Results 11 to 20 of about 1,055 (166)

A Convenient Synthesis of 3,7′-Bisindole Derivatives [PDF]

Molecules, 2016
An efficient and convenient method to synthesize highly functionalized 3,7′-bisindole derivatives has been developed via a Michael addition and cyclic condensation reaction of heterocyclic ketene aminals (HKAs) with 2-(1H-indol-3-yl)cyclohexa-2,5-diene-1,
Teng Liu, Hong-You Zhu, Da-Yun Luo, Sheng-Jiao Yan, Jun Lin   +4 more
doaj   +3 more sources

Design, Synthesis and Application of Chiral Spirocyclic Bisindoles

Angewandte Chemie, Volume 137, Issue 15, April 7, 2025.
Chiral spirocyclic bisindoles have been designed and synthesized by asymmetric spirocyclization of the corresponding linear ketones by either chiral phosphoric acid catalysis or Rh‐catalyzed asymmetric arylation followed by simple Lewis acid catalysis.
Jing‐Yi Wang, Jianwei Sun
wiley   +4 more sources

Rapid Access to an Enantioenriched Spiro Bisindole Directly from Indole and Acetone. [PDF]

Angew Chem Int Ed Engl
A catalytic enantioselective one‐pot “self‐assembly” strategy was developed for the exceedingly convenient access to a spiro bisindole directly from indole and acetone. The obtained enantiopure C2‐symmetric bisindole showed exceptional performance as a chiral backbone of diverse effective catalysts or ligands. Abstract Disclosed here is a “one‐pot self‐
Wang JY, Lin J, Zhang C, Sun J.
europepmc   +3 more sources

Efficient and Rapid Arylation of NH₂-Unprotected Bromobisindole Ethanamines via Suzuki-Miyaura Coupling: Generating New Leads Against Leishmania. [PDF]

Chemistry
A library of novel bisindole derivatives was synthesized through an optimized rapid Suzuki‐Miyaura coupling reaction, utilizing NH2‐unprotected bromobisindole ethanamines and boronic acids with yields up to 93%. The compounds were screened for their activity against L. infantum promastigotes.
Buono A, Diotallevi A, Maestrini S, Verboni M, Kiuru P, Galluzzi L, Duranti A, Olivieri D, Lucarini S.   +8 more
europepmc   +2 more sources

Bisindoles. 21. Synthesis and alkylation of some tetramethyl-substituted bisindoles [PDF]

Chemistry of Heterocyclic Compounds, 1985
2,3,2′,3′-Tetramethyl-substituted bisindoles and their 1,1′-dimethyl derivatives were synthesized. The latter were obtained in high yield by interphase alkylation of the bisindoles. The spectral characteristics of the synthesized bisindoles were studied.
M. G. Chesmaritashvili, Sh. A. Samsoniya, E. A. Ageev, E. N. Gordeev, L. N. Kuleshova, T. A. Kozik, N. N. Suvorov   +6 more
  +6 more sources

Combined Transcriptomic and Metabolomic Analysis Reveals an Ethylene-Activated Regulatory Model on Monoterpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus. [PDF]

Plant Biotechnol J
ABSTRACT Catharanthus roseus contains nearly 200 bioactive monoterpenoid indole alkaloids (MIAs) that are effective in treating cancer and other diseases. Ethylene plays a significant role in enhancing MIA biosynthesis, and we have found that it greatly induces the accumulation of anhydrovinblastine.
Deng B, Miao Q, Ou C, Pan Y, Liu H, Fu X, Li L, Wang Y, Tang K, Pan Q.   +9 more
europepmc   +2 more sources

Discovery of Barakacin and Its Derivatives as Novel Antiviral and Fungicidal Agents

Molecules, 2023
Pesticides are essential for the development of agriculture. It is urgent to develop green, safe and efficient pesticides. Bisindole alkaloids have unique and concise structures and broad biological activities, which make them an important leading ...
Yongyue Gao, Xingxing He, Lili Yan, Hongyu Zhang, Sijia Liu, Qian Ma, Peiyao Zhang, Yan Zhang, Zijun Zhang, Ziwen Wang, Aidang Lu, Qingmin Wang   +11 more
doaj   +1 more source

Concise Syntheses of Marine (Bis)indole Alkaloids Meridianin C, D, F, and G and Scalaridine A via One-Pot Masuda Borylation-Suzuki Coupling Sequence

Molecules, 2022
N-Protected 3-iodoindoles were reacted with (di)azine halides in a sequentially Pd-catalyzed one-pot fashion, i.e., by Masuda borylation–Suzuki coupling (MBSC) sequence.
Marco Kruppa, Gereon A. Sommer, Thomas J. J. Müller   +2 more
doaj   +1 more source

CrERF5, an AP2/ERF Transcription Factor, Positively Regulates the Biosynthesis of Bisindole Alkaloids and Their Precursors in Catharanthus roseus

Frontiers in Plant Science, 2019
Catharanthus roseus contains a variety of monoterpenoid indole alkaloids (MIAs), among which bisindole alkaloids vinblastine and vincristine are well-known to have antitumor effects and widely used in clinical treatment.
Qifang Pan, Chenyi Wang, Zhiwei Xiong, Hang Wang, Xueqing Fu, Qian Shen, Bowen Peng, Yanan Ma, Xiaofen Sun, Kexuan Tang   +9 more
doaj   +1 more source

Emerging Roles of Adenosine Metabolism in Astrocytes During Brain Injury. [PDF]

CNS Neurosci Ther
Adenosine, as a key metabolic and neurotransmitter in the brain, has become an important therapeutic target for improving the efficacy of immunotherapy for stroke. However, gaps in knowledge about its metabolic pathways have become a key factor limiting its clinical translation.
Zhu S, Zhong S, Lin X, Zhao C, Li Y.
europepmc   +2 more sources