Results 71 to 80 of about 1,342,466 (275)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Composite control with observer for switched stochastic systems subject to multiple disturbances and input saturation

IET Control Theory & Applications, 2021
This paper investigates the composite hierarchical anti‐disturbance control problem for switched systems with saturating inputs, in which the multiple disturbances including normal‐bounded disturbances, white noises and nonlinear uncertainties are ...
Yunliang Wei, Guo‐Ping Liu, Jun Yang
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

On robust stability of switched homogeneous systems

IET Control Theory & Applications, 2021
This paper analyses the robust stability of a class of homogeneous systems where a relation among the high‐order term, the decay rate and the domain of attraction of the system is explicitly established.
Hao Yang, Dong Zhao, Bin Jiang, Shihong Ding   +3 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Event‐triggered control of singularly perturbed linear system with DoS attacks

IET Control Theory & Applications, 2021
This paper presents the event‐triggered control problem of linear singularly perturbed systems in the presence of denial‐of‐service attacks. To save the communication and computing resources, event‐triggered mechanisms in two transmission channels are ...
Xiang Ren, Fei Hao
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Average dwell-time mMethod to L2-gain analysis and control synthesis for uncertain switched nonlinear systems.

, 2008
This paper addresses the L2-gain analysis and control synthesis problem for a class of switched nonlinear systems affected by both time-varying uncertainties and external disturbances. Firstly, the L2-gain for the autonomous switched disturbed uncertain system is analyzed.
Min Wang, Georgi M. Dimirovski, Jun Zhao 0002   +2 more
openaire   +2 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

CAutoCSD-evolutionary search and optimisation enabled computer automated control system design [PDF]

, 2004
This paper attempts to set a unified scene for various linear time-invariant (LTI) control system design schemes, by transforming the existing concept of 'Computer-Aided Control System Design' (CACSD) to the novel 'Computer-Automated Control System ...
Li, Y, Ang, K.H., Kashiwagi, H., Li, Y., Tan, K.C., Chong, G.C.Y., Feng, W., Kiam Heong Ang, Gregory C. Y. Chong, Yun Li, Kay Chen Tan, Wenyuan Feng, Hiroshi Kashiwagi   +12 more
core   +1 more source