Results 61 to 70 of about 1,342,466 (275)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
IET Control Theory & Applications, 2022 For the speed control system of autonomous electric vehicle (AEV), challenge happens with how to determine an appropriate driving speed to satisfy the dynamic environment while resisting uncertainty and disturbance.
Guangfei Xu +7 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Gravity compensation and optimal control of actuated multibody system dynamics
IET Control Theory & Applications, 2022 This work investigates the gravity compensation topic, from a control perspective. The gravity could be levelled by a compensating mechanical system or in the control law, such as proportional derivative (PD) plus gravity, sliding mode control, or ...
Saeed Rafee Nekoo +2 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Design of uncertainty and disturbance estimator based tracking control for fuzzy switched systems
IET Control Theory & Applications, 2021 In this paper, an uncertainty and disturbance estimator (UDE)‐based control is employed to ensure the finite‐time tracking and disturbance rejection performance for a class of Takagi–Sugeno fuzzy switched systems including additive time‐varying delays ...
R. Sakthivel +3 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
IET Control Theory & Applications, 2021 This paper considers the problem of adaptive fault estimation and fault‐tolerant tracking control for a class of uncertain nonlinear systems with model uncertainty and process fault.
Yang Wu, Guoshan Zhang, Libing Wu
doaj +1 more source
Synthesis of aircraft structures using integrated design and analysis methods [PDF]
, 1978 A systematic research is reported to develop and validate methods for structural sizing of an airframe designed with the use of composite materials and active controls. This research program includes procedures for computing aeroelastic loads, static and
Goetz, R. C. +1 more
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