Results 71 to 80 of about 1,797 (189)
Assessment of Mechanisms Involved in Antinociception Produced by the Alkaloid Caulerpine
Molecules, 2014 In previous works we showed that oral administration of caulerpine, a bisindole alkaloid isolated from algae of the genus Caulerpa, produced antinociception when assessed in chemical and thermal models of nociception.
Luiz Henrique Agra Cavalcante-Silva +11 more
doaj +1 more source
CNS Neuroscience &Therapeutics, Volume 31, Issue 2, February 2025.Neuroinflammation and blood–brain barrier disruption play key roles in the progression of vascular dementia, and necroptosis is closely associated with vascular dementia. This review guides the prevention and treatment of vascular dementia by discussing the tumor necrosis factor‐α signaling pathway, destruction of endothelial cells, glial cells, and ...
Yuemin Qiu +10 more
wiley +1 more source
Cytotoxic Bisindole Alkaloids from a Marine Sponge Spongosorites sp.
, 2016 Three new bisindole alkaloids of the hamacanthin class (1−3) and one new bisindole alkaloid of the topsentin class (6) were isolated along with known bisindole alkaloids (4, 5, 7−11) from the MeOH extract of a marine sponge Spongosorites sp.
Qishi Sun (2681866) +7 more
core +1 more source
Food Science &Nutrition, Volume 12, Issue 12, Page 9951-9973, December 2024.This study discussed the therapeutic capacity of various polyphenols, terpenoids, and alkaloids on CRC via the PI3K/Akt/mTOR pathway. Each bioactive component causes various physiological processes, such as triggering free radical production, disruption of mitochondrial membrane potential, cell cycle arrest, inhibition of CRC stem cell migration ...
Kübra Demir +4 more
wiley +1 more source
Voacinol: a new bisindole alkaloid from Voacanga grandifolia (Miq) rolfe
, 1987 Voacinol, a new bisindole alkaloid from Voacanga grandifolia has been assigned a 14,14'-methylene-bis-18-hydroxytabersonine structure (1), on the basis of spectral ...
Govindachari, Tuticorin R. +3 more
core +1 more source
Protein & Cell, 2018 Lysosomes are degradation and signaling centers within the cell, and their dysfunction impairs a wide variety of cellular processes. To understand the cellular effect of lysosome damage, we screened natural small-molecule compounds that induce lysosomal ...
Yang Li +13 more
doaj +1 more source
Bisindoles : synthesis and reactions
, 1999 In this thesis, synthesis of various bisindoles have beendeveloped.2,3-Bis-(3-indolyl) succinic acid derivatives wereobtained via iodine promoted coupling of the trianion ofindole-3-acetic acid (IAA) or from the dianion of themethylester of IAA. These compounds were converted to2,3-bis(3-indolyl) maleimides (arcyriarubin analogues) by DDQoxidation ...
openaire +2 more sources
Synthesis and investigation of variously substituted bisindole derivatives. [PDF]
, 2021 Various indole isosteres, although not commonly found in the wild, are synthesized and, like bisindoles, have a wide variety of biological activities that are applicable in medicinal chemistry.
Valikonytė, Miglė,
core
Bis-indole chiral architectures for asymmetric catalysis
Nature CommunicationsChiral scaffolds are essential to the advancement of asymmetric synthesis, yet the development of privileged motifs that more effectively communicate asymmetry constitutes a grand challenge for chemists.
Junshan Lai +2 more
doaj +1 more source
A Facile Synthesis of Deaza-Analogues of the Bisindole Marine Alkaloid Topsentin
Molecules, 2013 A series of substituted ethyl 1-[(tert-butoxycarbonyl)amino]-2-methyl-5- (1-methyl-1H-indol-3-yl)-4-[(1-methyl-1H-indol-3-yl)carbonyl]-1H-pyrrole-3-carboxylates were prepared in excellent yields (82-98%) by one-pot reactions between β-dicarbonyl ...
Gianfranco Favi +5 more
doaj +1 more source