Antemitotic activity of strychnopentamine, a bisindolic alkaloid
Journal of Ethnopharmacology, 1984 Strychnopentamine has been tested for its cytotoxic and antitumor activities and compared with two other bisindolic alkaloids that possess an usambarane skeleton. The presence of a N-methylpyrrolidine group increases the antimitotic activity of this type of alkaloids.
Tits, Monique +4 more
openaire +3 more sources
Antimicrobial activities of secondary metabolites of endophytic fungi isolated from Catharanthus roseus [PDF]
, 2017 Introduction: Recently, several endophytes have been shown to possess the potentials to synthesize novel bioactive compounds that have found use for drug discovery. We isolated endophytic fungi associated with Catharanthus roseus collected from the river
Abba, Chika C. +6 more
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Cell type matters : competence for alkaloid metabolism differs in two seed-derived cell strains of Catharanthus roseus [PDF]
, 2023 Since the discovery of the anticancer drugs vinblastine and vincristine, Catharanthus roseus has been intensively studied for biosynthesis of several terpene indole alkaloids (TIAs).
Bunzel, Mirko +7 more
core +1 more source
Spasmolytic Effect of Caulerpine Involves Blockade of Ca2+ Influx on Guinea Pig Ileum
Marine Drugs, 2013 In this work, we investigated the spasmolytic effect of caulerpine, a bisindole alkaloid isolated from marine algae of the Caulerpa genus, on guinea pig ileum.
Magna Suzana Alexandre-Moreira +9 more
doaj +1 more source
Review: Marine natural products [PDF]
, 2005 This review covers the literature published in 2003 for marine natural products, with 619 citations (413 for the period January to December 2003) referring to compounds isolated from marine microorganisms and phytoplankton, green algae, brown algae, red ...
Blunt, John W. +4 more
core +3 more sources
Phenotype Screening of an Azole-bisindole Chemical Library Identifies URB1483 as a New Antileishmanial Agent Devoid of Toxicity on Human Cells [PDF]
, 2021 We report the evaluation of a small library of azole-bisindoles for their antileishmanial potential, in terms of efficacy on Leishmania infantum promastigotes and intracellular amastigotes. Nine compounds showed good activity on L.
Buffi G. +10 more
core +4 more sources
Screening for Bioactive Compounds from Algae [PDF]
, 2012 At present, functional foods are seen as a good alternative to maintain or even improve human health, mainly for the well-known correlation between diet and health.
Herrero, Miguel +3 more
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Cell type matters: competence for alkaloid metabolism differs in two seed-derived cell strains of Catharanthus roseus [PDF]
, 2022 Since the discovery of the anticancer drugs vinblastine and vincristine, Catharanthus roseus has been intensively studied for biosynthesis of several terpene indole alkaloids (TIAs).
Bunzel, Mirko +7 more
core +2 more sources
CHIMIA, 2014 Trigonoliimines are hexacyclic bisindole alkaloids isolated recently by Hao and co-workers. A synthesis of (±)-trigonoliimine B was accomplished in seven steps from simple starting materials featuring the Bischler-Napieralski reaction for ...
Thomas Buyck, Qian Wang, Jieping Zhu
doaj +1 more source
Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis. [PDF]
, 2016 The use of photochemical transformations is a powerful strategy that allows for the formation of a high degree of molecular complexity from relatively simple building blocks in a single step. A central feature of all light-promoted transformations is the
Kärkäs, Markus D. +2 more
core +2 more sources