Results 61 to 70 of about 15,651,541 (299)

Evolutionary Computing within Grid Environment. [PDF]

, 2007
Evolutionary computing (EC) techniques such as genetic algorithm (GA), genetic programming (GP), evolutionary programming (EP) and evolution strategies (ES) mimic nature through natural selection to perform complex optimisation processes that require ...
Tiwari, Ashutosh, Roy, Rajkumar, Goteng, Gokop   +2 more
core   +4 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Distributed monitoring and control of future power systems via grid computing [PDF]

, 2006
It is now widely accepted within the electrical power supply industry that future power systems operates with significantly larger numbers of small-scale highly dispersed generation units that use renewable energy sources and also reduce carbon dioxide ...
Kyberd, P, Huang, C, Taylor, RJ, Irving, MR, P.R. Hobson, P. Kyberd, Taylor, GA, G.A. Taylor, M.R. Irving, R.J. Taylor, Hobson, PR, C. Huang   +11 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Engineering knowledge for engineering grid applications

, 2002
Computing increasingly addresses collaboration; sharing; and interaction involving distributed resources. This has been fuelled in part by the emergence of Grid technologies and web services. Drawing on our expertise in the Geodise project1.
Keane, Andy, F Tao, N R Shadbolt, Cox, S.J., Keane, Andy J, C Goble, Goble, Carole A, Roberts, A., L. Chen, Shadbolt, N., Roberts, Angus, Tao, F., Tao, Feng, Cox, Simon J, Shadbolt, Nigel R, A. J. Keane, A. Roberts, Shadbolt, Nigel, Smart, Paul, Keane, A.J., Smart, P., Chen, Liming, Goble, Carole, P. Smart, Goble, C., Smart, Paul R, S. J. Cox, Cox, Simon J.   +27 more
core   +2 more sources

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

A new approach for an induced coagulation of particulate matter through thermo-acoustic agglomeration

, 2023
49th International Congress and Exposition on Noise Control Engineering (INTERNOISE 2020): Advances in Noise and Vibration Control Technology: Seoul, Korea, 23-26 August 2020202312 bcchVersion of RecordRGCPublishedPublisher ...
Yu, JCW, Li, Y, Lai, SK, Zhang, Y
core  

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source