Results 11 to 20 of about 954 (177)

Synthesis of Bisindole Alkaloids from the Apocynaceae Which Contain a Macroline or Sarpagine Unit: A Review [PDF]

Molecules, 2016
Bisindole natural products consist of two monomeric indole alkaloid units as their obligate constituents. Bisindoles are more potent with respect to their biological activity than their corresponding monomeric units.
Md Toufiqur Rahman, Veera V. N. Phani Babu Tiruveedhula, James M. Cook   +2 more
doaj   +6 more sources

CrERF5, an AP2/ERF Transcription Factor, Positively Regulates the Biosynthesis of Bisindole Alkaloids and Their Precursors in Catharanthus roseus [PDF]

Frontiers in Plant Science, 2019
Catharanthus roseus contains a variety of monoterpenoid indole alkaloids (MIAs), among which bisindole alkaloids vinblastine and vincristine are well-known to have antitumor effects and widely used in clinical treatment.
Qifang Pan, Chenyi Wang, Zhiwei Xiong, Hang Wang, Xueqing Fu, Qian Shen, Bowen Peng, Yanan Ma, Xiaofen Sun, Kexuan Tang   +9 more
doaj   +4 more sources

Brominated Bisindole Alkaloids from the Celtic Sea Sponge Spongosorites calcicola [PDF]

Molecules, 2019
As part of an ongoing program to identify new bioactive compounds from Irish marine bioresources, we selected the subtidal sponge Spongosorites calcicola for chemical study, as fractions of this species displayed interesting cytotoxic bioactivities and ...
Laurence K. Jennings, Neyaz M. D. Khan, Navdeep Kaur, Daniel Rodrigues, Christine Morrow, Aoife Boyd, Olivier P. Thomas   +6 more
doaj   +3 more sources

Aspidospermatan–aspidospermatan and eburnane-sarpagine bisindole alkaloids from Leuconotis

Phytochemistry, 2010
Leucofoline and leuconoline, representing the first members of the aspidospermatan–aspidospermatan and eburnane-sarpagine subclasses of the bisindole alkaloids, respectively, were isolated from the Malayan Leuconotis griffithii.
Yun-Yee Low, Toh-Seok Kam
exaly   +6 more sources

Bisindole Alkaloids from the Alstonia Species: Recent Isolation, Bioactivity, Biosynthesis, and Synthesis [PDF]

Molecules, 2021
Bisindoles are structurally complex dimers and are intriguing targets for partial and total synthesis. They exhibit stronger biological activity than their corresponding monomeric units.
Kamal P. Pandey, Md Toufiqur Rahman, James M. Cook   +2 more
doaj   +2 more sources

Bisindole alkaloids from Voacanga grandifolia leaves [PDF]

Journal of Natural Medicines, 2021
Two new bisindole alkaloids, 12′-O-demethyl-vobtusine-5-lactam and isovobtusine-N-oxide (1 and 2), were isolated from the leaves of Voacanga grandifolia, together with two known bisindole alkaloids. Their structures were elucidated on the basis of 1D and
Eunji Jin, -, Yusuke Hirasawa, -, Toshihiro Horii, -, Alfarius Eko Nugroho, -, Toshio Kaneda, -, Abdul Rahman, -, Yurika Ono, -, Idha Kusumawati, -, Noor Cholies Zaini, -, Takahiro Tougan, -, Hiroshi Morita, -   +10 more
core   +4 more sources

Combined Transcriptomic and Metabolomic Analysis Reveals an Ethylene-Activated Regulatory Model on Monoterpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus. [PDF]

Plant Biotechnol J
ABSTRACT Catharanthus roseus contains nearly 200 bioactive monoterpenoid indole alkaloids (MIAs) that are effective in treating cancer and other diseases. Ethylene plays a significant role in enhancing MIA biosynthesis, and we have found that it greatly induces the accumulation of anhydrovinblastine.
Deng B, Miao Q, Ou C, Pan Y, Liu H, Fu X, Li L, Wang Y, Tang K, Pan Q.   +9 more
europepmc   +2 more sources

Oxidative Rearrangements of the Alkaloid Intermediate Geissoschizine. [PDF]

Angew Chem Int Ed Engl
19E‐geissoschizine is a key precursor in the biosynthesis of monoterpene indole alkaloids such as strychnine, ibogaine, and vinblastine. Using enzymatic assays and gene silencing, three CYPs were identified from C. roseus that oxidize this compound to four alkaloid scaffolds: strychnos, sarpagan, akuammiline, and mavacurane. Mutational analysis reveals
Kamileen MO, Hong B, Gase K, Kunert M, Caputi L, Lichman BR, O'Connor SE.   +6 more
europepmc   +3 more sources

One-Pot Synthesis of Novel β-Carboline-{α-Acylaminoamide}-Bisindole Derivatives: Antibacterial Evaluation, Molecular Docking, and Density Functional Theory Studies. [PDF]

ChemistryOpen
A new series of β‐carboline‐{α‐acylaminoamide}‐bisindole hybrids (12a–l) employing an atom‐economical one‐pot Ugi four‐component reaction and their antibacterial testing alongside docking studies, is reported. A new series of β‐carboline‐{α‐acylaminoamide}‐bisindole hybrids (12a–l) is designed and synthesized employing an atom‐economical one‐pot Ugi ...
Atri AK, Khullar L, Kumar G, Mishra S, Dua T, Singh V, Harjai K, Singh P, Singh V.   +8 more
europepmc   +2 more sources

Bisindole alkaloids

, 2006
This chapter provides an overview on bisindole alkaloids. The indole–indole and tryptamine–tryptamine type, and related alkaloids are discussed. Tryptamine–tryptamine type with an additional monoterpene unit and related alkaloids are briefly discussed ...
Toh-Seok Kam, Choo, Yeun Mun, Kam, Toh Seok, Yeun-Mun Choo   +3 more
core   +2 more sources