Results 111 to 120 of about 50,253,444 (339)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
, 2017 Contrastive terminography Contrastive methods have long been employed in lexicography, in particular in bi- and multilingual dictionary projects. The main rationale for this is the necessity to comprehensively study, i.e.
Marek Wojciech Łukasik +1 more
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Contrastive rhetoric of English persuasive correspondence in the Thai business context : cross-cultural sales promotion, request and invitation [PDF]
This research focuses on the contrastive analysis of authentic persuasive business correspondence written in English by Thai speakers and native English speakers in the Thai business context. Three types of persuasive correspondence - sales promotion,
Chakorn, Ora-Ong
core
Contrastive reasons and promotion [PDF]
, 2014 A promising but underexplored view about normative reasons is contrastivism, which holds that considerations are fundamentally reasons for things only relative to sets of alternatives.
Snedegar, Justin
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Arabic / English / Arabic translation : shifts of cohesive markers in the translation of argumentative texts : a contrastive Arabic-English text-linguistic study [PDF]
, 2004 EThOS - Electronic Theses Online ServiceGBUnited ...
Al-Amri, Khalid Hadi
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
, 1990 1 online resource (PDF, page 392-410)Sober, Elliott. (1990). Contrastive empiricism.
Sober, Elliott
core