Results 61 to 70 of about 48,569 (170)
From data to discovery: leveraging big data in plant natural products biosynthesis research
The Plant Journal, Volume 122, Issue 6, June 2025.SUMMARY Plant natural products or specialized metabolites play a vital role in drug discovery and development, with many clinically important derivatives such as the anticancer drugs topotecan (derived from the natural alkaloid camptothecin) and etoposide (derived from the natural polyphenol podophyllotoxin).
Matthew McConnachie +4 more
wiley +1 more source
Food Science &Nutrition, Volume 12, Issue 12, Page 9951-9973, December 2024.This study discussed the therapeutic capacity of various polyphenols, terpenoids, and alkaloids on CRC via the PI3K/Akt/mTOR pathway. Each bioactive component causes various physiological processes, such as triggering free radical production, disruption of mitochondrial membrane potential, cell cycle arrest, inhibition of CRC stem cell migration ...
Kübra Demir +4 more
wiley +1 more source
Bisleuconothine A, an eburnane-aspidosperma bisindole alkaloid from Leuconotis griffithii
, 2010 A new bisindole alkaloid, bisleuconothine A(1) consisting of an eburnane-aspidosperma type skeleton, was isolated from the bark of Leuconotis griffithii.
Arai, T. +11 more
core +1 more source
Mechanochemistry in Organic Synthesis: An Italian Journey through Innovations
European Journal of Organic Chemistry, Volume 27, Issue 30, August 12, 2024.The contribution of Italy to the development of mechanochemistry dates back to 1988 with the first studies on metal alloys. With the progress of time, it has flourished not only in the field of organic chemistry, but also in other scientific fields due to the enormous interest of Italian researchers in the various advantages brought by this technique ...
Francesco Basoccu +2 more
wiley +1 more source
First De Novo Synthesis of the Bisindole Alkaloid Vinblastine.
ChemInform, 2002 AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire +4 more sources
Molecular Networking‐Guided Discovery of Kyonggic Acids in Massilia spp.
European Journal of Organic Chemistry, Volume 27, Issue 17, May 3, 2024.The metabolomes of six Massilia strains were analyzed using a molecular‐networking guided approach, revealing interconnections among metabolites. A closer inspection of the most promising strains led to the discovery of novel N‐acylated amino acids, termed kyonggic acids.
Till Steinmetz +3 more
wiley +1 more source
A pair of novel bisindole alkaloid enantiomers from marine fungus Fusarium sp. XBB-9
, 2019 A preliminary research on the marine fungus Fusarium sp. XBB-9 resulted in a pair of novel bisindole alkaloid enantiomers, (+)- and (–)-fusaspoid A (1a/1b) and 12 diverse compounds.
Wen-Jian Lan (1490500) +3 more
core +1 more source
BiomoleculesCandidiasis is considered an emerging public health concern because of the occurrence of drug-resistant Candida strains and the lack of an available structurally diverse antifungal drug armamentarium.
Joe Anthony H. Manzano +4 more
doaj +1 more source
The Plant Genome, Volume 17, Issue 1, March 2024.Abstract Terpenoids are the main active components in the Zanthoxylum armatum leaves, which have extensive medicinal value. The Z. armatum leaf is the main by‐product in the Z. armatum industry. However, the transcription factors involved in the biosynthesis of terpenoids are rarely reported.
Xiaomeng Liu +9 more
wiley +1 more source
The Raputindoles: Novel Cyclopentyl Bisindole Alkaloids from Raputia simulans
Organic Letters, 2010 A novel class of bisindole alkaloids is established by the isolation and structural determination of raputindoles A-D (1-4) from the Amazonian plant Raputia simulans Kallunki (Rutaceae). Complete spectroscopic characterization was accomplished by means of NMR spectroscopy and APCI (+) HRMS.
Vougogiannopoulou, K. +4 more
openaire +3 more sources