Results 81 to 90 of about 1,592 (193)

Image_5_CrERF5, an AP2/ERF Transcription Factor, Positively Regulates the Biosynthesis of Bisindole Alkaloids and Their Precursors in Catharanthus roseus.tif

, 2019
Catharanthus roseus contains a variety of monoterpenoid indole alkaloids (MIAs), among which bisindole alkaloids vinblastine and vincristine are well-known to have antitumor effects and widely used in clinical treatment.
Hang Wang (137566), Xiaofen Sun (378803), Zhiwei Xiong (6994181), Qifang Pan (140911), Bowen Peng (6565901), Kexuan Tang (14684), Chenyi Wang (1554715), Yanan Ma (2940933), Xueqing Fu (538646), Qian Shen (89639)   +9 more
core   +1 more source

C. elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death

Protein & Cell, 2018
Lysosomes are degradation and signaling centers within the cell, and their dysfunction impairs a wide variety of cellular processes. To understand the cellular effect of lysosome damage, we screened natural small-molecule compounds that induce lysosomal ...
Yang Li, Yu Zhang, Qiwen Gan, Meng Xu, Xiao Ding, Guihua Tang, Jingjing Liang, Kai Liu, Xuezhao Liu, Xin Wang, Lingli Guo, Zhiyang Gao, Xiaojiang Hao, Chonglin Yang   +13 more
doaj   +1 more source

The Therapeutic Effects of Bioactive Compounds on Colorectal Cancer via PI3K/Akt/mTOR Signaling Pathway: A Critical Review

Food Science &Nutrition, Volume 12, Issue 12, Page 9951-9973, December 2024.
This study discussed the therapeutic capacity of various polyphenols, terpenoids, and alkaloids on CRC via the PI3K/Akt/mTOR pathway. Each bioactive component causes various physiological processes, such as triggering free radical production, disruption of mitochondrial membrane potential, cell cycle arrest, inhibition of CRC stem cell migration ...
Kübra Demir, Rana Turgut, Selcen Şentürk, Handan Işıklar, Elif Günalan   +4 more
wiley   +1 more source

Angustifonines A and B, Cytotoxic Bisindole Alkaloids from Bousigonia angustifolia

, 2016
Two new bisindole alkaloids, angustifonines A (1) and B (2), comprising the union of a rearranged monoterpenoid quinoline and an aspidospermine alkaloid, as well as 27 known indole alkaloids were isolated from the twigs and leaves of Bousigonia ...
Yu Zhang (12946), Shun-lin Li (1854142), Xiao-jiang Hao (1854148), Yan-hui Fu (1854145), Ying-tong Di (1854151), Hong-ping He (1854139)   +5 more
core   +1 more source

10'-Hydroxyusambarensine, a New Antimalarial Bisindole Alkaloid from the Roots of Strychnos Usambarensis [PDF]

, 1999
peer reviewedReinvestigation of Strychnos usambarensis Gilg resulted in the isolation of a tertiary phenolic bisindole alkaloid, 10'-hydroxyusambarensine (1), which was identified by detailed spectroscopic methods.
Angenot, Luc, Frederich, Michel, Hayette, Marie-Pierre, De Mol, Patrick, Tits, Monique, Brandt, Viviane, Llabres, Gabriel, Penelle, Jacques   +7 more
core   +1 more source

A Facile Synthesis of Deaza-Analogues of the Bisindole Marine Alkaloid Topsentin

Molecules, 2013
A series of substituted ethyl 1-[(tert-butoxycarbonyl)amino]-2-methyl-5- (1-methyl-1H-indol-3-yl)-4-[(1-methyl-1H-indol-3-yl)carbonyl]-1H-pyrrole-3-carboxylates were prepared in excellent yields (82-98%) by one-pot reactions between β-dicarbonyl ...
Gianfranco Favi, Cristina Ciancimino, Barbara Parrino, Orazio A. Attanasi, Virginia Spanò, Anna Carbone   +5 more
doaj   +1 more source

Biscarpamontamines A and B, an Aspidosperma−Iboga Bisindole Alkaloid and an Aspidosperma−Aspidosperma Bisindole Alkaloid, from Tabernaemontana sphaerocarpa

, 2016
Two new bisindole alkaloids, biscarpamontamine A (1), possessing an aspidosperma−iboga-type skeleton, and biscarpamontamine B (2), having an aspidosperma−aspidosperma-type skeleton, were isolated from stems of Tabernaemontana sphaerocarpa, and their ...
Motoo Shiro (1670407), Idha Kusumawati (2330938), Hiroshi Morita (124362), Yusuke Hirasawa (1562092), Kazumasa Zaima (2290759), Noor Cholies Zaini (2330935), Tomoko Hirata (843960), Abdul Rahman (730178), Takahiro Hosoya (124351), Koichiro Koyama (2265847)   +9 more
core   +2 more sources

Biscarpamontamines A and B, an Aspidosperma−Iboga Bisindole Alkaloid and an Aspidosperma−Aspidosperma Bisindole Alkaloid, from Tabernaemontana sphaerocarpa

Journal of Natural Products, 2009
Two new bisindole alkaloids, biscarpamontamine A (1), possessing an aspidosperma-iboga-type skeleton, and biscarpamontamine B (2), having an aspidosperma-aspidosperma-type skeleton, were isolated from stems of Tabernaemontana sphaerocarpa, and their structures were elucidated on the basis of spectroscopic data analysis.
Kazumasa Zaima, -, Tomoko Hirata, -, Takahiro Hosoya, -, Yusuke Hirasawa, -, Koichiro Koyama, -, Abdul Rahman, -, Idha Kusumawati, -, Noor Cholies Zaini, -, Motoo Shiro, -, Hiroshi Morita, -   +9 more
openaire   +3 more sources

Image_1_CrERF5, an AP2/ERF Transcription Factor, Positively Regulates the Biosynthesis of Bisindole Alkaloids and Their Precursors in Catharanthus roseus.TIF

, 2019
Catharanthus roseus contains a variety of monoterpenoid indole alkaloids (MIAs), among which bisindole alkaloids vinblastine and vincristine are well-known to have antitumor effects and widely used in clinical treatment.
Hang Wang (137566), Xiaofen Sun (378803), Zhiwei Xiong (6994181), Qifang Pan (140911), Bowen Peng (6565901), Kexuan Tang (14684), Chenyi Wang (1554715), Yanan Ma (2940933), Xueqing Fu (538646), Qian Shen (89639)   +9 more
core   +1 more source

Bis-indole chiral architectures for asymmetric catalysis

Nature Communications
Chiral scaffolds are essential to the advancement of asymmetric synthesis, yet the development of privileged motifs that more effectively communicate asymmetry constitutes a grand challenge for chemists.
Junshan Lai, Benjamin List, Jolene P. Reid   +2 more
doaj   +1 more source