Enantioselective Strategies for The Synthesis of N−N Atropisomers
Angewandte Chemie, Volume 135, Issue 31, August 1, 2023., 2023 Recent advances in the enantioselective synthesis of N−N atropisomers are highlighted and discussed within this Review. In particular, the strategies and breakthroughs to obtain this novel and stimulating atropisomeric architecture are presented while a particular attention is given to mechanistic aspects.
Giovanni Centonze +3 more
wiley +2 more sources
Eight Indole Alkaloids from the Roots of Maerua siamensis and Their Nitric Oxide Inhibitory Effects
Molecules, 2022 Maerua siamensis (Capparaceae) roots are used for treating pain and inflammation in traditional Thai medicine. Eight new indole alkaloids, named maeruanitriles A and B, maeroximes A–C, and maeruabisindoles A–C, were isolated from them.
Sasiwimon Nukulkit +7 more
doaj +1 more source
Cloning and Overexpression of Strictosidine β-D-Glucosidase Gene Short Sequence from Catharanthus roseus in Escherichia coli [PDF]
Advanced Pharmaceutical Bulletin, 2019 Purpose: Strictosidine-β-D-glucosidase (SGD) is considered as a key enzyme in the production of bisindole alkaloids in Catharanthus roseus. The present study illustrated the production of a short sequence of this enzyme in Escherichia coli without codon ...
Ahmed Saeed Arafa +4 more
doaj +1 more source
Ligand-Based Pharmacophore Mapping and Virtual Screening for the Search of Biguanide-Like Molecules With Antidiabetic Potentials Targeting Liver Kinase B1. [PDF]
Biochem Res IntType 2 diabetes mellitus (T2DM) is a state where the body’s glucose metabolism is compromised. AMP‐activated protein kinase, or AMPK, has an important part to play in glucose metabolism, and the liver kinase B1 (LKB1) protein functions as a major upstream kinase for AMPK activation, thereby making it appealing therapeutic targets for treating and ...
Reza R +5 more
europepmc +2 more sources
Molecules, 2016 Bisindole natural products consist of two monomeric indole alkaloid units as their obligate constituents. Bisindoles are more potent with respect to their biological activity than their corresponding monomeric units.
Md Toufiqur Rahman +2 more
doaj +1 more source
Alkaloids from marine ascidians [PDF]
, 2011 About 300 alkaloid structures isolated from marine ascidians are discussed in term of their occurrence, structural type and reported pharmacol. activity.
FATTORUSSO, ERNESTO +2 more
core +3 more sources
Biotransformation Of l‐Tryptophan To Produce Arcyriaflavin A With Pseudomonas putida KT2440
ChemBioChem, Volume 24, Issue 23, December 1, 2023., 2023 Arcyriaflavin A was produced in Pseudomonas putida KT2440 using genes from Lentzea aerocolonigenes. Cultivation conditions and supply of the precursor l‐tryptophan were optimized. Genetic engineering of outer membrane vesicle release and cultivation with polyurethane adsorbent resulted in product enrichment in the supernatant.
Nora Lisa Bitzenhofer +3 more
wiley +1 more source
3-[4-(1H-indol-3-yl)-1,3-thiazol-2-yl]-1H-pyrrolo[2,3-b]pyridines, nortopsentin Analogues with antiproliferative activity [PDF]
, 2015 A new series of nortopsentin analogues, in which the imidazole ring of the natural product was replaced by thiazole and the indole unit bound to position 2 of the thiazole ring was substituted by a 7-azaindole moiety, was efficiently synthesized.
Attanzio, A. +11 more
core +2 more sources
Facilitating biomimetic syntheses of borrerine derived alkaloids by means of flow-chemical methods [PDF]
, 2015 Flow chemistry is widely used nowadays in synthetic chemistry and has increasingly been applied to complex natural product synthesis. However, to date flow chemistry has not found a place in the area of biomimetic synthesis.
Kamptmann, SB, Ley, SV
core +1 more source
Assessment of Mechanisms Involved in Antinociception Produced by the Alkaloid Caulerpine
Molecules, 2014 In previous works we showed that oral administration of caulerpine, a bisindole alkaloid isolated from algae of the genus Caulerpa, produced antinociception when assessed in chemical and thermal models of nociception.
Luiz Henrique Agra Cavalcante-Silva +11 more
doaj +1 more source