Results 91 to 100 of about 3,372,624 (300)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Visual Contrast Enhancement Algorithm Based on Histogram Equalization

Sensors, 2015
Image enhancement techniques primarily improve the contrast of an image to lend it a better appearance. One of the popular enhancement methods is histogram equalization (HE) because of its simplicity and effectiveness.
Chih-Chung Ting, Bing-Fei Wu, Meng-Liang Chung, Chung-Cheng Chiu, Ya-Ching Wu   +4 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Denoising Autoencoder and Contrast Enhancement for RGB and GS Images with Gaussian Noise

Mathematics
Robust image processing systems require input images that closely resemble real-world scenes. However, external factors, such as adverse environmental conditions or errors in data transmission, can alter the captured image, leading to information loss ...
Armando Adrián Miranda-González, Alberto Jorge Rosales-Silva, Dante Mújica-Vargas, Edwards Ernesto Sánchez-Ramírez, Juan Pablo Francisco Posadas-Durán, Dilan Uriostegui-Hernandez, Erick Velázquez-Lozada, Francisco Javier Gallegos-Funes   +7 more
doaj   +1 more source

Speckle Reduction with Attenuation Compensation for Skin OCT Images Enhancement [PDF]

The enhancement of skin image in optical coherence tomography (OCT) imaging can help dermatologists to investigate tissue layers more accurately, hence the more efficient diagnosis.
Hojjatoleslami, Ali, Avanaki, Mohammad R. N.   +1 more
core  

The utility of three-dimensional dynamic contrast-enhanced [PDF]

, 2010
Aneurysmal bone cysts (ABCs) are classified as bone-related lesions based on the 2005 World Health Organization histological classification of odontogenic tumors.
Nagatsuka, Hitoshi, Yanagi, Yoshinobu, Konouchi, Hironobu, Hisatomi, Miki, Mariko Fujita, Asaumi, Jun-ichi, Hironobu Konouchi, Hidenobu Matsuzaki, Katase, Naoki, Yoshinobu Yanagi, Hitoshi Nagatsuka, Matsuzaki, Hidenobu, Fujita, Mariko, Miki Hisatomi, Naoki Katase, Jun-ichi Asaumi   +15 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source