Results 61 to 70 of about 1,599 (196)
Transcription Factors in Alkaloid Engineering [PDF]
, 2021 Plants produce a large variety of low-molecular-weight and specialized secondary compounds. Among them, nitrogen-containing alkaloids are the most biologically active and are often used in the pharmaceutical industry. Although alkaloid chemistry has been
Sato, Fumihiko, Yamada, Yasuyuki
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ChemistryOpen, Volume 14, Issue 11, November 2025.Arenaria serpyllifolia extract exhibits strong antioxidant, antimicrobial, antibiofilm, and antiquorum sensing activities. Key compounds, including levoglucosan and guanosine, show potent CviR receptor binding. Violacein inhibition and molecular dynamics confirm their stability, highlighting their potential as quorum sensing inhibitors and therapeutic ...
Meryem Burcu Külahcı +5 more
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MoleculesSynthetic efforts toward complex natural product (NP) scaffolds are useful ones, particularly those aimed at expanding their bioactive chemical space.
Darren C. Holland +3 more
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Chemistry – A European Journal, Volume 31, Issue 43, August 1, 2025.A library of novel bisindole derivatives was synthesized through an optimized rapid Suzuki‐Miyaura coupling reaction, utilizing NH2‐unprotected bromobisindole ethanamines and boronic acids with yields up to 93%. The compounds were screened for their activity against L. infantum promastigotes.
Alessandro Buono +8 more
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Phytochemical and Pharmacological Properties of the Genus Melodinus – A Review [PDF]
, 2016 Melodinus is an important genus comprising of approximately 53 species of medicinal plants (Apocynaceae). Some species have been used in Chinese folk medicine for the treatment of meningitis in children, rheumatic heart diseases, and diuresis, as well as
Chen, Ye-Gao +2 more
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Cyclopropanation of Some Alkaloids [PDF]
, 2015 New derivatives of natural compounds, galanthamine using in treatment of Alzheimer’s disease and antitumor dimer alkaloids vinblastine and vincristine were synthesized.
Hazai, László +3 more
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From data to discovery: leveraging big data in plant natural products biosynthesis research
The Plant Journal, Volume 122, Issue 6, June 2025.SUMMARY Plant natural products or specialized metabolites play a vital role in drug discovery and development, with many clinically important derivatives such as the anticancer drugs topotecan (derived from the natural alkaloid camptothecin) and etoposide (derived from the natural polyphenol podophyllotoxin).
Matthew McConnachie +4 more
wiley +1 more source
Food Science &Nutrition, Volume 12, Issue 12, Page 9951-9973, December 2024.This study discussed the therapeutic capacity of various polyphenols, terpenoids, and alkaloids on CRC via the PI3K/Akt/mTOR pathway. Each bioactive component causes various physiological processes, such as triggering free radical production, disruption of mitochondrial membrane potential, cell cycle arrest, inhibition of CRC stem cell migration ...
Kübra Demir +4 more
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Plant-derived antimalarial agents: from crude extracts to isolated bioactive compounds [PDF]
, 2011 Despite decades of intense research, malaria remains a deadly disease of the developing worlds. Drugresistance to limited available antimalarials, in part, has contributed to the persistence of this infectious disease.
Abdullah, Wan Omar, Ismail, Patimah
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Phosphorus-sulfur heterocycles incorporating an O-P(S)-O or O-P(S)-S-S-P(S)-O scaffold : one-pot synthesis and crystal structure study [PDF]
, 2017 The authors are grateful to the University of St Andrews for financial support.A new one-pot preparative route was developed to synthesize novel organophosphorus sulfur heterocycles via the reaction of the four-membered ring thionation reagent [2,4 ...
Cordes, David B. +5 more
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