Results 21 to 30 of about 971 (184)

Efficient and Rapid Arylation of NH₂-Unprotected Bromobisindole Ethanamines via Suzuki-Miyaura Coupling: Generating New Leads Against Leishmania. [PDF]

Chemistry
A library of novel bisindole derivatives was synthesized through an optimized rapid Suzuki‐Miyaura coupling reaction, utilizing NH2‐unprotected bromobisindole ethanamines and boronic acids with yields up to 93%. The compounds were screened for their activity against L. infantum promastigotes.
Buono A, Diotallevi A, Maestrini S, Verboni M, Kiuru P, Galluzzi L, Duranti A, Olivieri D, Lucarini S.   +8 more
europepmc   +2 more sources

Combined Transcriptomic and Metabolomic Analysis Reveals an Ethylene-Activated Regulatory Model on Monoterpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus. [PDF]

Plant Biotechnol J
ABSTRACT Catharanthus roseus contains nearly 200 bioactive monoterpenoid indole alkaloids (MIAs) that are effective in treating cancer and other diseases. Ethylene plays a significant role in enhancing MIA biosynthesis, and we have found that it greatly induces the accumulation of anhydrovinblastine.
Deng B, Miao Q, Ou C, Pan Y, Liu H, Fu X, Li L, Wang Y, Tang K, Pan Q.   +9 more
europepmc   +2 more sources

Concise Syntheses of Marine (Bis)indole Alkaloids Meridianin C, D, F, and G and Scalaridine A via One-Pot Masuda Borylation-Suzuki Coupling Sequence

Molecules, 2022
N-Protected 3-iodoindoles were reacted with (di)azine halides in a sequentially Pd-catalyzed one-pot fashion, i.e., by Masuda borylation–Suzuki coupling (MBSC) sequence.
Marco Kruppa, Gereon A. Sommer, Thomas J. J. Müller   +2 more
doaj   +1 more source

One-Pot Synthesis of Novel β-Carboline-{α-Acylaminoamide}-Bisindole Derivatives: Antibacterial Evaluation, Molecular Docking, and Density Functional Theory Studies. [PDF]

ChemistryOpen
A new series of β‐carboline‐{α‐acylaminoamide}‐bisindole hybrids (12a–l) employing an atom‐economical one‐pot Ugi four‐component reaction and their antibacterial testing alongside docking studies, is reported. A new series of β‐carboline‐{α‐acylaminoamide}‐bisindole hybrids (12a–l) is designed and synthesized employing an atom‐economical one‐pot Ugi ...
Atri AK, Khullar L, Kumar G, Mishra S, Dua T, Singh V, Harjai K, Singh P, Singh V.   +8 more
europepmc   +2 more sources

Discovery of Barakacin and Its Derivatives as Novel Antiviral and Fungicidal Agents

Molecules, 2023
Pesticides are essential for the development of agriculture. It is urgent to develop green, safe and efficient pesticides. Bisindole alkaloids have unique and concise structures and broad biological activities, which make them an important leading ...
Yongyue Gao, Xingxing He, Lili Yan, Hongyu Zhang, Sijia Liu, Qian Ma, Peiyao Zhang, Yan Zhang, Zijun Zhang, Ziwen Wang, Aidang Lu, Qingmin Wang   +11 more
doaj   +1 more source

Oxidative Rearrangements of the Alkaloid Intermediate Geissoschizine. [PDF]

Angew Chem Int Ed Engl
19E‐geissoschizine is a key precursor in the biosynthesis of monoterpene indole alkaloids such as strychnine, ibogaine, and vinblastine. Using enzymatic assays and gene silencing, three CYPs were identified from C. roseus that oxidize this compound to four alkaloid scaffolds: strychnos, sarpagan, akuammiline, and mavacurane. Mutational analysis reveals
Kamileen MO, Hong B, Gase K, Kunert M, Caputi L, Lichman BR, O'Connor SE.   +6 more
europepmc   +3 more sources

An Alkaloid from a Highly Invasive Seaweed Increases the Voracity and Reproductive Output of a Model Fish Species

Marine Drugs, 2022
The invasive macroalga Caulerpa cylindracea has spread widely in the Mediterranean Sea, becoming a favorite food item for native fish for reasons yet unknown.
Valentina Schiano, Adele Cutignano, Daniela Maiello, Marianna Carbone, Maria Letizia Ciavatta, Gianluca Polese, Federica Fioretto, Chiara Attanasio, Antonio Palladino, Serena Felline, Antonio Terlizzi, Livia D’Angelo, Paolo de Girolamo, Mimmo Turano, Carla Lucini, Ernesto Mollo   +15 more
doaj   +1 more source

Eight Indole Alkaloids from the Roots of Maerua siamensis and Their Nitric Oxide Inhibitory Effects

Molecules, 2022
Maerua siamensis (Capparaceae) roots are used for treating pain and inflammation in traditional Thai medicine. Eight new indole alkaloids, named maeruanitriles A and B, maeroximes A–C, and maeruabisindoles A–C, were isolated from them.
Sasiwimon Nukulkit, Angkana Jantimaporn, Preeyaporn Poldorn, Mattaka Khongkow, Thanyada Rungrotmongkol, Hsun-Shuo Chang, Rutt Suttisri, Chaisak Chansriniyom   +7 more
doaj   +1 more source

Bisindole alkaloids from Voacanga grandifolia leaves

Journal of Natural Medicines, 2021
Two new bisindole alkaloids, 12'-O-demethyl-vobtusine-5-lactam and isovobtusine-N-oxide (1 and 2), were isolated from the leaves of Voacanga grandifolia, together with two known bisindole alkaloids. Their structures were elucidated on the basis of 1D and 2D NMR data. 1 and 2 showed potent antimalarial activity against Plasmodium falciparum 3D7 and very
Alfarius Eko Nugroho, -, Yurika Ono, -, Eunji Jin, -, Yusuke Hirasawa, -, Toshio Kaneda, -, Abdul Rahman, -, Idha Kusumawati, -, Takahiro Tougan, -, Toshihiro Horii, -, Noor Cholies Zaini, -, Hiroshi Morita, -   +10 more
openaire   +3 more sources

Morpho‐functional analyses reveal that changes in the chemical structure of a marine bisindole alkaloid alter the cytotoxic effect of its derivatives [PDF]

, 2022
2,2-bis(6-bromo-1H-indol-3-yl) ethanamine, a marine bisindole alkaloid, showed anticancer property in several tumor cell lines thanks to the presence of a 3,30- diindolylmethane scaffold. Here, the modifications in its chemical structure into alkaloid-
Irene Faenza, Battistelli, Michela, Michele Verboni, Simone Lucarini, Burattini, Sabrina, Salucci, Sara, Elisabetta Falcieri, Sara Salucci, Sabrina Burattini, Faenza, Irene, Falcieri, Elisabetta, Lucarini, Simone, Michela Battistelli, Verboni, Michele   +13 more
core   +1 more source