Results 61 to 70 of about 2,579,501 (301)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Glycosaminoglycans and Contrast Agents: The Role of Hyaluronic Acid as MRI Contrast Enhancer

Biomolecules, 2020
A comprehensive understanding of the behaviour of Glycosaminoglycans (GAGs) combined with imaging or therapeutic agents can be a key factor for the rational design of drug delivery and diagnostic systems.
Alfonso Maria Ponsiglione, Maria Russo, Enza Torino   +2 more
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions [PDF]

, 2015
The commercial availability of combined magnetic resonance imaging (MRI)/positron emission tomography (PET) scanners for clinical use has increased demand for easily prepared agents which offer signal or contrast in both modalities.
Al-Yassiry, M.M., Al-Yassiry, Mustafa M., Archibald, S.J., Archibald, Stephen J., Baghdadi, N., Baghdadi, Neazar, Burke, B.P., Burke, Benjamin P., Cawthorne, Christopher, Clemente, G.S., Clemente, Goncalo S., Clemente, Gonçalo S., Domarkas, Juozas, Gibbs, P., Gibbs, Peter, Kownacka, Alicja E., Lorch, Mark, Nigam, S., Nigam, Shubhanchi, Pickles, M., Pickles, Martin, Tripier, R., Tripier, Raphael, Tripier, Raphaël   +23 more
core   +2 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Gadolinium-Based Contrast Agents Hypersensitivity: A Case Series

Journal of Asthma and Allergy, 2021
Eleonora Nucera,1 Sara Urbani,1 Alessandro Buonomo,1 Tiziana De Pasquale,2 Angela Rizzi,1 Arianna Aruanno,1 Stefano Pucci2 1Allergy Unit, Fondazione Policlinico Universitario A.
Nucera E, Urbani S, Buonomo A, De Pasquale T, Rizzi A, Aruanno A, Pucci S   +6 more
doaj  

Ultrasound Needle Visibility in Contrast Mode Imaging: An In Vitro and Ex Vivo Study

Ultrasound International Open, 2017
Purpose To evaluate needle visibility in ultrasound under contrast mode conditions. Materials and Methods Needle visibility was evaluated for bevel, EchoTip® and shaft of 18G Chiba biopsy needle with a 9 MHz linear probe (GE Logiq E9).
Marga B. Rominger, Katharina Martini, Evelyn Dappa, Gilbert Puippe, Volker Klingmüller, Thomas Frauenfelder, Sergio J. Sanabria   +6 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Nanophosphor-Based Contrast Agents for Spectral X-ray Imaging

Nanomaterials, 2019
Lanthanide-based nanophosphors (NPhs) are herein developed as contrast agents for spectral X-ray imaging, highlighting the chemical, macromolecular and structural differences derived from ligand exchange on computed tomography (CT) and solvent ...
Kevin Smith, Matthew Getzin, Josephine J. Garfield, Sanika Suvarnapathaki, Gulden Camci-Unal, Ge Wang, Manos Gkikas   +6 more
doaj   +1 more source