Results 1 to 10 of about 1,561 (163)

Brominated Bisindole Alkaloids from the Celtic Sea Sponge Spongosorites calcicola. [PDF]

Molecules, 2019
As part of an ongoing program to identify new bioactive compounds from Irish marine bioresources, we selected the subtidal sponge Spongosorites calcicola for chemical study, as fractions of this species displayed interesting cytotoxic bioactivities and ...
Jennings LK, Khan NMD, Kaur N, Rodrigues D, Morrow C, Boyd A, Thomas OP.   +6 more
europepmc   +5 more sources

Bisindole Alkaloids from the Alstonia Species: Recent Isolation, Bioactivity, Biosynthesis, and Synthesis. [PDF]

Molecules, 2021
Bisindoles are structurally complex dimers and are intriguing targets for partial and total synthesis. They exhibit stronger biological activity than their corresponding monomeric units.
Pandey KP, Rahman MT, Cook JM.
europepmc   +2 more sources

Two new bisindole alkaloids from Tabernaemontana macrocarpa Jack. [PDF]

J Nat Med, 2021
Two new bisindole alkaloids, bisnaecarpamines A (1) and B (2), possessing a vobasine-sarpagine type skeleton were isolated from the bark of Tabernaemontana macrocarpa Jack. Their structures were elucidated by extensive spectroscopic methods and chemical correlation.
Amelia P, Nugroho AE, Hirasawa Y, Kaneda T, Tougan T, Horii T, Morita H.   +6 more
europepmc   +4 more sources

Marine Alkaloid 2,2-Bis(6-bromo-3-indolyl) Ethylamine and Its Synthetic Derivatives Inhibit Microbial Biofilms Formation and Disaggregate Developed Biofilms [PDF]

Microorganisms, 2019
The antimicrobial activity of the marine bisindole alkaloid 2,2-bis(6-bromo-3-indolyl) ethylamine (1) and related synthetic analogues (compounds 2⁻8) against target microorganisms was investigated by Minimum Inhibitory Concentration (MIC ...
Raffaella Campana, Gianfranco Favi, Wally Baffone, Simone Lucarini   +3 more
doaj   +3 more sources

CrERF5, an AP2/ERF Transcription Factor, Positively Regulates the Biosynthesis of Bisindole Alkaloids and Their Precursors in Catharanthus roseus. [PDF]

Front Plant Sci, 2019
Catharanthus roseus contains a variety of monoterpenoid indole alkaloids (MIAs), among which bisindole alkaloids vinblastine and vincristine are well-known to have antitumor effects and widely used in clinical treatment.
Pan Q, Wang C, Xiong Z, Wang H, Fu X, Shen Q, Peng B, Ma Y, Sun X, Tang K.   +9 more
europepmc   +2 more sources

Synthesis of Bisindole Alkaloids from the Apocynaceae Which Contain a Macroline or Sarpagine Unit: A Review. [PDF]

Molecules, 2016
Bisindole natural products consist of two monomeric indole alkaloid units as their obligate constituents. Bisindoles are more potent with respect to their biological activity than their corresponding monomeric units.
Rahman MT, Tiruveedhula VV, Cook JM.
europepmc   +2 more sources

Cytotoxic Activity, and Molecular Docking of Indole Alkaloid Voacangine and Bisindole Alkaloid Vobtusine, Vobtusine Lactone from the Indonesian Plant: Voacanga foetida (Blume) Rolfe [PDF]

Journal of Natural Products, 2021
The purpose of this study was to isolate and test its cytotoxic activity starting from extract fraction and its isolate compound, then carried out molecular docking to confirm the potential biological activity of ligands (vocangine, vobtusine, and ...
Amelia, Puteri, Dachriyanus, Dachriyanus, Frengki, Frengki, Hirasawa, Yusuke, Ikhtiarudin, Ihsan, Kaneda, Toshio, Morita, Hiroshi, Susanty, Adriani, Wahyuni, Fatma Sri, Yanwirasti, Yanwirasti   +9 more
core   +5 more sources

Marine-Derived Bisindoles for Potent Selective Cancer Drug Discovery and Development. [PDF]

Molecules
Marine-derived bisindoles exhibit structural diversity and exert anti-cancer influence through multiple mechanisms. Comprehensive research has shown that the development success rate of drugs derived from marine natural products is four times higher than
Xu M, Bai Z, Xie B, Peng R, Du Z, Liu Y, Zhang G, Yan S, Xiao X, Qin S.   +9 more
europepmc   +2 more sources

Globospiramine from Voacanga globosa Exerts Robust Cytotoxic and Antiproliferative Activities on Cancer Cells by Inducing Caspase-Dependent Apoptosis in A549 Cells and Inhibiting MAPK14 (p38α): In Vitro and Computational Investigations. [PDF]

Cells
Bisindole alkaloids are a source of inspiration for the design and discovery of new-generation anticancer agents. In this study, we investigated the cytotoxic and antiproliferative activities of three spirobisindole alkaloids from the traditional ...
Manzano JAH, Abellanosa EA, Aguilar JP, Brogi S, Yen CH, Macabeo APG, Austriaco N.   +6 more
europepmc   +2 more sources

Conofolidine: A Natural Plant Alkaloid That Causes Apoptosis and Senescence in Cancer Cells. [PDF]

Molecules
Natural products contribute substantially to anticancer therapy; the plant kingdom provides an important source of molecules. Conofolidine is a novel Aspidosperma-Aspidosperma bisindole alkaloid isolated from the Malayan plant Tabernaemontana corymbosa ...
Al-Hayali MZ, Nge CE, Lim KH, Collins HM, Kam TS, Bradshaw TD.   +5 more
europepmc   +2 more sources