Results 71 to 80 of about 2,045 (191)

Recent Advances in Drug Discovery from South African Marine Invertebrates

Marine Drugs, 2015
Recent developments in marine drug discovery from three South African marine invertebrates, the tube worm Cephalodiscus gilchristi, the ascidian Lissoclinum sp. and the sponge Topsentia pachastrelloides, are presented.
Michael T. Davies-Coleman, Clinton G. L. Veale   +1 more
doaj   +1 more source

Bisindoles : synthesis and reactions

, 1999
In this thesis, synthesis of various bisindoles have beendeveloped.2,3-Bis-(3-indolyl) succinic acid derivatives wereobtained via iodine promoted coupling of the trianion ofindole-3-acetic acid (IAA) or from the dianion of themethylester of IAA. These compounds were converted to2,3-bis(3-indolyl) maleimides (arcyriarubin analogues) by DDQoxidation ...
openaire   +2 more sources

Synthesis and Cheminformatics-Directed Antibacterial Evaluation of Echinosulfonic Acid-Inspired Bis-Indole Alkaloids

Molecules
Synthetic efforts toward complex natural product (NP) scaffolds are useful ones, particularly those aimed at expanding their bioactive chemical space.
Darren C. Holland, Joshua B. Hayton, Milton J. Kiefel, Anthony R. Carroll   +3 more
doaj   +1 more source

First De Novo Synthesis of the Bisindole Alkaloid Vinblastine.

ChemInform, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire   +4 more sources

Bis-Indole Derivatives as Dual Nuclear Receptor 4A1 (NR4A1) and NR4A2 Ligands

Biomolecules
Bis-indole derived compounds such as 1,1-bis(3′-indolyl)-1-(3,5-disubstitutedphenyl) methane (DIM-3,5) and the corresponding 4-hydroxyl analogs (DIM8-3,5) are NR4A1 ligands that act as inverse NR4A1 agonists and are potent inhibitors of tumor growth. The
Srijana Upadhyay, Amanuel Esayas Hailemariam, Fuada Mariyam, Zahin Hafiz, Gregory Martin, Jainish Kothari, Evan Farkas, Gargi Sivaram, Logan Bell, Ronald Tjalkens, Stephen Safe   +10 more
doaj   +1 more source

A novel anti-breast cancer stemness agent optimized from marine-derived bisindole Calcicamide A targeting the IL-6/JAK2/STAT3 signaling pathwayMendeley Data

European Journal of Medicinal Chemistry Reports
This study focuses on the optimization of Calcicamide A, a marine-derived bisindole natural product, as a novel anti-breast cancer stemness agent targeting the IL-6/STAT3 signaling pathway.
Shuanglin Qin, Siwen Hui, Jincai Wen, Si Yan, Hui Li, Guangshuai Zhang, Yan Liu, Ziwei Du, Qing Min, Wenjun Mao, Zhaofang Bai, Xiaohe Xiao   +11 more
doaj   +1 more source

Elucidation and derivatisation of bisindole biosynthesis pathways

, 2019
Bisindole natural products encompass the well-studied indolocarbazoles, such as rebeccamycin and staurosporine, among other minor classes including indolotryptolines and bisindolylpyrroles. Bisindole biosynthesis starts from L-tryptophan and forms highly aromatic bisindole scaffolds in a series of biosynthetic steps, which are catalysed by various core
openaire   +3 more sources

The Chemistry of Grandifoline, a Bisindole Alkaloid

, 1979
Department of Pure Chemistry, University College of Science, 92, Acharya P. C.
openaire   +1 more source

K⁺/Cu²⁺ Co-chelated diastereoselective Friedel-Crafts reaction with chiral <i>N</i>-sulfinyl ketimines for the facile synthesis of chiral bisindoles and their cytotoxicity. [PDF]

RSC Adv
Yan S, Xu M, Liu Y, Du Z, Zhang G, Liu Z, Xiao J, Guo X, Liao G, Min Q, Xie B, Qin S.   +11 more
europepmc   +1 more source

Total Synthesis of (-)-Owerreine and (-)-Anhydrovobtusine. [PDF]

Org Lett
Myeong IS, Pinto T, Movassaghi M.
europepmc   +1 more source