Results 21 to 30 of about 755 (153)
Enantioselective Strategies for The Synthesis of N−N Atropisomers
Angewandte Chemie, Volume 135, Issue 31, August 1, 2023., 2023 Recent advances in the enantioselective synthesis of N−N atropisomers are highlighted and discussed within this Review. In particular, the strategies and breakthroughs to obtain this novel and stimulating atropisomeric architecture are presented while a particular attention is given to mechanistic aspects.
Giovanni Centonze +3 more
wiley +1 more source
Assessment of Mechanisms Involved in Antinociception Produced by the Alkaloid Caulerpine
Molecules, 2014 In previous works we showed that oral administration of caulerpine, a bisindole alkaloid isolated from algae of the genus Caulerpa, produced antinociception when assessed in chemical and thermal models of nociception.
Luiz Henrique Agra Cavalcante-Silva +11 more
doaj +1 more source
Attempted Synthesis of Vinca Alkaloids Condensed with Three-Membered Rings
Molecules, 2018 Our successful work for the synthesis of cyclopropanated vinblastine and its derivatives by the Simmons–Smith reaction was followed to build up further three-membered rings into the 14,15-position of the vindoline part of the dimer alkaloid ...
András Keglevich +8 more
doaj +1 more source
Molecules, 2007 Dried leaves of Catharanthus roseus were extracted with aqueous acidic 0.1 M solution of HCl. Alkaloid-embonate complexes were obtained as precipitates by treating the extract with an alkaline (NaOH) solution of embonic acid (4,4-methylene-bis-3 ...
Marja-Liisa Riekkola +4 more
doaj +1 more source
A Facile Synthesis of Deaza-Analogues of the Bisindole Marine Alkaloid Topsentin
Molecules, 2013 A series of substituted ethyl 1-[(tert-butoxycarbonyl)amino]-2-methyl-5- (1-methyl-1H-indol-3-yl)-4-[(1-methyl-1H-indol-3-yl)carbonyl]-1H-pyrrole-3-carboxylates were prepared in excellent yields (82-98%) by one-pot reactions between β-dicarbonyl ...
Gianfranco Favi +5 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Non-small cell lung cancer (NSCLC) is one of the most common malignancies in the world. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have been used as a first-line treatment for patients harboring with EGFR mutations in ...
Shike Yan +12 more
doaj +1 more source
Transcriptome analysis of Catharanthus roseus for gene discovery and expression profiling. [PDF]
PLoS ONE, 2014 The medicinal plant, Catharanthus roseus, accumulates wide range of terpenoid indole alkaloids, which are well documented therapeutic agents. In this study, deep transcriptome sequencing of C.
Mohit Verma +4 more
doaj +1 more source
Two new bisindole alkaloids from Tabernaemontana macrocarpa Jack [PDF]
Journal of Natural Medicines, 2021 Two new bisindole alkaloids, bisnaecarpamines A (1) and B (2), possessing a vobasine-sarpagine type skeleton were isolated from the bark of Tabernaemontana macrocarpa Jack. Their structures were elucidated by extensive spectroscopic methods and chemical correlation.
Amelia, Puteri +6 more
openaire +2 more sources
Spasmolytic Effect of Caulerpine Involves Blockade of Ca2+ Influx on Guinea Pig Ileum
Marine Drugs, 2013 In this work, we investigated the spasmolytic effect of caulerpine, a bisindole alkaloid isolated from marine algae of the Caulerpa genus, on guinea pig ileum.
Magna Suzana Alexandre-Moreira +9 more
doaj +1 more source
Brominated Bisindole Alkaloids from the Celtic Sea Sponge Spongosorites calcicola
Molecules, 2019 As part of an ongoing program to identify new bioactive compounds from Irish marine bioresources, we selected the subtidal sponge Spongosorites calcicola for chemical study, as fractions of this species displayed interesting cytotoxic bioactivities and ...
Laurence K. Jennings +6 more
doaj +1 more source