Results 101 to 110 of about 1,342,466 (275)
THE SYNTHESIS AND EVALUATION OF THE FUNCTIONAL SYSTEM OF THE AUTOMATIC CONTROL
, 1996 The object of investigation: the complex dynamic objects automatic control. The purpose of the work: the development of methods of the automated synthesis and evalaution of the automatic control system functioning efficiency, which have a common ...
Gorin, Dmitry Yurievich
core
Glottal Spectral Separation for Speech Synthesis [PDF]
, 2014 This paper proposes an analysis method to separate the glottal source and vocal tract components of speech that is called Glottal Spectral Separation (GSS). This method can produce high-quality synthetic speech using an acoustic glottal source model.
Renals, Steve +3 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
ANALYSIS AND SYNTHESIS OF ELECTRIC POWER SYSTEM OBSERVABILITY
, 1992 The criteria have been determined, the algorithms of observability analysis and synthesis, solutions of non-observed state evaluation problem and interaction design methods have been developed, the problem of weak places has been studied.
Golub, Irina Ivanovna
core
Phase Plane Analysis of Feed Back Control System having Two Nonlinear Gain Elements. [PDF]
, 1959 one lf the formidable problems in the area of feed back control concerns the analysis and synthesis of nonlinear systems, and several methods have been employed for treating feed back control system with nonlinear elements.This paper describes a method ...
藤宗, 寛治 +3 more
core
Hybrid Systems in Process Control
, 1996 Modeling and control of hybrid systems, with particular emphasis on process control applications, are considered in this article. Based on a number of observations on typical mixed discrete and continuous features for such applications, a fairly general ...
Tittus, Michael +7 more
core +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source