Results 101 to 110 of about 899,795 (311)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

A novel bimodal lipidic contrast agent for cellular labelling and tumour MRI

, 2010
We have synthesized a bimodal lipidic molecule bearing both fluorophore and contrast agent signatures on the same structure in order to create a robust bimodal liposome for both magnetic resonance imaging (MRI) and fluorescence microscopy utility.
Kenny, Gavin, Kamaly, Nazila, Kalber, Tammy, Jorgensen, Michael, Kenny, G., Jorgensen, M.R., Kamaly, N., Bell, J.D., Miller, Andrew, Bell, Jimmy, Miller, A.D., Kalber, T.   +11 more
core   +1 more source

Analysis of DCE-MRI Data using a Nonnegative Elastic Net [PDF]

, 2010
We present a nonnegative Elastic Net approach for the analysis of Dynamic Contrast-Enhanced Magnetic Resonance Imaging data. A multi-compartment approach is considered, which is translated into a (restricted) least square model selection problem.
Gertheiss, Jan, Kärcher, Julia C., Schmid, Volker J.   +2 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Bimodal MRI/Fluorescence Nanoparticle Imaging Contrast Agent Targeting Prostate Cancer

Nanomaterials
We developed a novel site-specific bimodal MRI/fluorescence nanoparticle contrast agent targeting gastrin-releasing peptide receptors (GRPrs), which are overexpressed in aggressive prostate cancers. Biocompatible ultra-small superparamagnetic iron oxide (
Hang Xu, Ping Yu, Rajendra P. Bandari, Charles J. Smith, Michael R. Aro, Amolak Singh, Lixin Ma   +6 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Gadolinium-Based Contrast Agent-Related Toxicities

, 2018
In recent years, gadolinium-based contrast agents have been associated with different types of toxicity. In particular, nephrogenic systemic fibrosis, a progressive sclerotic-myxedematous systemic disease of unknown etiology, is related to gadolinium ...
Andrea Romano, Napolitano, Antonio, Luca Pasquini, Visconti, Emiliano, Antonio Napolitano, Daniela Longo, Emiliano Visconti, Tomà, Paolo, Paolo Tomà, Longo, Daniela, Rossi Espagnet, Maria Camilla, Pasquini, Luca, Romano, Andrea, Maria Camilla Rossi Espagnet   +13 more
core   +1 more source

Ultrasound Contrast Agent Microbubble Dynamics [PDF]

, 2010
Ultrasound contrast agents are traditionally used in ultrasound-assisted organ perfusion imaging. Recently the use of coated microbubbles has been proposed for molecular imaging applications where the bubbles are covered with a layer of targeting ligands
Michel Versluis, Nico de Jong, Versluis, Michel; id_orcid, Marlies Overvelde, Hendrik J. Vos, Overvelde, M.L.J., de Jong, N., Vos, Henk   +7 more
core   +1 more source

MRI-based identification of undifferentiated cells: looking at the two faces of Janus

International Journal of Nanomedicine, 2014
Ciprian Tomuleasa,1,2 Ioan Stefan Florian,3 Cristian Berce,4 Alexandru Irimie,5,6 Ioana Berindan-Neagoe,2,7,9 Andrei Cucuianu1,8 1Department of Hematology, Ion Chiricuta Cancer Center, Cluj Napoca, Romania; 2Research Center for Functional Genomics and ...
Tomuleasa C, Florian IS, Berce C, Irimie A, Berindan-Neagoe I, Cucuianu A   +5 more
doaj  

Perflutren lipid microspheres for echocardiogram contrast: a clinical case of anaphylaxis not caused by PEG

Allergy, Asthma & Clinical Immunology
Background Perflutren lipid microsphere suspension, sold under the brand name Definity®, is a microbubble ultrasound contrast agent. The microspheres contain octafluoropropane (C3F8) gas encapsulated by an outer lipid shell of phospholipids and a ...
Chloe Wang, Jackie Campbell, Harriet Lea-Banks, Erika Lee   +3 more
doaj   +1 more source