Results 31 to 40 of about 48,569 (170)

FGFC1 Selectively Inhibits Erlotinib-Resistant Non-Small Cell Lung Cancer via Elevation of ROS Mediated by the EGFR/PI3K/Akt/mTOR Pathway

Frontiers in Pharmacology, 2022
Non-small cell lung cancer (NSCLC) is one of the most common malignancies in the world. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have been used as a first-line treatment for patients harboring with EGFR mutations in ...
Shike Yan, Bing Zhang, Jingwen Feng, Haigang Wu, Namin Duan, Yamin Zhu, Yueliang Zhao, Shuang Shen, Kai Zhang, Wenhui Wu, Wenhui Wu, Ning Liu, Ning Liu   +12 more
doaj   +1 more source

Two new bisindole alkaloids from Tabernaemontana macrocarpa Jack [PDF]

Journal of Natural Medicines, 2021
Two new bisindole alkaloids, bisnaecarpamines A (1) and B (2), possessing a vobasine-sarpagine type skeleton were isolated from the bark of Tabernaemontana macrocarpa Jack. Their structures were elucidated by extensive spectroscopic methods and chemical correlation.
Amelia, Puteri, Nugroho, Alfarius Eko, Hirasawa, Yusuke, Kaneda, Toshio, Tougan, Takahiro, Horii, Toshihiro, Morita, Hiroshi   +6 more
openaire   +2 more sources

Transcriptome analysis of Catharanthus roseus for gene discovery and expression profiling. [PDF]

PLoS ONE, 2014
The medicinal plant, Catharanthus roseus, accumulates wide range of terpenoid indole alkaloids, which are well documented therapeutic agents. In this study, deep transcriptome sequencing of C.
Mohit Verma, Rajesh Ghangal, Raghvendra Sharma, Alok K Sinha, Mukesh Jain   +4 more
doaj   +1 more source

Spasmolytic Effect of Caulerpine Involves Blockade of Ca2+ Influx on Guinea Pig Ileum

Marine Drugs, 2013
In this work, we investigated the spasmolytic effect of caulerpine, a bisindole alkaloid isolated from marine algae of the Caulerpa genus, on guinea pig ileum.
Magna Suzana Alexandre-Moreira, George Emmanuel C. de Miranda, Fabiana de Andrade Cavalcante, Jéssica Celestino Ferreira Sousa, Daysianne Pereira de Lira, Bárbara Viviana de Oliveira Santos, Bagnólia Araújo da Silva, Ana Carolina de Carvalho Correia, José Maria Barbosa-Filho, Luiz Henrique Agra Cavalcante-Silva   +9 more
doaj   +1 more source

Leucophyllidine, a Cytotoxic Bisindole Alkaloid Constituted From the Union of an Eburnan and a New Vinylquinoline Alkaloid

, 2016
A cytotoxic bisindole alkaloid possessing an unprecedented structure constituted from the union of an eburnan half and a novel vinylquinoline alkaloid has been isolated from Leuconotis griffithii.
Tadahiro Etoh (2196640), Masahiko Hayashi (1320954), Chew-Yan Gan (1426528), Ward T. Robinson (2324653), Kanki Komiyama (2196643), Toh-Seok Kam (1426537)   +5 more
core   +2 more sources

10'-Hydroxyusambarensine, a New Antimalarial Bisindole Alkaloid from the Roots of Strychnos Usambarensis [PDF]

, 1999
peer reviewedReinvestigation of Strychnos usambarensis Gilg resulted in the isolation of a tertiary phenolic bisindole alkaloid, 10'-hydroxyusambarensine (1), which was identified by detailed spectroscopic methods.
Angenot, Luc, Frederich, Michel, Hayette, Marie-Pierre, De Mol, Patrick, Tits, Monique, Brandt, Viviane, Llabres, Gabriel, Penelle, Jacques   +7 more
core   +1 more source

Guiaflavine, a New Bisindole Quaternary Alkaloid from the Stem Bark of Strychnos Guianensis [PDF]

, 1999
peer reviewedA reinvestigation of Strychnos guianensis resulted in the isolation of a colored quaternary bisindole alkaloid from the stem bark. The structure of this new substance, guiaflavine (1), was defined by detailed spectroscopic methods and ...
Angenot, Luc, Penelle, J., Frederich, Michel, Christen, Philippe, Tits, Monique, Christen, P., Brandt, V., Penelle, Jacques   +7 more
core   +1 more source

Strychnochrysine, a New Bisindole Alkaloid from the Roots of Strychnos Nux-Vomica [PDF]

, 1998
peer reviewedThe reinvestigation of Strychnos nux-vomica resulted in the isolation of a colored monoquaternary bisindole alkaloid from the roots. The structure of this new orange substance, strychnochrysine (1), was defined by detailed spectroscopic ...
Angenot, Luc, Biala, Rose Gadi, Frederich, Michel, Tits, Monique, Brandt, Viviane, Llabres, Gabriel, Penelle, Jacques, Prosperi, Christelle   +7 more
core   +1 more source

Brominated Bisindole Alkaloids from the Celtic Sea Sponge Spongosorites calcicola

Molecules, 2019
As part of an ongoing program to identify new bioactive compounds from Irish marine bioresources, we selected the subtidal sponge Spongosorites calcicola for chemical study, as fractions of this species displayed interesting cytotoxic bioactivities and ...
Laurence K. Jennings, Neyaz M. D. Khan, Navdeep Kaur, Daniel Rodrigues, Christine Morrow, Aoife Boyd, Olivier P. Thomas   +6 more
doaj   +1 more source

Voacinol: a new bisindole alkaloid from Voacanga grandifolia (Miq) rolfe

, 1987
Voacinol, a new bisindole alkaloid from Voacanga grandifolia has been assigned a 14,14'-methylene-bis-18-hydroxytabersonine structure (1), on the basis of spectral ...
Govindachari, Tuticorin R., Sandhya, Gopalan, Chandrasekharan, Sundaram, Rajagopalan, Krishnamoorthy   +3 more
core   +1 more source