Results 11 to 20 of about 971 (184)

Marine bisindole alkaloid: A potential apoptotic inducer in human cancer cells [PDF]

European Journal of Histochemistry, 2018
Marine organisms such as corals, sponges and tunicates produce active molecules which could represent a valid starting point for new drug development processes.
Sara Salucci, Sabrina Burattini, Francesca Buontempo, Ester Orsini, Lucia Furiassi, Michele Mari, Simone Lucarini, Alberto M. Martelli, Elisabetta Falcieri   +8 more
doaj   +7 more sources

A Fluorinated Analogue of Marine Bisindole Alkaloid 2,2-Bis(6-bromo-1H-indol-3-yl)ethanamine as Potential Anti-Biofilm Agent and Antibiotic Adjuvant Against Staphylococcus aureus [PDF]

Pharmaceuticals, 2020
Methicillin resistant Staphylococcus aureus (MRSA) infections represent a major global healthcare problem. Therapeutic options are often limited by the ability of MRSA strains to grow as biofilms on medical devices, where antibiotic persistence and ...
Raffaella Campana, Gianmarco Mangiaterra, Mattia Tiboni, Emanuela Frangipani, Francesca Biavasco, Simone Lucarini, Barbara Citterio   +6 more
doaj   +2 more sources

The Bisindole Alkaloid Caulerpin, from Seaweeds of the Genus Caulerpa, Attenuated Colon Damage in Murine Colitis Model [PDF]

Marine Drugs, 2018
Caulerpin (CLP), an alkaloid from algae of the genus Caulerpa, has shown anti-inflammatory activity. Therefore, this study aimed to analyze the effect of CLP in the murine model of peritonitis and ulcerative colitis.
Alessandra M. M. Lucena, Cássio R. M. Souza, Jéssica T. Jales, Paulo M. M. Guedes, George E. C. de Miranda, Adolpho M. A. de Moura, João X. Araújo-Júnior, George J. Nascimento, Kátia C. Scortecci, Barbara V. O. Santos, Janeusa T. Souto   +10 more
doaj   +2 more sources

Synthesis of Bisindole Alkaloids from the Apocynaceae Which Contain a Macroline or Sarpagine Unit: A Review

Molecules, 2016
Bisindole natural products consist of two monomeric indole alkaloid units as their obligate constituents. Bisindoles are more potent with respect to their biological activity than their corresponding monomeric units.
Md Toufiqur Rahman, Veera V. N. Phani Babu Tiruveedhula, James M. Cook   +2 more
doaj   +3 more sources

The Antinociceptive and Anti-Inflammatory Activities of Caulerpin, a Bisindole Alkaloid Isolated from Seaweeds of the Genus Caulerpa [PDF]

Marine Drugs, 2009
The antinociceptive and anti-inflammatory activity of caulerpin was investigated. This bisindole alkaloid was isolated from the lipoid extract of Caulerpa racemosa and its structure was identified by spectroscopic methods, including IR and NMR techniques.
Magna Suzana Alexandre-Moreira, Bárbara Viviana de Oliveira Santos, Petrônio Filgueiras de Athayde-Filho, José Maria Barbosa-Filho, João Xavier de Araújo-Júnior, Maria Célia de Oliveira Chaves, George Emmanuel C. de Miranda, Vitor Prates Lorenzo, Eliane A. Campessato Mella, Anansa Bezerra de Aquino, Diogo José Costa da Silva, Daysianne Pereira de Lira, Aline Cavalcanti de Queiroz, Éverton Tenório de Souza   +13 more
doaj   +2 more sources

The Chemistry of Grandifoline, a Bisindole Alkaloid

, 1979
Department of Pure Chemistry, University College of Science, 92, Acharya P. C.
(Mrs.) A. CHATTERJEE
openaire   +3 more sources

Biscarpamontamines A and B, an Aspidosperma−Iboga Bisindole Alkaloid and an Aspidosperma−Aspidosperma Bisindole Alkaloid, from Tabernaemontana sphaerocarpa [PDF]

Journal of Natural Products, 2009
Two new bisindole alkaloids, biscarpamontamine A (1), possessing an aspidosperma-iboga-type skeleton, and biscarpamontamine B (2), having an aspidosperma-aspidosperma-type skeleton, were isolated from stems of Tabernaemontana sphaerocarpa, and their structures were elucidated on the basis of spectroscopic data analysis.
Kazumasa Zaima, -, Tomoko Hirata, -, Takahiro Hosoya, -, Yusuke Hirasawa, -, Koichiro Koyama, -, Abdul Rahman, -, Idha Kusumawati, -, Noor Cholies Zaini, -, Motoo Shiro, -, Hiroshi Morita, -   +9 more
openaire   +4 more sources

Exploring of therapeutic potential of indirubin-loaded nanofibrous scaffolds for localized melanoma treatment [PDF]

Journal of Biological Engineering
Nanofibrous scaffolds have been established as capable platforms for localized drug delivery systems of skin cancer management. Our study aimed to develop an electrospun nanofibrous scaffold loaded with indirubin, a naturally occurring bisindole alkaloid
Sajad Rahimi, Kamyar Khoshnevisan, Amir Hossein Izadi Nazar, Maryam Doostan, Hassan Maleki   +4 more
doaj   +2 more sources

Exploration of the effect and mechanism of indirubin on infectious bovine rhinotracheitis virus based on network pharmacology [PDF]

BMC Veterinary Research
Background Our team’s previous research indicates that infectious bovine rhinotracheitis virus (IBRV) induces mitochondrial damage in bovine kidney cells (MDBK). Indirubin, a bisindole alkaloid, can alleviate mitochondrial damage.
Xuelian Ma, Heqi Lv, Xinbo Liu, Yingcai Ma, Qian Jiang, Jingqing Lv, Xin Li, Na Li, Qi Zhong, Gang Yao   +9 more
doaj   +2 more sources

Conofolidine: A Natural Plant Alkaloid That Causes Apoptosis and Senescence in Cancer Cells [PDF]

Molecules
Natural products contribute substantially to anticancer therapy; the plant kingdom provides an important source of molecules. Conofolidine is a novel Aspidosperma-Aspidosperma bisindole alkaloid isolated from the Malayan plant Tabernaemontana corymbosa ...
Mohammed Zuhair Al-Hayali, Choy-Eng Nge, Kuan Hon Lim, Hilary M. Collins, Toh-Seok Kam, Tracey D. Bradshaw   +5 more
doaj   +2 more sources