Results 11 to 20 of about 2,045 (191)

A Convenient Synthesis of 3,7′-Bisindole Derivatives [PDF]

Molecules, 2016
An efficient and convenient method to synthesize highly functionalized 3,7′-bisindole derivatives has been developed via a Michael addition and cyclic condensation reaction of heterocyclic ketene aminals (HKAs) with 2-(1H-indol-3-yl)cyclohexa-2,5-diene-1,
Teng Liu, Hong-You Zhu, Da-Yun Luo, Sheng-Jiao Yan, Jun Lin   +4 more
doaj   +3 more sources

Two new bisindole alkaloids from Tabernaemontana macrocarpa Jack [PDF]

Journal of Natural Medicines, 2021
Two new bisindole alkaloids, bisnaecarpamines A (1) and B (2), possessing a vobasine-sarpagine type skeleton were isolated from the bark of Tabernaemontana macrocarpa Jack.
Puteri Amelia, A. E. Nugroho, Y. Hirasawa, Toshio Kaneda, T. Tougan, T. Horii, H. Morita   +6 more
semanticscholar   +3 more sources

Design, Synthesis and Application of Chiral Spirocyclic Bisindoles

Angewandte Chemie
AbstractWhile modifications of the privileged catalyst backbones, such as 1,1’‐spirobiindane‐7,7’‐diol (SPINOL), have led to the development of diverse useful chiral catalysts, the incorporation of heteroarenes in such chiral spirocyclic structures has limitedly known.
Jing‐Yi Wang, Jianwei Sun
wiley   +4 more sources

Efficient and Rapid Arylation of NH₂-Unprotected Bromobisindole Ethanamines via Suzuki-Miyaura Coupling: Generating New Leads Against Leishmania. [PDF]

Chemistry
A library of novel bisindole derivatives was synthesized through an optimized rapid Suzuki‐Miyaura coupling reaction, utilizing NH2‐unprotected bromobisindole ethanamines and boronic acids with yields up to 93%. The compounds were screened for their activity against L. infantum promastigotes.
Buono A, Diotallevi A, Maestrini S, Verboni M, Kiuru P, Galluzzi L, Duranti A, Olivieri D, Lucarini S.   +8 more
europepmc   +2 more sources

Bisindoles. 21. Synthesis and alkylation of some tetramethyl-substituted bisindoles [PDF]

Chemistry of Heterocyclic Compounds, 1985
2,3,2′,3′-Tetramethyl-substituted bisindoles and their 1,1′-dimethyl derivatives were synthesized. The latter were obtained in high yield by interphase alkylation of the bisindoles. The spectral characteristics of the synthesized bisindoles were studied.
M. G. Chesmaritashvili, Sh. A. Samsoniya, E. A. Ageev, E. N. Gordeev, L. N. Kuleshova, T. A. Kozik, N. N. Suvorov   +6 more
  +6 more sources

Combined Transcriptomic and Metabolomic Analysis Reveals an Ethylene-Activated Regulatory Model on Monoterpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus. [PDF]

Plant Biotechnol J
ABSTRACT Catharanthus roseus contains nearly 200 bioactive monoterpenoid indole alkaloids (MIAs) that are effective in treating cancer and other diseases. Ethylene plays a significant role in enhancing MIA biosynthesis, and we have found that it greatly induces the accumulation of anhydrovinblastine.
Deng B, Miao Q, Ou C, Pan Y, Liu H, Fu X, Li L, Wang Y, Tang K, Pan Q.   +9 more
europepmc   +2 more sources

Dimethyl 3,3′-[(4-nitrophenyl)methylene]bis(1H-indole-2-carboxylate) ethanol hemisolvate

IUCrData, 2021
There are two main molecules in asymmetric unit of the title compound, C27H21N3O6·0.5C2H5OH. In both, the indole ring systems are approximately perpendicular to each other, at dihedral angles of 69.3 (5) and 82.8(4)°. In the crystal, molecules are linked
Yu-Long Li, Jin Zhou, Hong Jiang, Hong-Shun Sun, Rui-Zhe Li, Sha-Li Liu, Xu-Dong Zhang   +6 more
doaj   +1 more source

Novel Small-Molecule Hybrid-Antibacterial Agents against S. aureus and MRSA Strains

Molecules, 2021
Ongoing resistance developments against antibiotics that also affect last-resort antibiotics require novel antibacterial compounds. Strategies to discover such novel structures have been dimerization or hybridization of known antibacterial agents.
Robin Gehrmann, Tobias Hertlein, Elisa Hopke, Knut Ohlsen, Michael Lalk, Andreas Hilgeroth   +5 more
doaj   +1 more source

Diethyl 3,3′-[(3-fluorophenyl)methylene]bis(1H-indole-2-carboxylate)

IUCrData, 2020
In the title compound, C29H25FN2O4, the mean planes of the indole ring systems are approximately perpendicular to one another [dihedral angle = 88.3 (4)°]. The benzene ring is twisted with respect to the indole ring systems by 49.8 (5) and 77.6 (3)°.
Hong Jiang, Yu-Long Li, Jin Zhou, Hong-Shun Sun, Qing-Yu Zhang, Xing-Hao Shi, Zhi-Yuan Zhang, Tian Ling   +7 more
doaj   +1 more source

Discovery of Barakacin and Its Derivatives as Novel Antiviral and Fungicidal Agents

Molecules, 2023
Pesticides are essential for the development of agriculture. It is urgent to develop green, safe and efficient pesticides. Bisindole alkaloids have unique and concise structures and broad biological activities, which make them an important leading ...
Yongyue Gao, Xingxing He, Lili Yan, Hongyu Zhang, Sijia Liu, Qian Ma, Peiyao Zhang, Yan Zhang, Zijun Zhang, Ziwen Wang, Aidang Lu, Qingmin Wang   +11 more
doaj   +1 more source