Results 11 to 20 of about 1,592 (193)

Bisindole Compounds—Synthesis and Medicinal Properties [PDF]

Antibiotics
The indole nucleus stands out as a pharmacophore, among other aromatic heterocyclic compounds with remarkable therapeutic properties, such as benzimidazole, pyridine, quinoline, benzothiazole, and others.
Maria Marinescu
doaj   +5 more sources

A Convenient Synthesis of 3,7′-Bisindole Derivatives [PDF]

Molecules, 2016
An efficient and convenient method to synthesize highly functionalized 3,7′-bisindole derivatives has been developed via a Michael addition and cyclic condensation reaction of heterocyclic ketene aminals (HKAs) with 2-(1H-indol-3-yl)cyclohexa-2,5-diene-1,
Teng Liu, Hong-You Zhu, Da-Yun Luo, Sheng-Jiao Yan, Jun Lin   +4 more
doaj   +4 more sources

One‐Pot Synthesis of Novel β‐Carboline‐{α‐Acylaminoamide}‐Bisindole Derivatives: Antibacterial Evaluation, Molecular Docking, and Density Functional Theory Studies [PDF]

ChemistryOpen
A new series of β‐carboline‐{α‐acylaminoamide}‐bisindole hybrids (12a–l) is designed and synthesized employing an atom‐economical one‐pot Ugi four‐component reaction (U‐4CR), affording the target compounds in good yields. All synthesized compounds (12a–l)
Ankit Kumar Atri, Lavanya Khullar, Gobind Kumar, Sahil Mishra, Tamanna Dua, Vinay Singh, Kusum Harjai, Parvesh Singh, Vasundhara Singh   +8 more
doaj   +3 more sources

Bisindole alkaloids from Voacanga grandifolia leaves [PDF]

Journal of Natural Medicines, 2021
Two new bisindole alkaloids, 12'-O-demethyl-vobtusine-5-lactam and isovobtusine-N-oxide (1 and 2), were isolated from the leaves of Voacanga grandifolia, together with two known bisindole alkaloids. Their structures were elucidated on the basis of 1D and 2D NMR data. 1 and 2 showed potent antimalarial activity against Plasmodium falciparum 3D7 and very
Alfarius Eko Nugroho, -, Yurika Ono, -, Eunji Jin, -, Yusuke Hirasawa, -, Toshio Kaneda, -, Abdul Rahman, -, Idha Kusumawati, -, Takahiro Tougan, -, Toshihiro Horii, -, Noor Cholies Zaini, -, Hiroshi Morita, -   +10 more
openaire   +4 more sources

Rapid Access to an Enantioenriched Spiro Bisindole Directly from Indole and Acetone. [PDF]

Angew Chem Int Ed Engl
A catalytic enantioselective one‐pot “self‐assembly” strategy was developed for the exceedingly convenient access to a spiro bisindole directly from indole and acetone. The obtained enantiopure C2‐symmetric bisindole showed exceptional performance as a chiral backbone of diverse effective catalysts or ligands. Abstract Disclosed here is a “one‐pot self‐
Wang JY, Lin J, Zhang C, Sun J.
europepmc   +4 more sources

Bio-informed synthesis of marine-sourced indole derivatives: suppressing gram-negative bacteria biofilm and virulence [PDF]

BMC Biology
Biofilms cling to surfaces to form complex architectures allowing their bacterial creators to acquire multidrug resistance and claiming countless lives worldwide.
Karina Golberg, Kamal Elouarzaki, Bat-el Kagan, Marilou Shagan, Netta Shemesh, Esti Kramarsky-Winter, Anat Ben-Zvi, Yaffa Mizrachi Nebenzahl, Robert S. Marks, Ariel Kushmaro   +9 more
doaj   +2 more sources

Divergent Pathways in the Biosynthesis of Bisindole Natural Products

Chemistry & Biology, 2009
Two molecules of the amino acid L-tryptophan are the biosynthetic precursors to a class of natural products named the "bisindoles." Hundreds of these bisindole molecules have been isolated from natural sources, and many of these molecules have potent medicinal properties.
Ryan, Katherine S., Drennan, Catherine L
openaire   +5 more sources

Elucidation and derivatisation of bisindole biosynthesis pathways [PDF]

, 2019
Bisindole natural products encompass the well-studied indolocarbazoles, such as rebeccamycin and staurosporine, among other minor classes including indolotryptolines and bisindolylpyrroles. Bisindole biosynthesis starts from L-tryptophan and forms highly aromatic bisindole scaffolds in a series of biosynthetic steps, which are catalysed by various core
Lai, Hung En
openaire   +3 more sources

CrERF5, an AP2/ERF Transcription Factor, Positively Regulates the Biosynthesis of Bisindole Alkaloids and Their Precursors in Catharanthus roseus

Frontiers in Plant Science, 2019
Catharanthus roseus contains a variety of monoterpenoid indole alkaloids (MIAs), among which bisindole alkaloids vinblastine and vincristine are well-known to have antitumor effects and widely used in clinical treatment.
Qifang Pan, Hang Wang, Xueqing Fu
exaly   +3 more sources

Marine-Derived Bisindoles for Potent Selective Cancer Drug Discovery and Development [PDF]

Molecules
Marine-derived bisindoles exhibit structural diversity and exert anti-cancer influence through multiple mechanisms. Comprehensive research has shown that the development success rate of drugs derived from marine natural products is four times higher than
Mengwei Xu, Zhaofang Bai, Baocheng Xie, Rui Peng, Ziwei Du, Yan Liu, Guangshuai Zhang, Si Yan, Xiaohe Xiao, Shuanglin Qin   +9 more
doaj   +2 more sources