Results 81 to 90 of about 1,516 (198)
BiomoleculesCandidiasis is considered an emerging public health concern because of the occurrence of drug-resistant Candida strains and the lack of an available structurally diverse antifungal drug armamentarium.
Joe Anthony H. Manzano +4 more
doaj +1 more source
Synthesis of Alkaloids and Compounds Containing the 3,4‐Benzomorphan Scaffold
European Journal of Organic Chemistry, Volume 27, Issue 1, January 2, 2024.This review summarizes the biosynthesis and the synthesis of several biologically active natural compounds (i. e., alkaloids) and other related compounds containing the hexahydro‐2,6‐methano‐1‐benzazocine structure (i. e., 3,4‐benzomorphan scaffold). Abstract Several natural products, bearing an embedded hexahydro‐2,6‐methano‐1‐benzazocine framework (3,
Laura G. Rodríguez +2 more
wiley +1 more source
Calmodulin in Complex with Proteins and Small Molecule Ligands: Operating with the Element of Surprise. Implications for Structure-Based Drug Design [PDF]
, 2009 Calmodulin plays a role in several life processes, its flexibility allows binding of a number of different ligands from small molecules to amphiphilic peptide helices and proteins. Through the diversity of its functions, it is quite difficult to find new
Keserű, György Miklós +2 more
core
Journal of Cellular and Molecular Medicine, Volume 28, Issue 1, January 2024.Abstract Breast cancer is the most prevalent cancer worldwide and its incidence increases with age, posing a significant threat to women's health globally. Due to the clinical heterogeneity of breast cancer, the majority of patients develop drug resistance and metastasis following treatment.
Anqi Ge +11 more
wiley +1 more source
First De Novo Synthesis of the Bisindole Alkaloid Vinblastine.
ChemInform, 2002 AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire +4 more sources
Circular dichroism studies of bisindole Vinca alkaloids
Tetrahedron, 1998 Abstract The analysis of a series of seventeen vinblastine analogs by circular dichroism is described. Exciton coupling of the indole and indoline chromophores of these compounds provides a general, non-empirical method for the assignment of the C16′ configuration with the bioactive C16′-S and the inactive C16′-R analogs giving rise, respectively, to
Craig A. Parish +5 more
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Journal of Tropical Medicine, Volume 2024, Issue 1, 2024.Cyphostemma adenocaule is a therapeutic plant traditionally used to treat rabies, snake bite, diarrhea, and wound healing. To address the bioactive compounds exhibiting these activities, we performed a comprehensive study on the roots of the plant.
Hadush Gebrehiwot +8 more
wiley +1 more source
Alkaloids: an overview of their antibacterial, antibiotic-enhancing and antivirulence activities. [PDF]
, 2014 With reports of pandrug-resistant bacteria causing untreatable infections, the need for new antibacterial therapies is more pressing than ever. Alkaloids are a large and structurally diverse group of compounds that have served as scaffolds for important ...
Cushnie, Benjamart +2 more
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A Review on Tabernaemontana spp.: Multipotential Medicinal Plant [PDF]
, 2018 Tabernaemontana is one of the genera that is used in Chinese, Ayurvedic and Thai traditional medicine for the treatment several diseases. From a chemical point of view, the great majority of Tabernaemontana species have already been subjected to ...
Athipornchai, Anan
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Rare Bisindole Alkaloids from the Amazonian Tree Raputia simulans
Chemistry & Biodiversity, 2014 AbstractThe stem bark of Raputia simulans (Rutaceae) has been reported to contain simple and dimeric indole alkaloids. Further phytochemical investigation of R. simulans stem bark resulted in the isolation of three new alkaloids. These compounds represent a relatively new category of dimeric indole alkaloids with a cyclohexene moiety in their core ...
Vougogiannopoulou, K. +3 more
openaire +3 more sources