Results 61 to 70 of about 1,592 (193)
CHIMIA, 2014 Trigonoliimines are hexacyclic bisindole alkaloids isolated recently by Hao and co-workers. A synthesis of (±)-trigonoliimine B was accomplished in seven steps from simple starting materials featuring the Bischler-Napieralski reaction for ...
Thomas Buyck, Qian Wang, Jieping Zhu
doaj +1 more source
Analytical Cellular Pathology, Volume 2026, Issue 1, 2026.Naegleria fowleri, the brain‐eating ameba, causes primary amebic meningoencephalitis (PAM), a fatal infectious disease that affects the central nervous system (CNS). We aimed to evaluate the functions and potential drugs targeting PAM using text mining and bioinformatics analyses.
Eun Jung Sohn +3 more
wiley +1 more source
Molecules, 2021 Bisindoles are structurally complex dimers and are intriguing targets for partial and total synthesis. They exhibit stronger biological activity than their corresponding monomeric units.
Kamal P. Pandey +2 more
doaj +1 more source
Biochemistry Research International, Volume 2026, Issue 1, 2026.Type 2 diabetes mellitus (T2DM) is a state where the body’s glucose metabolism is compromised. AMP‐activated protein kinase, or AMPK, has an important part to play in glucose metabolism, and the liver kinase B1 (LKB1) protein functions as a major upstream kinase for AMPK activation, thereby making it appealing therapeutic targets for treating and ...
Rumman Reza +6 more
wiley +1 more source
Macroline–Sarpagine Bisindole Alkaloids with Antiproliferative Activity from Alstonia penangiana
, 2019 A methanol extract of the stem bark of the Malayan Alstonia penangiana provided seven new bisindole alkaloids, comprising six macroline-sarpagine alkaloids (angustilongines E-K, 1-6) and one macroline-pleiocarpamine bisindole alkaloid (angustilongine L ...
Low, Yun Yee +6 more
core +1 more source
Synthesis of Marine Sponge Bisindole Alkaloids Dihydrohamacanthins
, 2016 A convergent synthesis of the marine sponge bisindole alkaloids dihydrohamacanthins is described. The synthesis centers on the construction of 3,5- and 3,6-linked pyrazinones and their reduction to the requisite piperazinones with sodium ...
Fumiko Y. Miyake (2702866) +2 more
core +1 more source
Brominated Bisindole Alkaloids from the Celtic Sea Sponge Spongosorites calcicola
Molecules, 2019 As part of an ongoing program to identify new bioactive compounds from Irish marine bioresources, we selected the subtidal sponge Spongosorites calcicola for chemical study, as fractions of this species displayed interesting cytotoxic bioactivities and ...
Laurence K. Jennings +6 more
doaj +1 more source
Bioresources and Bioprocessing, 2022 Indirubin is a bisindole compound for the treatment of chronic myelocytic leukemia. Here, we presented a structure-guided method to improve the activity of a flavin-containing monooxygenase (bFMO) for the efficient production of indirubin in Escherichia ...
Bing-Yao Sun +10 more
doaj +1 more source
ChemistryOpen, Volume 14, Issue 11, November 2025.Arenaria serpyllifolia extract exhibits strong antioxidant, antimicrobial, antibiofilm, and antiquorum sensing activities. Key compounds, including levoglucosan and guanosine, show potent CviR receptor binding. Violacein inhibition and molecular dynamics confirm their stability, highlighting their potential as quorum sensing inhibitors and therapeutic ...
Meryem Burcu Külahcı +5 more
wiley +1 more source
Biologically active indole and bisindole alkaloids from Tabernaemontana divaricata
, 2003 The ethanol extract of the leaves of Tabernaemontana divaricata (double flower variety) provided a total of 23 alkaloids, including the new aspidosperma alkaloids, taberhanine, voafinine, N-methylvoafinine, voafinidine, voalenine and the new bisindole ...
Lim, Tuck-Meng +5 more
core +1 more source