Results 31 to 40 of about 755 (153)

From Racemic to Enantioselective Total Synthesis of Trigonoliimines via Development of an Organocatalytic Enantioselective Michael Addition of ?-Aryl-?-isocyanoacetate to Vinyl Phenyl Selenone

CHIMIA, 2014
Trigonoliimines are hexacyclic bisindole alkaloids isolated recently by Hao and co-workers. A synthesis of (±)-trigonoliimine B was accomplished in seven steps from simple starting materials featuring the Bischler-Napieralski reaction for ...
Thomas Buyck, Qian Wang, Jieping Zhu
doaj   +1 more source

Dragmacidin G, a Bioactive Bis-Indole Alkaloid from a Deep-Water Sponge of the Genus Spongosorites

Marine Drugs, 2017
A deep-water sponge of the genus Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G was first reported by us in the patent literature and has recently been reported by Hitora et al. from a sponge of the genus
Amy E. Wright, K. Brian Killday, Debopam Chakrabarti, Esther A. Guzmán, Dedra Harmody, Peter J. McCarthy, Tara Pitts, Shirley A. Pomponi, John K. Reed, Bracken F. Roberts, Carolina Rodrigues Felix, Kyle H. Rohde   +11 more
doaj   +1 more source

Biscarpamontamines A and B, an Aspidosperma−Iboga Bisindole Alkaloid and an Aspidosperma−Aspidosperma Bisindole Alkaloid, from Tabernaemontana sphaerocarpa

Journal of Natural Products, 2009
Two new bisindole alkaloids, biscarpamontamine A (1), possessing an aspidosperma-iboga-type skeleton, and biscarpamontamine B (2), having an aspidosperma-aspidosperma-type skeleton, were isolated from stems of Tabernaemontana sphaerocarpa, and their structures were elucidated on the basis of spectroscopic data analysis.
Kazumasa Zaima, -, Tomoko Hirata, -, Takahiro Hosoya, -, Yusuke Hirasawa, -, Koichiro Koyama, -, Abdul Rahman, -, Idha Kusumawati, -, Noor Cholies Zaini, -, Motoo Shiro, -, Hiroshi Morita, -   +9 more
openaire   +3 more sources

Synthesis of Pseudellone Analogs and Characterization as Novel T-type Calcium Channel Blockers

Marine Drugs, 2018
T-type calcium channel (CaV3.x) blockers are receiving increasing attention as potential therapeutics for the treatment of pathophysiological disorders and diseases, including absence epilepsy, Parkinson’s disease (PD), hypertension, cardiovascular
Dan Wang, Pratik Neupane, Lotten Ragnarsson, Robert J. Capon, Richard J. Lewis   +4 more
doaj   +1 more source

Alkaloids with Anti-Onchocercal Activity from Voacanga africana Stapf (Apocynaceae): Identification and Molecular Modeling

Molecules, 2020
A new iboga-vobasine-type isomeric bisindole alkaloid named voacamine A (1), along with eight known compounds—voacangine (2), voacristine (3), coronaridine (4), tabernanthine (5), iboxygaine (6), voacamine (7), voacorine (8) and conoduramine (9)—were ...
Smith B. Babiaka, Conrad V. Simoben, Kennedy O. Abuga, James A. Mbah, Rajshekhar Karpoormath, Dennis Ongarora, Hannington Mugo, Elvis Monya, Fidelis Cho-Ngwa, Wolfgang Sippl, Edric Joel Loveridge, Fidele Ntie-Kang   +11 more
doaj   +1 more source

Emerging Roles of Adenosine Metabolism in Astrocytes During Brain Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
Adenosine, as a key metabolic and neurotransmitter in the brain, has become an important therapeutic target for improving the efficacy of immunotherapy for stroke. However, gaps in knowledge about its metabolic pathways have become a key factor limiting its clinical translation.
Shu Zhu, Shanshan Zhong, Xiaoru Lin, Chuansheng Zhao, Yugang Li   +4 more
wiley   +1 more source

Photoprotective Activity of Topsentin, A Bis(Indole) Alkaloid from the Marine Sponge Spongosorites genitrix, by Regulation of COX-2 and Mir-4485 Expression in UVB-Irradiated Human Keratinocyte Cells

Marine Drugs, 2020
Skin is an important barrier to protect the body from environmental stress. However, exposure to ultraviolet radiation (UV) and various environmental oxidative stresses can cause skin inflammation.
Jiyoung Hwang, Donghwa Kim, Jae Sung Park, Hyen Joo Park, Jongheon Shin, Sang Kook Lee   +5 more
doaj   +1 more source

2,3‐Dichloro‐5,6‐Dicyano‐1,4‐Benzoquinone (DDQ)‐Mediated CC Bond Formation: Redox Strategies from Stoichiometric to Catalytic Systems

ChemistryOpen, Volume 15, Issue 4, April 2026.
2,3‐Dichloro‐5,6‐dicyano‐1,4‐benzoquinone serves as a versatile oxidant and redox catalyst for CC bond formation through hydride abstraction or single‐electron transfer. Stoichiometric and catalytic systems enable benzylic, allylic, and aromatic CH activation under mild, metal‐free conditions, providing sustainable routes to complex and bioactive ...
Dohoon Cha, Sun‐Joon Min
wiley   +1 more source

1H NMR Spectroscopy and MVA Analysis of Diplodus sargus Eating the Exotic Pest Caulerpa cylindracea

Marine Drugs, 2015
The green alga Caulerpa cylindracea is a non-autochthonous and invasive species that is severely affecting the native communities in the Mediterranean Sea. Recent researches show that the native edible fish Diplodus sargus actively feeds on this alga and
Sandra A. De Pascali, Laura Del Coco, Serena Felline, Ernesto Mollo, Antonio Terlizzi, Francesco P. Fanizzi   +5 more
doaj   +1 more source

Ligand‐Based Pharmacophore Mapping and Virtual Screening for the Search of Biguanide‐Like Molecules With Antidiabetic Potentials Targeting Liver Kinase B1

Biochemistry Research International, Volume 2026, Issue 1, 2026.
Type 2 diabetes mellitus (T2DM) is a state where the body’s glucose metabolism is compromised. AMP‐activated protein kinase, or AMPK, has an important part to play in glucose metabolism, and the liver kinase B1 (LKB1) protein functions as a major upstream kinase for AMPK activation, thereby making it appealing therapeutic targets for treating and ...
Rumman Reza, Md. Nazmus Samdani, Niaz Morshed, Raihana Haque Jebin, Imtiaz Ahmed, Md. Selim Reza, Harleen Khatra   +6 more
wiley   +1 more source