Results 91 to 100 of about 15,651,541 (299)

Emerging Trends in Computing, Informatics, Systems Sciences, and Engineering

, 2013
Emerging Trends in Computing, Informatics, Systems Sciences, and Engineering includes a set of rigorously reviewed world-class manuscripts addressing and detailing state-of-the-art research projects in the areas of  Industrial Electronics, Technology ...
Sobh, Tarek, Elleithy, Khaled
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Segmentation and generalisation for writing skills transfer from humans to robots

Cognitive Computation and Systems, 2019
In this study, the authors present an enhanced generalised teaching by demonstration technique for a KUKA iiwa robot. Movements are recorded from a human operator, and then the recorded data are sent to be segmented via MATLAB by using the difference ...
Chunxu Li, Chenguang Yang, Cinzia Giannetti   +2 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Multi-Agent Active Perception Based on Reinforcement Learning and POMDP

IEEE Access
In this article, we address a form of active perception characterized by curiosity-driven, open-ended exploration with intrinsic motivation, carried out by a group of agents.
Tarik Selimovic, Marijana Peti, Stjepan Bogdan   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Cycling Segments Multimodal Analysis and Classification Using Neural Networks

Applied Sciences, 2017
This paper presents methodology for the processing of GPS and heart rate signals acquired during long-term physical activities. The data analysed include geo-positioning and heart rate multichannel signals recorded for 272.2 h of cycling across the Andes
Aleš Procházka, Saeed Vaseghi, Hana Charvátová, Ondřej Ťupa, Oldřich Vyšata   +4 more
doaj   +1 more source

Engineering control systems and computing in the 90s

Journal of Computational and Applied Mathematics, 1988
The relationship between computing hardware/software and engineering control systems is projected into the next decade, and conjectures are made as to the areas of control and system theory that will most benefit from various types of computing advances.
openaire   +1 more source

Fulfilling the vision of autonomic computing [PDF]

, 2010
Efforts since 2001 to design self-managing systems have yielded many impressive achievements, yet the original vision of autonomic computing remains unfulfilled.
Nixon, Paddy, Hinchey, Mike, Paddy Nixon (12588778), Roy Sterritt (12616153), Dobson, Simon, Mike Hinchey (12615844), Sterritt, Roy, Simon Dobson (365078), Sterritt, Roy; id_orcid, Dobson, Simon; id_orcid   +9 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source