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Catalytic asymmetric formal nucleophilic C2-substitution of indoles via C2-umpolung toward 2,3’-bisindole atropisomers

Nature Communications
The electrophilic substitution of indoles represents the predominant functionalization strategy. However, due to the electron-rich nature of the indole scaffold, catalytic asymmetric nucleophilic substitution remains markedly underdeveloped—presenting ...
Cong-Hui Gao +6 more
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Bis-Indole Derivatives as Dual Nuclear Receptor 4A1 (NR4A1) and NR4A2 Ligands

Biomolecules
Bis-indole derived compounds such as 1,1-bis(3′-indolyl)-1-(3,5-disubstitutedphenyl) methane (DIM-3,5) and the corresponding 4-hydroxyl analogs (DIM8-3,5) are NR4A1 ligands that act as inverse NR4A1 agonists and are potent inhibitors of tumor growth. The
Srijana Upadhyay +10 more
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Elucidation and derivatisation of bisindole biosynthesis pathways

, 2019
Bisindole natural products encompass the well-studied indolocarbazoles, such as rebeccamycin and staurosporine, among other minor classes including indolotryptolines and bisindolylpyrroles. Bisindole biosynthesis starts from L-tryptophan and forms highly aromatic bisindole scaffolds in a series of biosynthetic steps, which are catalysed by various core
openaire +2 more sources

K+/Cu2+ Co-chelated diastereoselective Friedel-Crafts reaction with chiral N-sulfinyl ketimines for the facile synthesis of chiral bisindoles and their cytotoxicity. [PDF]