Results 61 to 70 of about 1,055 (166)

Structure of methyltransferase RedM that forms the dimethylpyrrolinium of the bisindole reductasporine. [PDF]

J Biol Chem
Bisindoles are biologically active natural products that arise from the oxidative dimerization of two molecules of l-tryptophan. In bacterial bisindole pathways, a core set of transformations is followed by the action of diverse tailoring enzymes that catalyze reactions that lead to diverse bisindole products.
Daniel-Ivad P, Ryan KS.
europepmc   +3 more sources

A Facile Synthesis of Deaza-Analogues of the Bisindole Marine Alkaloid Topsentin

Molecules, 2013
A series of substituted ethyl 1-[(tert-butoxycarbonyl)amino]-2-methyl-5- (1-methyl-1H-indol-3-yl)-4-[(1-methyl-1H-indol-3-yl)carbonyl]-1H-pyrrole-3-carboxylates were prepared in excellent yields (82-98%) by one-pot reactions between β-dicarbonyl ...
Gianfranco Favi, Cristina Ciancimino, Barbara Parrino, Orazio A. Attanasi, Virginia Spanò, Anna Carbone   +5 more
doaj   +1 more source

Biscarpamontamines A and B, an Aspidosperma−Iboga Bisindole Alkaloid and an Aspidosperma−Aspidosperma Bisindole Alkaloid, from Tabernaemontana sphaerocarpa

Journal of Natural Products, 2009
Two new bisindole alkaloids, biscarpamontamine A (1), possessing an aspidosperma-iboga-type skeleton, and biscarpamontamine B (2), having an aspidosperma-aspidosperma-type skeleton, were isolated from stems of Tabernaemontana sphaerocarpa, and their structures were elucidated on the basis of spectroscopic data analysis.
Kazumasa Zaima, -, Tomoko Hirata, -, Takahiro Hosoya, -, Yusuke Hirasawa, -, Koichiro Koyama, -, Abdul Rahman, -, Idha Kusumawati, -, Noor Cholies Zaini, -, Motoo Shiro, -, Hiroshi Morita, -   +9 more
openaire   +3 more sources

A Simple Strategy for Obtaining Bis-Indole Derivatives under Solvent Free Conditions [PDF]

Journal of Chemistry Letters
Bis-indole, a biomolecule which has acquired its own place in heterocyclic chemistry because of remarkable biological properties.These derivatives can be synthesized by the reaction of indole having carbonyl compound like aldehydes and ketones in the ...
Praveen Mugali, Daksha Hegde, Glanish Martis, Sneha O, Arunkumar Kerikai   +4 more
doaj   +1 more source

Attempted Synthesis of Vinca Alkaloids Condensed with Three-Membered Rings

Molecules, 2018
Our successful work for the synthesis of cyclopropanated vinblastine and its derivatives by the Simmons–Smith reaction was followed to build up further three-membered rings into the 14,15-position of the vindoline part of the dimer alkaloid ...
András Keglevich, Szabolcs Mayer, Réka Pápai, Áron Szigetvári, Zsuzsanna Sánta, Miklós Dékány, Csaba Szántay, Péter Keglevich, László Hazai   +8 more
doaj   +1 more source

A Simplified Procedure for Indole Alkaloid Extraction from Catharanthus roseus Combined with a Semi-synthetic Production Process for Vinblastine

Molecules, 2007
Dried leaves of Catharanthus roseus were extracted with aqueous acidic 0.1 M solution of HCl. Alkaloid-embonate complexes were obtained as precipitates by treating the extract with an alkaline (NaOH) solution of embonic acid (4,4-methylene-bis-3 ...
Marja-Liisa Riekkola, Aarre Huhtikangas, Tuulikki Seppänen-Laakso, Into Laakso, Arvind Verma   +4 more
doaj   +1 more source

The Chemistry of Grandifoline, a Bisindole Alkaloid

, 1979
Department of Pure Chemistry, University College of Science, 92, Acharya P. C.
openaire   +2 more sources

Synthesis and Cheminformatics-Directed Antibacterial Evaluation of Echinosulfonic Acid-Inspired Bis-Indole Alkaloids

Molecules
Synthetic efforts toward complex natural product (NP) scaffolds are useful ones, particularly those aimed at expanding their bioactive chemical space.
Darren C. Holland, Joshua B. Hayton, Milton J. Kiefel, Anthony R. Carroll   +3 more
doaj   +1 more source

First De Novo Synthesis of the Bisindole Alkaloid Vinblastine.

ChemInform, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire   +4 more sources

Chapter 3 Noniridoid Bisindole Alkaloids

, 1995
This chapter discusses that indole is a reactive nucleus prone to dimerization when it is isolated or a part of tryptamine or tryptophan, which themselves are reactive toward many functionalities. For these reasons, bisindoles, the majority of which are of iridoid origin, are frequently isolated in nature. Besides these “dimers,” there exists a growing
Sapi, J., Massiot, G.
openaire   +1 more source