Results 61 to 70 of about 954 (177)
Angustifonines A and B, Cytotoxic Bisindole Alkaloids from Bousigonia angustifolia
, 2016 Two new bisindole alkaloids, angustifonines A (1) and B (2), comprising the union of a rearranged monoterpenoid quinoline and an aspidospermine alkaloid, as well as 27 known indole alkaloids were isolated from the twigs and leaves of Bousigonia ...
Yu Zhang (12946) +5 more
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Chapter 3 Noniridoid Bisindole Alkaloids
, 1995 This chapter discusses that indole is a reactive nucleus prone to dimerization when it is isolated or a part of tryptamine or tryptophan, which themselves are reactive toward many functionalities. For these reasons, bisindoles, the majority of which are of iridoid origin, are frequently isolated in nature. Besides these “dimers,” there exists a growing
Sapi, J., Massiot, G.
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, 2019 Catharanthus roseus contains a variety of monoterpenoid indole alkaloids (MIAs), among which bisindole alkaloids vinblastine and vincristine are well-known to have antitumor effects and widely used in clinical treatment.
Hang Wang (137566) +9 more
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From data to discovery: leveraging big data in plant natural products biosynthesis research
The Plant Journal, Volume 122, Issue 6, June 2025.SUMMARY Plant natural products or specialized metabolites play a vital role in drug discovery and development, with many clinically important derivatives such as the anticancer drugs topotecan (derived from the natural alkaloid camptothecin) and etoposide (derived from the natural polyphenol podophyllotoxin).
Matthew McConnachie +4 more
wiley +1 more source
Macroline–Sarpagine Bisindole Alkaloids with Antiproliferative Activity from Alstonia penangiana
, 2019 A methanol extract of the stem bark of the Malayan Alstonia penangiana provided seven new bisindole alkaloids, comprising six macroline–sarpagine alkaloids (angustilongines E–K, 1–6) and one macroline–pleiocarpamine bisindole alkaloid (angustilongine L ...
Yun-Yee Low +13 more
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Food Science &Nutrition, Volume 12, Issue 12, Page 9951-9973, December 2024.This study discussed the therapeutic capacity of various polyphenols, terpenoids, and alkaloids on CRC via the PI3K/Akt/mTOR pathway. Each bioactive component causes various physiological processes, such as triggering free radical production, disruption of mitochondrial membrane potential, cell cycle arrest, inhibition of CRC stem cell migration ...
Kübra Demir +4 more
wiley +1 more source
First De Novo Synthesis of the Bisindole Alkaloid Vinblastine.
ChemInform, 2002 AbstractFor Abstract see ChemInform Abstract in Full Text.
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Cytotoxic Bisindole Alkaloids from a Marine Sponge Spongosorites sp.
, 2016 Three new bisindole alkaloids of the hamacanthin class (1−3) and one new bisindole alkaloid of the topsentin class (6) were isolated along with known bisindole alkaloids (4, 5, 7−11) from the MeOH extract of a marine sponge Spongosorites sp.
Qishi Sun (2681866) +7 more
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Mechanochemistry in Organic Synthesis: An Italian Journey through Innovations
European Journal of Organic Chemistry, Volume 27, Issue 30, August 12, 2024.The contribution of Italy to the development of mechanochemistry dates back to 1988 with the first studies on metal alloys. With the progress of time, it has flourished not only in the field of organic chemistry, but also in other scientific fields due to the enormous interest of Italian researchers in the various advantages brought by this technique ...
Francesco Basoccu +2 more
wiley +1 more source
Ajmaline, Oxindole, and Cytotoxic Macroline–Akuammiline Bisindole Alkaloids from Alstonia penangiana
, 2018 Examination of the EtOH extract of the Malayan Alstonia penangiana resulted in the isolation of 10 new alkaloids, comprising two ajmaline (1, 2), four macroline oxindole (3-6), and four macroline-akuammiline bisindole alkaloids (7-10).
Yong, Kien Thai +15 more
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