Results 81 to 90 of about 1,323,126 (262)

A unified modelling system for service representation [PDF]

, 2012
This PHD project aims to develop a service design system which has a customer-centric view and delivers a balance between profit and value for both customers and service providers.
Gkekas, Konstantinos
core   +4 more sources

Algorithms for analysis and synthesis of systems with synchronization errors

, 2012
This thesis addresses currently open problems in the stability analysis and control of discrete linear systems with clock synchronisation errors. Such errors can lead to insta- bility of an overall system even in the case when it is composed of linear ...
Przedwojski, Marek
core  

Identification and data-driven model reduction of state-space representations of lossless and dissipative systems from noise-free data [PDF]

, 2011
We illustrate procedures to identify a state-space representation of a lossless- or dissipative system from a given noise-free trajectory; important special cases are passive- and bounded-real systems.
Trentelman, Harry, Rapisarda, P., Paolo Rapisarda, Trentelman, H.L., Trentelman, H.L.,, P. Rapisarda, Rapisarda, P.,, Harry L. Trentelman, H.L. Trentelman, Rapisarda, Paolo   +9 more
core   +2 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Energy methods for lossless systems using quadratic differential forms

, 2008
In this thesis, we study the properties of lossless systems using the concept of quadratic differential forms (QDFs). Based on observation of physical linear lossless systems, we define a lossless system as one for which there exists a QDF known as an ...
Rao, Shodhan
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The Methods for Synthesis and Analysis Controlled Time Delay System with Required Damping Factor

, 2012
D-decomposition method in the area of relative stability, developed from Loo [7] in order to separate constant time settling area in parametric space which ensures the system having predefined settling time.[4]. This paper develops the methods for synthesis and analysis of controlled-loop system with proportional regulator for transport and dosing ...
Đorđević, Vladimir, Brašić, Vesna
openaire   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source