CrERF5, an AP2/ERF Transcription Factor, Positively Regulates the Biosynthesis of Bisindole Alkaloids and Their Precursors in Catharanthus roseus [PDF]
Frontiers in Plant Science, 2019 Catharanthus roseus contains a variety of monoterpenoid indole alkaloids (MIAs), among which bisindole alkaloids vinblastine and vincristine are well-known to have antitumor effects and widely used in clinical treatment.
Xiaofen Sun, Qian Shen, Ma Yanan
exaly +4 more sources
Synthesis of Bisindole Alkaloids from the Apocynaceae Which Contain a Macroline or Sarpagine Unit: A Review [PDF]
Molecules, 2016 Bisindole natural products consist of two monomeric indole alkaloid units as their obligate constituents. Bisindoles are more potent with respect to their biological activity than their corresponding monomeric units.
James Cook, Md Toufiqur Rahman
exaly +4 more sources
Bisindole Alkaloids from the Alstonia Species: Recent Isolation, Bioactivity, Biosynthesis, and Synthesis [PDF]
Molecules, 2021 Bisindoles are structurally complex dimers and are intriguing targets for partial and total synthesis. They exhibit stronger biological activity than their corresponding monomeric units.
Kamal P. Pandey +2 more
doaj +2 more sources
Brominated Bisindole Alkaloids from the Celtic Sea Sponge Spongosorites calcicola [PDF]
Molecules, 2019 As part of an ongoing program to identify new bioactive compounds from Irish marine bioresources, we selected the subtidal sponge Spongosorites calcicola for chemical study, as fractions of this species displayed interesting cytotoxic bioactivities and ...
Laurence K. Jennings +6 more
doaj +2 more sources
Two new bisindole alkaloids from Tabernaemontana macrocarpa Jack. [PDF]
J Nat Med, 2021 Two new bisindole alkaloids, bisnaecarpamines A (1) and B (2), possessing a vobasine-sarpagine type skeleton were isolated from the bark of Tabernaemontana macrocarpa Jack. Their structures were elucidated by extensive spectroscopic methods and chemical correlation.
Amelia P +6 more
europepmc +4 more sources
Marine-Derived Bisindoles for Potent Selective Cancer Drug Discovery and Development [PDF]
MoleculesMarine-derived bisindoles exhibit structural diversity and exert anti-cancer influence through multiple mechanisms. Comprehensive research has shown that the development success rate of drugs derived from marine natural products is four times higher than
Mengwei Xu +9 more
doaj +2 more sources
Globospiramine from Voacanga globosa Exerts Robust Cytotoxic and Antiproliferative Activities on Cancer Cells by Inducing Caspase-Dependent Apoptosis in A549 Cells and Inhibiting MAPK14 (p38α): In Vitro and Computational Investigations [PDF]
CellsBisindole alkaloids are a source of inspiration for the design and discovery of new-generation anticancer agents. In this study, we investigated the cytotoxic and antiproliferative activities of three spirobisindole alkaloids from the traditional ...
Joe Anthony H. Manzano +6 more
doaj +2 more sources
Conofolidine: A Natural Plant Alkaloid That Causes Apoptosis and Senescence in Cancer Cells [PDF]
MoleculesNatural products contribute substantially to anticancer therapy; the plant kingdom provides an important source of molecules. Conofolidine is a novel Aspidosperma-Aspidosperma bisindole alkaloid isolated from the Malayan plant Tabernaemontana corymbosa ...
Mohammed Zuhair Al-Hayali +5 more
doaj +2 more sources
Molecules, 2022 N-Protected 3-iodoindoles were reacted with (di)azine halides in a sequentially Pd-catalyzed one-pot fashion, i.e., by Masuda borylation–Suzuki coupling (MBSC) sequence.
Marco Kruppa +2 more
doaj +1 more source
Synthesis and biological activity of bisindole derivatives as novel MARK4 inhibitors
European Journal of Medicinal Chemistry Reports, 2022 Bisindole alkaloids are well-known bioactive natural products presenting numerous pharmacological properties. Following the indolocarbazole biosynthetic pathway a series of bisindole derivatives were synthesized and their activity against MARK4 kinase ...
Maria Voura +7 more
doaj +1 more source