Results 51 to 60 of about 755 (153)

The Chemistry of Grandifoline, a Bisindole Alkaloid

, 1979
Department of Pure Chemistry, University College of Science, 92, Acharya P. C.
openaire   +2 more sources

Synthesis of Alkaloids and Compounds Containing the 3,4‐Benzomorphan Scaffold

European Journal of Organic Chemistry, Volume 27, Issue 1, January 2, 2024.
This review summarizes the biosynthesis and the synthesis of several biologically active natural compounds (i. e., alkaloids) and other related compounds containing the hexahydro‐2,6‐methano‐1‐benzazocine structure (i. e., 3,4‐benzomorphan scaffold). Abstract Several natural products, bearing an embedded hexahydro‐2,6‐methano‐1‐benzazocine framework (3,
Laura G. Rodríguez, Josep Bonjoch, Ben Bradshaw   +2 more
wiley   +1 more source

Mechanism of ferroptosis in breast cancer and research progress of natural compounds regulating ferroptosis

Journal of Cellular and Molecular Medicine, Volume 28, Issue 1, January 2024.
Abstract Breast cancer is the most prevalent cancer worldwide and its incidence increases with age, posing a significant threat to women's health globally. Due to the clinical heterogeneity of breast cancer, the majority of patients develop drug resistance and metastasis following treatment.
Anqi Ge, Qi He, Da Zhao, Yuwei Li, Junpeng Chen, Ying Deng, Wang Xiang, Hongqiao Fan, Shiting Wu, Yan Li, Lifang Liu, Yue Wang   +11 more
wiley   +1 more source

The Raputindoles: Novel Cyclopentyl Bisindole Alkaloids from Raputia simulans

Organic Letters, 2010
A novel class of bisindole alkaloids is established by the isolation and structural determination of raputindoles A-D (1-4) from the Amazonian plant Raputia simulans Kallunki (Rutaceae). Complete spectroscopic characterization was accomplished by means of NMR spectroscopy and APCI (+) HRMS.
Vougogiannopoulou, K., Fokialakis, N., Aligiannis, N., Cantrell, C., Skaltsounis, A.-L.   +4 more
openaire   +3 more sources

Antibacterial and Antioxidant Efficacies of Secondary Metabolites from the Roots of Cyphostemma adenocaule: A Combined In Vitro and In Silico Study

Journal of Tropical Medicine, Volume 2024, Issue 1, 2024.
Cyphostemma adenocaule is a therapeutic plant traditionally used to treat rabies, snake bite, diarrhea, and wound healing. To address the bioactive compounds exhibiting these activities, we performed a comprehensive study on the roots of the plant.
Hadush Gebrehiwot, Yadessa Melaku, Muhdin Aliye, Urgessa Ensermu, Aman Dekebo, Milkyas Endale, Daniel Rentsch, Mo Hunsen, Zhengwei Huang   +8 more
wiley   +1 more source

Circular dichroism studies of bisindole Vinca alkaloids

Tetrahedron, 1998
Abstract The analysis of a series of seventeen vinblastine analogs by circular dichroism is described. Exciton coupling of the indole and indoline chromophores of these compounds provides a general, non-empirical method for the assignment of the C16′ configuration with the bioactive C16′-S and the inactive C16′-R analogs giving rise, respectively, to
Craig A. Parish, Jian-Guo Dong, William G. Bornmann, Joan Chang, Koji Nakanishi, Nina Berova   +5 more
openaire   +1 more source

A quorum sensing antagonist with dual bacterium- and host-directed anti-pathogenic activity against Pseudomonas aeruginosa

Virulence
Pseudomonas aeruginosa is a major opportunistic pathogen whose clinical management is increasingly compromised by antibiotic resistance and biofilm-associated persistence.
Dan-Dan Li, Huiyan Li, Wen-Xin Niu, Huayue Li, Joon-Hee Lee   +4 more
doaj   +1 more source

Conofolidine: A Natural Plant Alkaloid That Causes Apoptosis and Senescence in Cancer Cells

Molecules
Natural products contribute substantially to anticancer therapy; the plant kingdom provides an important source of molecules. Conofolidine is a novel Aspidosperma-Aspidosperma bisindole alkaloid isolated from the Malayan plant Tabernaemontana corymbosa ...
Mohammed Zuhair Al-Hayali, Choy-Eng Nge, Kuan Hon Lim, Hilary M. Collins, Toh-Seok Kam, Tracey D. Bradshaw   +5 more
doaj   +1 more source

Synthesis of Topsentin‐A, A Bisindole Alkaloid of the Marine Sponge Topsentia genitrix

Bulletin des Sociétés Chimiques Belges, 1987
AbstractThe synthesis of topsentin‐A, a bisindole alkaloid isolated from the maring sponge Topsentia genitrix, has been achieved starting from 3‐acetylindole.
Braekman, Jean Claude, Daloze, Désiré, Stoller, Catherine   +2 more
openaire   +3 more sources

Effect and Structure-Activity Relationship Between Isatin and its Dimer Indirubin on Neural Development of Transgenic Zebrafish

Natural Product Communications
Objective Isatin (2,3-indolinedione, ISA), as an indole oxide, is widely distributed in mammalian tissues and fluids, with concentrations varying from less than 0.1 to greater than 10 μM. Indirubin (2-(2-oxo-1h-indol-3-ylidene)-1h-indol-3-one, IND), as a
Yonghua Liu, Ke Zhou, Peida Feng, Chenli Xu, Jiayu Zhou, Chengniu Wang, Xiaofang Tan, Ying Chen   +7 more
doaj   +1 more source