Results 11 to 20 of about 1,797 (189)

A Convenient Synthesis of 3,7′-Bisindole Derivatives [PDF]

Molecules, 2016
An efficient and convenient method to synthesize highly functionalized 3,7′-bisindole derivatives has been developed via a Michael addition and cyclic condensation reaction of heterocyclic ketene aminals (HKAs) with 2-(1H-indol-3-yl)cyclohexa-2,5-diene-1,
Teng Liu, Hong-You Zhu, Da-Yun Luo, Sheng-Jiao Yan, Jun Lin   +4 more
doaj   +4 more sources

Bisindole alkaloids from Voacanga grandifolia leaves [PDF]

Journal of Natural Medicines, 2021
Two new bisindole alkaloids, 12'-O-demethyl-vobtusine-5-lactam and isovobtusine-N-oxide (1 and 2), were isolated from the leaves of Voacanga grandifolia, together with two known bisindole alkaloids. Their structures were elucidated on the basis of 1D and 2D NMR data. 1 and 2 showed potent antimalarial activity against Plasmodium falciparum 3D7 and very
Alfarius Eko Nugroho, -, Yurika Ono, -, Eunji Jin, -, Yusuke Hirasawa, -, Toshio Kaneda, -, Abdul Rahman, -, Idha Kusumawati, -, Takahiro Tougan, -, Toshihiro Horii, -, Noor Cholies Zaini, -, Hiroshi Morita, -   +10 more
openaire   +4 more sources

Divergent Pathways in the Biosynthesis of Bisindole Natural Products [PDF]

Chemistry & Biology, 2009
Two molecules of the amino acid L-tryptophan are the biosynthetic precursors to a class of natural products named the "bisindoles." Hundreds of these bisindole molecules have been isolated from natural sources, and many of these molecules have potent medicinal properties.
Ryan, Katherine S., Drennan, Catherine L
openaire   +5 more sources

Elucidation and derivatisation of bisindole biosynthesis pathways [PDF]

, 2019
Bisindole natural products encompass the well-studied indolocarbazoles, such as rebeccamycin and staurosporine, among other minor classes including indolotryptolines and bisindolylpyrroles. Bisindole biosynthesis starts from L-tryptophan and forms highly aromatic bisindole scaffolds in a series of biosynthetic steps, which are catalysed by various core
Lai, Hung En
openaire   +3 more sources

The Chemistry of Grandifoline, a Bisindole Alkaloid

, 1979
Department of Pure Chemistry, University College of Science, 92, Acharya P. C.
(Mrs.) A. CHATTERJEE
openaire   +3 more sources

Design, Synthesis and Application of Chiral Spirocyclic Bisindoles

Angewandte Chemie, Volume 137, Issue 15, April 7, 2025.
Chiral spirocyclic bisindoles have been designed and synthesized by asymmetric spirocyclization of the corresponding linear ketones by either chiral phosphoric acid catalysis or Rh‐catalyzed asymmetric arylation followed by simple Lewis acid catalysis.
Jing‐Yi Wang, Jianwei Sun
wiley   +4 more sources

Chapter 4 Bisindole Alkaloids

, 2006
Publisher Summary This chapter provides an overview on bisindole alkaloids. The indole–indole and tryptamine–tryptamine type, and related alkaloids are discussed. Tryptamine–tryptamine type with an additional monoterpene unit and related alkaloids are briefly discussed.
Toh-Seok Kam, Choo, Yeun Mun, Kam, Toh Seok, Yeun-Mun Choo   +3 more
openaire   +2 more sources

Rapid Access to an Enantioenriched Spiro Bisindole Directly from Indole and Acetone. [PDF]

Angew Chem Int Ed Engl
A catalytic enantioselective one‐pot “self‐assembly” strategy was developed for the exceedingly convenient access to a spiro bisindole directly from indole and acetone. The obtained enantiopure C2‐symmetric bisindole showed exceptional performance as a chiral backbone of diverse effective catalysts or ligands. Abstract Disclosed here is a “one‐pot self‐
Wang JY, Lin J, Zhang C, Sun J.
europepmc   +3 more sources

Bisindoles. 21. Synthesis and alkylation of some tetramethyl-substituted bisindoles [PDF]

Chemistry of Heterocyclic Compounds, 1985
2,3,2′,3′-Tetramethyl-substituted bisindoles and their 1,1′-dimethyl derivatives were synthesized. The latter were obtained in high yield by interphase alkylation of the bisindoles. The spectral characteristics of the synthesized bisindoles were studied.
M. G. Chesmaritashvili, Sh. A. Samsoniya, E. A. Ageev, E. N. Gordeev, L. N. Kuleshova, T. A. Kozik, N. N. Suvorov   +6 more
  +6 more sources

Efficient and Rapid Arylation of NH₂-Unprotected Bromobisindole Ethanamines via Suzuki-Miyaura Coupling: Generating New Leads Against Leishmania. [PDF]

Chemistry
A library of novel bisindole derivatives was synthesized through an optimized rapid Suzuki‐Miyaura coupling reaction, utilizing NH2‐unprotected bromobisindole ethanamines and boronic acids with yields up to 93%. The compounds were screened for their activity against L. infantum promastigotes.
Buono A, Diotallevi A, Maestrini S, Verboni M, Kiuru P, Galluzzi L, Duranti A, Olivieri D, Lucarini S.   +8 more
europepmc   +2 more sources