Results 41 to 50 of about 70,439 (171)
MoleculesSynthetic efforts toward complex natural product (NP) scaffolds are useful ones, particularly those aimed at expanding their bioactive chemical space.
Darren C. Holland +3 more
doaj +1 more source
ChemistryOpen, Volume 14, Issue 11, November 2025.Arenaria serpyllifolia extract exhibits strong antioxidant, antimicrobial, antibiofilm, and antiquorum sensing activities. Key compounds, including levoglucosan and guanosine, show potent CviR receptor binding. Violacein inhibition and molecular dynamics confirm their stability, highlighting their potential as quorum sensing inhibitors and therapeutic ...
Meryem Burcu Külahcı +5 more
wiley +1 more source
Indole and bisindole alkaloids from Tabernaemontana corymbosa / Nge Choy Eng [PDF]
, 2017 A total of 59 alkaloids (1−59) were isolated and characterized from the leaf and stem-bark extracts of the Malayan Tabernaemontana corymbosa Roxb. ex Wall.. Of these, 25 are new alkaloids.
Nge, Choy Eng
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Chemistry – A European Journal, Volume 31, Issue 43, August 1, 2025.A library of novel bisindole derivatives was synthesized through an optimized rapid Suzuki‐Miyaura coupling reaction, utilizing NH2‐unprotected bromobisindole ethanamines and boronic acids with yields up to 93%. The compounds were screened for their activity against L. infantum promastigotes.
Alessandro Buono +8 more
wiley +1 more source
Chapter 3 Noniridoid Bisindole Alkaloids
, 1995 This chapter discusses that indole is a reactive nucleus prone to dimerization when it is isolated or a part of tryptamine or tryptophan, which themselves are reactive toward many functionalities. For these reasons, bisindoles, the majority of which are of iridoid origin, are frequently isolated in nature. Besides these “dimers,” there exists a growing
Sapi, J., Massiot, G.
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Synthesis of Marine Sponge Bisindole Alkaloids Dihydrohamacanthins
, 2016 A convergent synthesis of the marine sponge bisindole alkaloids dihydrohamacanthins is described. The synthesis centers on the construction of 3,5- and 3,6-linked pyrazinones and their reduction to the requisite piperazinones with sodium ...
Fumiko Y. Miyake (2702866) +2 more
core +1 more source
From data to discovery: leveraging big data in plant natural products biosynthesis research
The Plant Journal, Volume 122, Issue 6, June 2025.SUMMARY Plant natural products or specialized metabolites play a vital role in drug discovery and development, with many clinically important derivatives such as the anticancer drugs topotecan (derived from the natural alkaloid camptothecin) and etoposide (derived from the natural polyphenol podophyllotoxin).
Matthew McConnachie +4 more
wiley +1 more source
Food Science &Nutrition, Volume 12, Issue 12, Page 9951-9973, December 2024.This study discussed the therapeutic capacity of various polyphenols, terpenoids, and alkaloids on CRC via the PI3K/Akt/mTOR pathway. Each bioactive component causes various physiological processes, such as triggering free radical production, disruption of mitochondrial membrane potential, cell cycle arrest, inhibition of CRC stem cell migration ...
Kübra Demir +4 more
wiley +1 more source
Conofolidine: A Natural Plant Alkaloid That Causes Apoptosis and Senescence in Cancer Cells
MoleculesNatural products contribute substantially to anticancer therapy; the plant kingdom provides an important source of molecules. Conofolidine is a novel Aspidosperma-Aspidosperma bisindole alkaloid isolated from the Malayan plant Tabernaemontana corymbosa ...
Mohammed Zuhair Al-Hayali +5 more
doaj +1 more source
First De Novo Synthesis of the Bisindole Alkaloid Vinblastine.
ChemInform, 2002 AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire +4 more sources