Results 61 to 70 of about 7,877,089 (295)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

The Measurement of Contrast Sensitivity in Near Vision: The Use of a Digital System vs. a Conventional Printed Test

Technologies
In recent years, there has been intense development of digital diagnostic tests for vision. All of these tests must be validated for clinical use.
Kevin J. Mena-Guevara, David P. Piñero, María José Luque, Dolores de Fez   +3 more
doaj   +1 more source

Contrast sensitivity in patients with diabetes mellitus [PDF]

Medicinski Podmladak, 2018
Introduction: Diabetic retinopathy is one of the major complications of diabetes mellitus. It is a progressive disease that includes following stages: no apparent DR, non-proliferative DR and proliferative DR.
Mirković Jelena, Risimić Dijana
doaj  

Temporal Expectation Enhances Contrast Sensitivity by Phase Entrainment of Low-Frequency Oscillations in Visual Cortex

Journal of Neuroscience, 2013
Although it is increasingly accepted that temporal expectation can modulate early perceptual processing, the underlying neural computations remain unknown.
A. Cravo, G. Rohenkohl, V. Wyart, A. Nobre   +3 more
semanticscholar   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Evaluation of contrast sensitivity in visually impaired individuals using K-CS test. A novel smartphone-based contrast sensitivity test-Design and validation.

PLoS ONE
BackgroundTo describe the development and investigate the accuracy of a novel smartphone-based Contrast Sensitivity (CS) application, the K-CS test.MethodsA total of 67 visually impaired and 50 normal participants were examined monocularly using the ...
Vasileios Karampatakis, Eleni P Papadopoulou, Stavroula Almpanidou, Leonidas Karamitopoulos, Diamantis Almaliotis   +4 more
doaj   +3 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Sensitivity to Auditory Velocity Contrast [PDF]

Scientific Reports, 2016
AbstractA natural auditory scene often contains sound moving at varying velocities. Using a velocity contrast paradigm, we compared sensitivity to velocity changes between continuous and discontinuous trajectories. Subjects compared the velocities of two stimulus intervals that moved along a single trajectory, with and without a 1 second inter stimulus
Shannon M. Locke, Johahn Leung, Simon Carlile   +2 more
openaire   +2 more sources