza   +13 more
doaj   +2 more sources

Cytotoxic Activity, and Molecular Docking of Indole Alkaloid Voacangine and Bisindole Alkaloid Vobtusine, Vobtusine Lactone from the Indonesian Plant: Voacanga foetida (Blume) Rolfe [PDF]

Journal of Natural Products, 2021
The purpose of this study was to isolate and test its cytotoxic activity starting from extract fraction and its isolate compound, then carried out molecular docking to confirm the potential biological activity of ligands (vocangine, vobtusine, and ...
Amelia, Puteri, Dachriyanus, Dachriyanus, Frengki, Frengki, Hirasawa, Yusuke, Ikhtiarudin, Ihsan, Kaneda, Toshio, Morita, Hiroshi, Susanty, Adriani, Wahyuni, Fatma Sri, Yanwirasti, Yanwirasti   +9 more
core   +5 more sources

Brominated Bisindole Alkaloids from the Celtic Sea Sponge Spongosorites calcicola [PDF]

Molecules, 2019
As part of an ongoing program to identify new bioactive compounds from Irish marine bioresources, we selected the subtidal sponge Spongosorites calcicola for chemical study, as fractions of this species displayed interesting cytotoxic bioactivities and ...
Laurence K. Jennings, Neyaz M. D. Khan, Navdeep Kaur, Daniel Rodrigues, Christine Morrow, Aoife Boyd, Olivier P. Thomas   +6 more
doaj   +3 more sources

1H NMR Spectroscopy and MVA Analysis of Diplodus sargus Eating the Exotic Pest Caulerpa cylindracea [PDF]

Marine Drugs, 2015
The green alga Caulerpa cylindracea is a non-autochthonous and invasive species that is severely affecting the native communities in the Mediterranean Sea. Recent researches show that the native edible fish Diplodus sargus actively feeds on this alga and
Sandra A. De Pascali, Laura Del Coco, Serena Felline, Ernesto Mollo, Antonio Terlizzi, Francesco P. Fanizzi   +5 more
doaj   +4 more sources

Efficient and Rapid Arylation of NH₂-Unprotected Bromobisindole Ethanamines via Suzuki-Miyaura Coupling: Generating New Leads Against Leishmania. [PDF]

Chemistry
Leishmaniasis is a neglected tropical disease which presents significant global health challenges due to the lack of effective vaccines and the limitations of existing chemotherapeutics in view of their toxicity, resistance, and high costs. In this study,
Buono A, Diotallevi A, Maestrini S, Verboni M, Kiuru P, Galluzzi L, Duranti A, Olivieri D, Lucarini S.   +8 more
europepmc   +3 more sources

Exploring of therapeutic potential of indirubin-loaded nanofibrous scaffolds for localized melanoma treatment [PDF]

Journal of Biological Engineering
Nanofibrous scaffolds have been established as capable platforms for localized drug delivery systems of skin cancer management. Our study aimed to develop an electrospun nanofibrous scaffold loaded with indirubin, a naturally occurring bisindole alkaloid
Sajad Rahimi, Kamyar Khoshnevisan, Amir Hossein Izadi Nazar, Maryam Doostan, Hassan Maleki   +4 more
doaj   +2 more sources