Results 91 to 100 of about 1,592 (193)
Bisindoles : synthesis and reactions
, 1999 In this thesis, synthesis of various bisindoles have beendeveloped.2,3-Bis-(3-indolyl) succinic acid derivatives wereobtained via iodine promoted coupling of the trianion ofindole-3-acetic acid (IAA) or from the dianion of themethylester of IAA. These compounds were converted to2,3-bis(3-indolyl) maleimides (arcyriarubin analogues) by DDQoxidation ...
openaire +2 more sources
Ajmaline, Oxindole, and Cytotoxic Macroline–Akuammiline Bisindole Alkaloids from Alstonia penangiana
, 2018 Examination of the EtOH extract of the Malayan Alstonia penangiana resulted in the isolation of 10 new alkaloids, comprising two ajmaline (1, 2), four macroline oxindole (3-6), and four macroline-akuammiline bisindole alkaloids (7-10).
Yong, Kien Thai +15 more
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A Simple Strategy for Obtaining Bis-Indole Derivatives under Solvent Free Conditions [PDF]
Journal of Chemistry LettersBis-indole, a biomolecule which has acquired its own place in heterocyclic chemistry because of remarkable biological properties.These derivatives can be synthesized by the reaction of indole having carbonyl compound like aldehydes and ketones in the ...
Praveen Mugali +4 more
doaj +1 more source
Structure of methyltransferase RedM that forms the dimethylpyrrolinium of the bisindole reductasporine. [PDF]
J Biol ChemBisindoles are biologically active natural products that arise from the oxidative dimerization of two molecules of l-tryptophan. In bacterial bisindole pathways, a core set of transformations is followed by the action of diverse tailoring enzymes that catalyze reactions that lead to diverse bisindole products.
Daniel-Ivad P, Ryan KS.
europepmc +3 more sources
, 2016 LCMS analysis of the extract and a cytotoxicity assay of the HPLC fractions generated from a small-scale extract of a Lipastrotethya sp. marine sponge demonstrated the presence of bisindole alkaloids that were associated with the cytotoxic activity.
Kentaro Takada (1476262) +4 more
core +1 more source
Attempted Synthesis of Vinca Alkaloids Condensed with Three-Membered Rings
Molecules, 2018 Our successful work for the synthesis of cyclopropanated vinblastine and its derivatives by the Simmons–Smith reaction was followed to build up further three-membered rings into the 14,15-position of the vindoline part of the dimer alkaloid ...
András Keglevich +8 more
doaj +1 more source
Molecules, 2017 Indirubin is an active component of the herbal ingredient ‘Danggui Longhui wan’, which was used for the treatment of inflammation and chronic myeloid leukemia in China.
Jana Tegethoff +5 more
doaj +1 more source
Molecules, 2007 Dried leaves of Catharanthus roseus were extracted with aqueous acidic 0.1 M solution of HCl. Alkaloid-embonate complexes were obtained as precipitates by treating the extract with an alkaline (NaOH) solution of embonic acid (4,4-methylene-bis-3 ...
Marja-Liisa Riekkola +4 more
doaj +1 more source
, 2017 A substrate-controlled regioselective arylation of 2-indolylmethanols with indoles has been established, which efficiently afforded bis(indolyl)methane and 3,3′-bisindole derivatives in high yields and with a broad substrate scope (up to 98% yield, 36 ...
Guo-Hao Li (3742135) +4 more
core +2 more sources
Recent Advances in Drug Discovery from South African Marine Invertebrates
Marine Drugs, 2015 Recent developments in marine drug discovery from three South African marine invertebrates, the tube worm Cephalodiscus gilchristi, the ascidian Lissoclinum sp. and the sponge Topsentia pachastrelloides, are presented.
Michael T. Davies-Coleman +1 more
doaj +1 more source