Results 51 to 60 of about 1,757,364 (306)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The Evaluation of Yellow vs. Blue Color Contrast Sensitivity pre and Post LASIK [PDF]

Iranian Journal of Medical Physics, 2007
Introduction: contrast sensitivity is one of the most important psychophysical tests that may be used for the evaluation of refractive state of eye and retinal image quality. Yellow vs. blue color contrast sensitivity may be more suitable in this regard.
S. Heydarian, , M. Jabarvand Behrooz, E. Jafarzadehpour, R. Vahabbi   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Improvement or worsening of human contrast sensitivity due to blue light attenuation at 450 nm [PDF]

, 2020
Purpose: The work was aimed at comparing contrast sensitivity performance in an indoor environment with two filters, which differ only in the presence of a band at 450±20 nm in the transmittance spectrum.
Larcher, Silvano, Vlasak, Natalia, Cozza, Federica, Nigrotti, Gabriele, Zeri, Fabrizio, Braga, Chiara, Tavazzi, Silvia   +6 more
core   +1 more source

Impact of Keratoconus on Contrast Sensitivity

Journal of Health Science and Medical Research (JHSMR)
Objective: Keratoconus (KC) disrupts corneal shape, leading to irregular astigmatism and increased higher-order aberrations (HOA), ultimately affecting visual quality.
Law Yih Zhen, Fakhruddin Shamsheer Barodawala   +1 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

No Evidence of Reduced Contrast Sensitivity in Migraine-with-Aura for Large, Narrowband, Centrally Presented Noise-Masked Stimuli [PDF]

, 2021
Individuals with migraine aura show differences in visual perception compared to control groups. Measures of contrast sensitivity have suggested that people with migraine aura are less able to exclude external visual noise, and that this relates to ...
Louise O’Hare, O'Hare, L, Paul B. Hibbard, Asher, Jordi M, O'Hare, Louise, Asher, JM, Hibbard, PB, Jordi M. Asher, Hibbard, Paul B, Asher, Jordi, O’Hare, Louise, Hibbard, Paul   +11 more
core   +1 more source

Development of Dynamic Contrast Sensitivity Chart

British and Irish Orthoptic Journal
Background: Dynamic visual acuity (DVA) is a complex visual function that requires the observer to detect a moving target, to visually acquire it by eye movements, and to resolve critical details contained in it, in a relatively brief time exposure ...
Nikhita Jacob, Vandana Kamath, B. N. Sanjay   +2 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source