Cathagines A–D, new bisindole alkaloids from Catharanthus roseus
Four new bisindole alkaloids, cathagines A (1)-D (4) consisting of an aspidosperma and the fused tetracyclic 3-spirooxindole derived from an iboga type skeleton were isolated from the whole plant of Catharanthus roseus. The structures including absolute stereochemistry were elucidated on the basis of 2D NMR data and CD spectra.
Yusuke, Hirasawa +8 more
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Indirubin, a bisindole alkaloid from Isatis indigotica, reduces H1N1 susceptibility in stressed mice by regulating MAVS signaling. [PDF]
Jie C +9 more
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Bisleuconothine A, a bisindole alkaloid, inhibits colorectal cancer cell in vitro and in vivo targeting Wnt signaling. [PDF]
Kong LM +8 more
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NaHMDS/B(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub>-promoted diastereoselective Friedel-Crafts alkylation of indoles/pyrroles with <i>N-tert</i>-butanesulfinylimines: towards the asymmetric synthesis of bisindole alkaloid Calcicamide B. [PDF]
Zhang G +11 more
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Total Synthesis of (-)-Owerreine and (-)-Anhydrovobtusine. [PDF]
Myeong IS, Pinto T, Movassaghi M.
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Stereochemical Analysis of Natural Products: Bisindole Alkaloids of the <i>Strychnos-Strychnos</i> Type. [PDF]
Grigoriev DA +3 more
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Total Synthesis of Strempeliopidine and Non-Natural Stereoisomers through a Convergent Petasis Borono-Mannich Reaction. [PDF]
Rand AW +4 more
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Arylation of Olefins with N-Unprotected Bromobisindole Ethanamines: Expanding the Scope of the Mizoroki-Heck Reaction. [PDF]
Buono A +5 more
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Studies on the synthesis of bisindole Aspidosperma alkaloids
I. Introduction and Background on Aspidosperma Alkaloids A brief overview of monoterpene indole Aspidosperma alkaloids is discussed. The biosynthesis of the characteristic pentacyclic core from tryptamine and secologanin is summarized. Some representative examples of total syntheses of Aspidosperma alkaloids are discussed.
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