Results 11 to 20 of about 1,599 (196)

Combined Transcriptomic and Metabolomic Analysis Reveals an Ethylene-Activated Regulatory Model on Monoterpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus. [PDF]

Plant Biotechnol J
ABSTRACT Catharanthus roseus contains nearly 200 bioactive monoterpenoid indole alkaloids (MIAs) that are effective in treating cancer and other diseases. Ethylene plays a significant role in enhancing MIA biosynthesis, and we have found that it greatly induces the accumulation of anhydrovinblastine.
Deng B, Miao Q, Ou C, Pan Y, Liu H, Fu X, Li L, Wang Y, Tang K, Pan Q.   +9 more
europepmc   +2 more sources

Oxidative Rearrangements of the Alkaloid Intermediate Geissoschizine. [PDF]

Angew Chem Int Ed Engl
19E‐geissoschizine is a key precursor in the biosynthesis of monoterpene indole alkaloids such as strychnine, ibogaine, and vinblastine. Using enzymatic assays and gene silencing, three CYPs were identified from C. roseus that oxidize this compound to four alkaloid scaffolds: strychnos, sarpagan, akuammiline, and mavacurane. Mutational analysis reveals
Kamileen MO, Hong B, Gase K, Kunert M, Caputi L, Lichman BR, O'Connor SE.   +6 more
europepmc   +3 more sources

One-Pot Synthesis of Novel β-Carboline-{α-Acylaminoamide}-Bisindole Derivatives: Antibacterial Evaluation, Molecular Docking, and Density Functional Theory Studies. [PDF]

ChemistryOpen
A new series of β‐carboline‐{α‐acylaminoamide}‐bisindole hybrids (12a–l) employing an atom‐economical one‐pot Ugi four‐component reaction and their antibacterial testing alongside docking studies, is reported. A new series of β‐carboline‐{α‐acylaminoamide}‐bisindole hybrids (12a–l) is designed and synthesized employing an atom‐economical one‐pot Ugi ...
Atri AK, Khullar L, Kumar G, Mishra S, Dua T, Singh V, Harjai K, Singh P, Singh V.   +8 more
europepmc   +2 more sources

Concise Syntheses of Marine (Bis)indole Alkaloids Meridianin C, D, F, and G and Scalaridine A via One-Pot Masuda Borylation-Suzuki Coupling Sequence

Molecules, 2022
N-Protected 3-iodoindoles were reacted with (di)azine halides in a sequentially Pd-catalyzed one-pot fashion, i.e., by Masuda borylation–Suzuki coupling (MBSC) sequence.
Marco Kruppa, Gereon A. Sommer, Thomas J. J. Müller   +2 more
doaj   +1 more source

Bisindole alkaloids from Voacanga grandifolia leaves

Journal of Natural Medicines, 2021
Two new bisindole alkaloids, 12'-O-demethyl-vobtusine-5-lactam and isovobtusine-N-oxide (1 and 2), were isolated from the leaves of Voacanga grandifolia, together with two known bisindole alkaloids. Their structures were elucidated on the basis of 1D and 2D NMR data. 1 and 2 showed potent antimalarial activity against Plasmodium falciparum 3D7 and very
Alfarius Eko Nugroho, -, Yurika Ono, -, Eunji Jin, -, Yusuke Hirasawa, -, Toshio Kaneda, -, Abdul Rahman, -, Idha Kusumawati, -, Takahiro Tougan, -, Toshihiro Horii, -, Noor Cholies Zaini, -, Hiroshi Morita, -   +10 more
openaire   +3 more sources

Discovery of Barakacin and Its Derivatives as Novel Antiviral and Fungicidal Agents

Molecules, 2023
Pesticides are essential for the development of agriculture. It is urgent to develop green, safe and efficient pesticides. Bisindole alkaloids have unique and concise structures and broad biological activities, which make them an important leading ...
Yongyue Gao, Xingxing He, Lili Yan, Hongyu Zhang, Sijia Liu, Qian Ma, Peiyao Zhang, Yan Zhang, Zijun Zhang, Ziwen Wang, Aidang Lu, Qingmin Wang   +11 more
doaj   +1 more source

Synthesis and biological activity of bisindole derivatives as novel MARK4 inhibitors

European Journal of Medicinal Chemistry Reports, 2022
Bisindole alkaloids are well-known bioactive natural products presenting numerous pharmacological properties. Following the indolocarbazole biosynthetic pathway a series of bisindole derivatives were synthesized and their activity against MARK4 kinase ...
Maria Voura, Saleha Anwar, Savvas Thysiadis, Parvez Κhan, Panagiotis Dalezis, Dimitrios T. Trafalis, Md Imtaiyaz Hassan, Vasiliki Sarli   +7 more
doaj   +1 more source

Enantioselective Strategies for The Synthesis of N−N Atropisomers

Angewandte Chemie, Volume 135, Issue 31, August 1, 2023., 2023
Recent advances in the enantioselective synthesis of N−N atropisomers are highlighted and discussed within this Review. In particular, the strategies and breakthroughs to obtain this novel and stimulating atropisomeric architecture are presented while a particular attention is given to mechanistic aspects.
Giovanni Centonze, Chiara Portolani, Paolo Righi, Giorgio Bencivenni   +3 more
wiley   +2 more sources

Eight Indole Alkaloids from the Roots of Maerua siamensis and Their Nitric Oxide Inhibitory Effects

Molecules, 2022
Maerua siamensis (Capparaceae) roots are used for treating pain and inflammation in traditional Thai medicine. Eight new indole alkaloids, named maeruanitriles A and B, maeroximes A–C, and maeruabisindoles A–C, were isolated from them.
Sasiwimon Nukulkit, Angkana Jantimaporn, Preeyaporn Poldorn, Mattaka Khongkow, Thanyada Rungrotmongkol, Hsun-Shuo Chang, Rutt Suttisri, Chaisak Chansriniyom   +7 more
doaj   +1 more source

Bioactive Bis(indole) Alkaloids from a Spongosorites sp. Sponge

Marine Drugs, 2020
Six new bis(indole) alkaloids (1–6) along with eight known ones of the topsentin class were isolated from a Spongosorites sp. sponge of Korea. Based on the results of combined spectroscopic analyses, the structures of spongosoritins A–D (1–4) were ...
Jae Sung Park, Eunji Cho, Ji-Yeon Hwang, Sung Chul Park, Beomkoo Chung, Oh-Seok Kwon, Chung J. Sim, Dong-Chan Oh, Ki-Bong Oh, Jongheon Shin   +9 more
doaj   +1 more source