Results 131 to 140 of about 12,459,419 (300)
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Evaluating Prefix-Driven Contrastive Learning for Semantic Search in High-Impact Societal Domains [PDF]
openSemantic search is a fundamental component of information retrieval, particularly in high- impact domains where extracting precise and contextually relevant information is crucial.
YILMAZ, CEREN
core
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Perspective (Institute for Christian Studies)
, 1996 Three new faculty appointments spark excitement [Adrienne Dengerink Chaplin; Carroll Guen Hart; Douglas Blomberg], From the President: Short Catechism [roots of the Institute’s Reformed vision of Education], Students [M. Phil. F.
Fernhout, Harry +2 more
core +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The relationship of duration and contrastive accent in Chinese sentences
, 2000 As has been studied, when a word in a sentence is focused on, its all syllables will be lengthened (Wieke Eefting, 1991). But sometimes, contrastive accent may be focused on a phrase or a syllable; and in Chinese, because most syllables bear some meaning,
X. Zhong, Y. Yang
core +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Contrastive Analysis of Bulgarian and Russian Syntax Peculiarities
Slovene, 2019 [Rev. of: Gradinarova Alla A., Essays on the Comparative Syntax of Bulgarian and Russian, Sofia: Iztok-Zapad, 2017, 500 pp.] This article presents a review of the book by a major Bulgarian researcher of Russian, professor of Sofia University “St. Kliment
Elena Yu. Ivanova
doaj
RNA‐related functions of BRCA2 in transcription, replication, and genome stability
FEBS Letters, EarlyView.Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda +2 more
wiley +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source