Results 51 to 60 of about 1,055 (166)

Divergent Pathways in the Biosynthesis of Bisindole Natural Products

Chemistry & Biology, 2009
Two molecules of the amino acid L-tryptophan are the biosynthetic precursors to a class of natural products named the "bisindoles." Hundreds of these bisindole molecules have been isolated from natural sources, and many of these molecules have potent medicinal properties.
Ryan, Katherine S., Drennan, Catherine L
openaire   +4 more sources

Convenient Synthesis of 6,7,12,13-Tetrahydro-5H-Cyclohepta[2,1-b:3,4-b’]diindole Derivatives Mediated by Hypervalent Iodine (III) Reagent

Molecules, 2019
Bisindolyl alkaloids represent a large family of natural and synthetic products that display various biological activities. Among the bisindole compounds, 6,7,12,13-tetrahydro-5H-cyclohepta[2,1-b:3,4-b’]diindoles have received little attention ...
Lei Peng, Xiaofei Zhang, Chunhao Yang
doaj   +1 more source

From data to discovery: leveraging big data in plant natural products biosynthesis research

The Plant Journal, Volume 122, Issue 6, June 2025.
SUMMARY Plant natural products or specialized metabolites play a vital role in drug discovery and development, with many clinically important derivatives such as the anticancer drugs topotecan (derived from the natural alkaloid camptothecin) and etoposide (derived from the natural polyphenol podophyllotoxin).
Matthew McConnachie, Tuan‐Anh Minh Nguyen, Truc Kim, Trinh‐Don Nguyen, Thu‐Thuy T. Dang   +4 more
wiley   +1 more source

2‐Aminoindoles and 2‐Iminoindolines as Viable Precursors of Indole‐Fused Nitrogenated Polyheterocycles

Advanced Synthesis &Catalysis, Volume 367, Issue 6, March 18, 2025.
Abstract The synthesis of architecturally complex polyheterocyclic structures embedding the indole ring represents a growing field of interest. Carbolines and their partially dehydro derivatives, pyrazinoindoles, indoloindoles, azepinoindoles and other medium‐sized derivatives are only some examples of indole‐containing polycyclic compounds featured by
Alessandro Palmieri, Marino Petrini
wiley   +1 more source

Bisindoles : synthesis and reactions

, 1999
In this thesis, synthesis of various bisindoles have beendeveloped.2,3-Bis-(3-indolyl) succinic acid derivatives wereobtained via iodine promoted coupling of the trianion ofindole-3-acetic acid (IAA) or from the dianion of themethylester of IAA. These compounds were converted to2,3-bis(3-indolyl) maleimides (arcyriarubin analogues) by DDQoxidation ...
openaire   +2 more sources

Assessment of Mechanisms Involved in Antinociception Produced by the Alkaloid Caulerpine

Molecules, 2014
In previous works we showed that oral administration of caulerpine, a bisindole alkaloid isolated from algae of the genus Caulerpa, produced antinociception when assessed in chemical and thermal models of nociception.
Luiz Henrique Agra Cavalcante-Silva, Maria Alice Pimentel Falcão, Ana Carolina Santana Vieira, Max Denisson Maurício Viana, João Xavier de Araújo-Júnior, Jéssica Celestino Ferreira Sousa, Tania Maria Sarmento da Silva, José Maria Barbosa-Filho, François Noël, George Emmanuel C. de Miranda, Bárbara Viviana de Oliveira Santos, Magna Suzana Alexandre-Moreira   +11 more
doaj   +1 more source

Advances in the Study of Necroptosis in Vascular Dementia: Focus on Blood–Brain Barrier and Neuroinflammation

CNS Neuroscience &Therapeutics, Volume 31, Issue 2, February 2025.
Neuroinflammation and blood–brain barrier disruption play key roles in the progression of vascular dementia, and necroptosis is closely associated with vascular dementia. This review guides the prevention and treatment of vascular dementia by discussing the tumor necrosis factor‐α signaling pathway, destruction of endothelial cells, glial cells, and ...
Yuemin Qiu, Lin Cheng, Yinyi Xiong, Ziying Liu, Chunxiao Shen, Liangliang Wang, Yujia Lu, Shufei Wei, Lushun Zhang, Seung Bum Yang, Xiaorong Zhang   +10 more
wiley   +1 more source

The Therapeutic Effects of Bioactive Compounds on Colorectal Cancer via PI3K/Akt/mTOR Signaling Pathway: A Critical Review

Food Science &Nutrition, Volume 12, Issue 12, Page 9951-9973, December 2024.
This study discussed the therapeutic capacity of various polyphenols, terpenoids, and alkaloids on CRC via the PI3K/Akt/mTOR pathway. Each bioactive component causes various physiological processes, such as triggering free radical production, disruption of mitochondrial membrane potential, cell cycle arrest, inhibition of CRC stem cell migration ...
Kübra Demir, Rana Turgut, Selcen Şentürk, Handan Işıklar, Elif Günalan   +4 more
wiley   +1 more source

C. elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death

Protein & Cell, 2018
Lysosomes are degradation and signaling centers within the cell, and their dysfunction impairs a wide variety of cellular processes. To understand the cellular effect of lysosome damage, we screened natural small-molecule compounds that induce lysosomal ...
Yang Li, Yu Zhang, Qiwen Gan, Meng Xu, Xiao Ding, Guihua Tang, Jingjing Liang, Kai Liu, Xuezhao Liu, Xin Wang, Lingli Guo, Zhiyang Gao, Xiaojiang Hao, Chonglin Yang   +13 more
doaj   +1 more source

Bis-indole chiral architectures for asymmetric catalysis

Nature Communications
Chiral scaffolds are essential to the advancement of asymmetric synthesis, yet the development of privileged motifs that more effectively communicate asymmetry constitutes a grand challenge for chemists.
Junshan Lai, Benjamin List, Jolene P. Reid   +2 more
doaj   +1 more source