Results 21 to 30 of about 954 (177)

Marine-Derived Bisindoles for Potent Selective Cancer Drug Discovery and Development [PDF]

Molecules
Marine-derived bisindoles exhibit structural diversity and exert anti-cancer influence through multiple mechanisms. Comprehensive research has shown that the development success rate of drugs derived from marine natural products is four times higher than
Mengwei Xu, Zhaofang Bai, Baocheng Xie, Rui Peng, Ziwei Du, Yan Liu, Guangshuai Zhang, Si Yan, Xiaohe Xiao, Shuanglin Qin   +9 more
doaj   +2 more sources

Globospiramine from Voacanga globosa Exerts Robust Cytotoxic and Antiproliferative Activities on Cancer Cells by Inducing Caspase-Dependent Apoptosis in A549 Cells and Inhibiting MAPK14 (p38α): In Vitro and Computational Investigations [PDF]

Cells
Bisindole alkaloids are a source of inspiration for the design and discovery of new-generation anticancer agents. In this study, we investigated the cytotoxic and antiproliferative activities of three spirobisindole alkaloids from the traditional ...
Joe Anthony H. Manzano, Elian Angelo Abellanosa, Jose Paolo Aguilar, Simone Brogi, Chia-Hung Yen, Allan Patrick G. Macabeo, Nicanor Austriaco   +6 more
doaj   +2 more sources

Biologically active indole and bisindole alkaloids from Tabernaemontana divaricata

Organic & Biomolecular Chemistry, 2003
The ethanol extract of the leaves of Tabernaemontana divaricata (double flower variety) provided a total of 23 alkaloids, including the new aspidosperma alkaloids, taberhanine, voafinine, N-methylvoafinine, voafinidine, voalenine and the new bisindole ...
Lim, Tuck-Meng, Tuck‐Meng Lim, Huey‐Shen Pang, Kam, Toh-Seok, Pang, Huey-Shen, Toh‐Seok Kam   +5 more
core   +4 more sources

Conofolidine: A Natural Plant Alkaloid That Causes Apoptosis and Senescence in Cancer Cells [PDF]

Molecules
Natural products contribute substantially to anticancer therapy; the plant kingdom provides an important source of molecules. Conofolidine is a novel Aspidosperma-Aspidosperma bisindole alkaloid isolated from the Malayan plant Tabernaemontana corymbosa ...
Mohammed Zuhair Al-Hayali, Choy-Eng Nge, Kuan Hon Lim, Hilary M. Collins, Toh-Seok Kam, Tracey D. Bradshaw   +5 more
doaj   +2 more sources

Leucophyllinines A and B, bisindole alkaloids from Leuconotis eugeniifolia

Journal of Natural Medicines, 2019
Two new bisindole alkaloids, leucophyllinines A (1) and B (2) consisting of eburnane and quebrachamine-type skeletons were isolated from the bark of Leuconotis eugeniifolia, and their structures were elucidated on the basis of spectroscopic data ...
Horii, Toshihiro, Tang, Yiming, Hirasawa, Yusuke, Nugroho, Alfarius Eko, Hadi, A. Hamid A., Morita, Hiroshi, Tougan, Takahiro   +6 more
core   +4 more sources

Angustilobine and andranginine type indole alkaloids and an uleine–secovallesamine bisindole alkaloid from Alstonia angustiloba

Phytochemistry, 2011
A total of 20 alkaloids were isolated from the leaf and stem-bark extracts of Alstonia angustiloba, of which two are hitherto unknown. One is an alkaloid of the angustilobine type (angustilobine C), while the other is a bisindole alkaloid angustiphylline,
Shin-Jowl Tan, Yun-Yee Low, Toh-Seok Kam   +2 more
exaly   +2 more sources

Two new bisindole alkaloids from Tabernaemontana macrocarpa Jack. [PDF]

J Nat Med, 2021
Two new bisindole alkaloids, bisnaecarpamines A (1) and B (2), possessing a vobasine-sarpagine type skeleton were isolated from the bark of Tabernaemontana macrocarpa Jack. Their structures were elucidated by extensive spectroscopic methods and chemical correlation.
Amelia P, Nugroho AE, Hirasawa Y, Kaneda T, Tougan T, Horii T, Morita H.   +6 more
europepmc   +4 more sources

Concise Syntheses of Marine (Bis)indole Alkaloids Meridianin C, D, F, and G and Scalaridine A via One-Pot Masuda Borylation-Suzuki Coupling Sequence

Molecules, 2022
N-Protected 3-iodoindoles were reacted with (di)azine halides in a sequentially Pd-catalyzed one-pot fashion, i.e., by Masuda borylation–Suzuki coupling (MBSC) sequence.
Marco Kruppa, Gereon A. Sommer, Thomas J. J. Müller   +2 more
doaj   +1 more source

Discovery of Barakacin and Its Derivatives as Novel Antiviral and Fungicidal Agents

Molecules, 2023
Pesticides are essential for the development of agriculture. It is urgent to develop green, safe and efficient pesticides. Bisindole alkaloids have unique and concise structures and broad biological activities, which make them an important leading ...
Yongyue Gao, Xingxing He, Lili Yan, Hongyu Zhang, Sijia Liu, Qian Ma, Peiyao Zhang, Yan Zhang, Zijun Zhang, Ziwen Wang, Aidang Lu, Qingmin Wang   +11 more
doaj   +1 more source

Synthesis and biological activity of bisindole derivatives as novel MARK4 inhibitors

European Journal of Medicinal Chemistry Reports, 2022
Bisindole alkaloids are well-known bioactive natural products presenting numerous pharmacological properties. Following the indolocarbazole biosynthetic pathway a series of bisindole derivatives were synthesized and their activity against MARK4 kinase ...
Maria Voura, Saleha Anwar, Savvas Thysiadis, Parvez Κhan, Panagiotis Dalezis, Dimitrios T. Trafalis, Md Imtaiyaz Hassan, Vasiliki Sarli   +7 more
doaj   +1 more source