Results 81 to 90 of about 1,342,466 (275)
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Algorithms for analysis and synthesis of systems with synchronization errors
, 2012 This thesis addresses currently open problems in the stability analysis and control of discrete linear systems with clock synchronisation errors. Such errors can lead to insta- bility of an overall system even in the case when it is composed of linear ...
Przedwojski, Marek
core
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Flight control system manuals.
, 1952 1. Methods of analysis and synthesis of piloted aircraft flight control system.--2. Dynamics of the airframe.--2. Suppl. Addendum.--3. The human pilot.--4. The hydraulic system.--5. The artificial feel system.--6.
Northrop Aircraft, Inc., Hawthorne, Calif. +1 more
core
Synthesis of discrete-logic control systems
, 2018 The tutorial discusses the engineering methods of analysis and synthesis of discrete-logic control systems for industrial machinery based on the unit of the algebra of logic and sequences of their work; given an improved universal method, allowing fast ...
Николай Чикуров +1 more
core +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Energy methods for lossless systems using quadratic differential forms
, 2008 In this thesis, we study the properties of lossless systems using the concept of quadratic differential forms (QDFs). Based on observation of physical linear lossless systems, we define a lossless system as one for which there exists a QDF known as an ...
Rao, Shodhan
core +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source