Results 61 to 70 of about 2,045 (191)
Protein & Cell, 2018 Lysosomes are degradation and signaling centers within the cell, and their dysfunction impairs a wide variety of cellular processes. To understand the cellular effect of lysosome damage, we screened natural small-molecule compounds that induce lysosomal ...
Yang Li +13 more
doaj +1 more source
Food Science &Nutrition, Volume 12, Issue 12, Page 9951-9973, December 2024.This study discussed the therapeutic capacity of various polyphenols, terpenoids, and alkaloids on CRC via the PI3K/Akt/mTOR pathway. Each bioactive component causes various physiological processes, such as triggering free radical production, disruption of mitochondrial membrane potential, cell cycle arrest, inhibition of CRC stem cell migration ...
Kübra Demir +4 more
wiley +1 more source
A Facile Synthesis of Deaza-Analogues of the Bisindole Marine Alkaloid Topsentin
Molecules, 2013 A series of substituted ethyl 1-[(tert-butoxycarbonyl)amino]-2-methyl-5- (1-methyl-1H-indol-3-yl)-4-[(1-methyl-1H-indol-3-yl)carbonyl]-1H-pyrrole-3-carboxylates were prepared in excellent yields (82-98%) by one-pot reactions between β-dicarbonyl ...
Gianfranco Favi +5 more
doaj +1 more source
Biosynthesis of Arcyriaflavin F from Streptomyces venezuelae ATCC 10712
ChemBioChem, Volume 25, Issue 20, October 16, 2024.We report the characterisation of the Streptomyces venezuelae ATCC 10712 arcyriaflavin F biosynthetic gene cluster. We express the gene cluster using Streptomyces coelicolor M1152 as a heterologous host, isolate the product and confirm distinct C‐5/C‐5’ indole ring hydroxylation catalysed by a regioselective flavoprotein AcfX. Abstract Indolocarbazoles
Hung‐En Lai +6 more
wiley +1 more source
The Raputindoles: Novel Cyclopentyl Bisindole Alkaloids from Raputia simulans
Organic Letters, 2010 A novel class of bisindole alkaloids is established by the isolation and structural determination of raputindoles A-D (1-4) from the Amazonian plant Raputia simulans Kallunki (Rutaceae). Complete spectroscopic characterization was accomplished by means of NMR spectroscopy and APCI (+) HRMS.
Vougogiannopoulou, K. +4 more
openaire +3 more sources
Bis-indole chiral architectures for asymmetric catalysis
Nature CommunicationsChiral scaffolds are essential to the advancement of asymmetric synthesis, yet the development of privileged motifs that more effectively communicate asymmetry constitutes a grand challenge for chemists.
Junshan Lai +2 more
doaj +1 more source
A Simple Strategy for Obtaining Bis-Indole Derivatives under Solvent Free Conditions [PDF]
Journal of Chemistry LettersBis-indole, a biomolecule which has acquired its own place in heterocyclic chemistry because of remarkable biological properties.These derivatives can be synthesized by the reaction of indole having carbonyl compound like aldehydes and ketones in the ...
Praveen Mugali +4 more
doaj +1 more source
Attempted Synthesis of Vinca Alkaloids Condensed with Three-Membered Rings
Molecules, 2018 Our successful work for the synthesis of cyclopropanated vinblastine and its derivatives by the Simmons–Smith reaction was followed to build up further three-membered rings into the 14,15-position of the vindoline part of the dimer alkaloid ...
András Keglevich +8 more
doaj +1 more source
Molecules, 2017 Indirubin is an active component of the herbal ingredient ‘Danggui Longhui wan’, which was used for the treatment of inflammation and chronic myeloid leukemia in China.
Jana Tegethoff +5 more
doaj +1 more source
Molecules, 2007 Dried leaves of Catharanthus roseus were extracted with aqueous acidic 0.1 M solution of HCl. Alkaloid-embonate complexes were obtained as precipitates by treating the extract with an alkaline (NaOH) solution of embonic acid (4,4-methylene-bis-3 ...
Marja-Liisa Riekkola +4 more
doaj +1 more source