Results 51 to 60 of about 1,599 (196)

Antibacterial activities of selected edible plants extracts against multidrug-resistant Gram-negative bacteria [PDF]

open access: yes, 2013
BACKGROUND: In response to the propagation of bacteria resistant to many antibiotics also called multi-drug resistant (MDR) bacteria, the discovery of new and more efficient antibacterial agents is primordial.
Aimé G Fankam   +7 more
core   +1 more source

Chapter 3 Noniridoid Bisindole Alkaloids

open access: yes, 1995
This chapter discusses that indole is a reactive nucleus prone to dimerization when it is isolated or a part of tryptamine or tryptophan, which themselves are reactive toward many functionalities. For these reasons, bisindoles, the majority of which are of iridoid origin, are frequently isolated in nature. Besides these “dimers,” there exists a growing
Sapi, J., Massiot, G.
openaire   +1 more source

2,3‐Dichloro‐5,6‐Dicyano‐1,4‐Benzoquinone (DDQ)‐Mediated CC Bond Formation: Redox Strategies from Stoichiometric to Catalytic Systems

open access: yesChemistryOpen, Volume 15, Issue 4, April 2026.
2,3‐Dichloro‐5,6‐dicyano‐1,4‐benzoquinone serves as a versatile oxidant and redox catalyst for CC bond formation through hydride abstraction or single‐electron transfer. Stoichiometric and catalytic systems enable benzylic, allylic, and aromatic CH activation under mild, metal‐free conditions, providing sustainable routes to complex and bioactive ...
Dohoon Cha, Sun‐Joon Min
wiley   +1 more source

Natural products as novel scaffolds for the design of glycogen synthase kinase 3β inhibitors [PDF]

open access: yes, 2022
Introduction: The different and relevant roles of GSK-3 are of critical importance since they deal with development, metabolic homeostasis, cell polarity and fate, neuronal growth and differentiation as well as modulation of apoptotic potential.
Andrisano V.   +7 more
core   +1 more source

The Raputindoles: Novel Cyclopentyl Bisindole Alkaloids from Raputia simulans

open access: yesOrganic Letters, 2010
A novel class of bisindole alkaloids is established by the isolation and structural determination of raputindoles A-D (1-4) from the Amazonian plant Raputia simulans Kallunki (Rutaceae). Complete spectroscopic characterization was accomplished by means of NMR spectroscopy and APCI (+) HRMS.
Vougogiannopoulou, K.   +4 more
openaire   +3 more sources

Marine indole alkaloids [PDF]

open access: yes, 2015
Marine indole alkaloids comprise a large and steadily growing group of secondary metabolites. Their diverse biological activities make many compounds of this class attractive starting points for pharmaceutical development.
Netz, Natalie, Opatz, Till
core   +1 more source

Isolation and structural elucidation of compounds from Pleiocarpa bicarpellata and their in vitro antiprotozoal activity [PDF]

open access: yes, 2022
Species of the genus Pleiocarpa are used in traditional medicine against fever and malaria. The present study focuses on the isolation and identification of bioactive compounds from P.
Bella, M. A.   +7 more
core   +1 more source

Ligand‐Based Pharmacophore Mapping and Virtual Screening for the Search of Biguanide‐Like Molecules With Antidiabetic Potentials Targeting Liver Kinase B1

open access: yesBiochemistry Research International, Volume 2026, Issue 1, 2026.
Type 2 diabetes mellitus (T2DM) is a state where the body’s glucose metabolism is compromised. AMP‐activated protein kinase, or AMPK, has an important part to play in glucose metabolism, and the liver kinase B1 (LKB1) protein functions as a major upstream kinase for AMPK activation, thereby making it appealing therapeutic targets for treating and ...
Rumman Reza   +6 more
wiley   +1 more source

Stereoselective Synthesis of 2-(2-Aminoalkyl)- and 1,3-Disubstituted Tetrahydro-1H-pyrido[4,3-b]- Benzofuran and Indole Derivatives [PDF]

open access: yes, 2016
The addition of an allenyl indium intermediate to chiral N-tert-butanesulfinyl imines 7 proceeds with high levels of diastereocontrol. The resulting homopropargylic amine derivatives 10 were transformed into 2-(2-aminoalkyl)benzofuran and indole ...
Foubelo, Francisco   +2 more
core   +3 more sources

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