Results 61 to 70 of about 89,621 (279)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Evaluación de ovitrampas letales como estrategia para el control de Aedes aegypti

Biomédica: revista del Instituto Nacional de Salud, 2014
Introducción. El dengue es una enfermedad viral de transmisión vectorial de importancia en salud pública. La ausencia de una vacuna ha llevado a que las acciones de control se enfoquen principalmente en la disminución del mosquito vector.
Marcela Quimbayo, Guillermo Rúa-Uribe, Gabriel Parra-Henao, Carolina Torres   +3 more
doaj   +1 more source

Dynamics of abelian subgroups of GL(n, C): a structure's Theorem

, 2005
In this paper, we characterize the dynamic of every abelian subgroups $\mathcal{G}$ of GL($n$, $\mathbb{K}$), $\mathbb{K} = \mathbb{R}$ or $\mathbb{C}$. We show that there exists a $\mathcal{G}$-invariant, dense open set $U$ in $\mathbb{K}^{n}$ saturated
Adlene Ayadi, F. Dal’bo, H. Marzougui, Habib Marzougui, M. S. Kulikov   +4 more
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Vectorial dissipative solitons in vertical-cavity surface-emitting Lasers with delays

, 2014
We show that the nonlinear polarization dynamics of a vertical-cavity surface-emitting laser placed into an external cavity leads to the formation of temporal vectorial dissipative solitons. These solitons arise as cycles in the polarization orientation,
A Perez-Serrano, C Lecaplain, CA Klausmeier, DY Tang, F Leo, F Marino, FT Arecchi, G Giacomelli, G Nicolis, H Zhang, HU Bödeker, J Javaloyes, J Javaloyes, J Javaloyes, J. Javaloyes, JK Jang, JU Kang, K Choquette, KD Choquette, L Lugiato, M Marconi, M San Miguel, M Tlidi, M Virte, M. Giudici, M. Marconi, N Akhmediev, N Akhmediev, NN Rosanov, O Descalzi, P Coullet, P Genevet, P Grelu, P Grelu, QL Williams, S Barland, S Chouli, S Fauve, S. Balle, S. Barland, ST Cundiff, T Ackemann, T Elsass, WJ Firth, YV Kartashov   +44 more
core   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Modelling the Influence of Climate and Vector Control Interventions on Arbovirus Transmission

Viruses
Most mathematical models that assess the vectorial capacity of disease-transmitting insects typically focus on the influence of climatic factors to predict variations across different times and locations, or examine the impact of vector control ...
Emma L. Fairbanks, Janet M. Daly, Michael J. Tildesley   +2 more
doaj   +1 more source

Hallazgo de Panstrongylus rufotuberculatus (Champion, 1899) (Hemiptera, Reduviidae, Triatominae) en ambiente domiciliario en la Región Piura, Perú Intra-domiciliary capture of Panstrongylus rufotuberculatus (Champion, 1899) (Hemiptera, Reduviidae, Triatominae) in Piura, Peru

Cadernos de Saúde Pública, 2007
Panstrongylus rufotuberculatus presenta una amplia distribución en América Central y del Sur con un comportamiento de especie silvestre. En el Perú ha sido registrado en Tumbes, Piura y Cuzco, siendo descrito en casas de localidades de este último ...
Edgard Marín, Rosa Santillán, César Cuba, José Jurberg, Cleber Galvão   +4 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Vectorial structure of a hard-edged-diffracted four-petal Gaussian beam in the far field

, 2010
Based on the vector angular spectrum method and the stationary phase method and the fact that a circular aperture function can be expanded into a finite sum of complex Gaussian functions, the analytical vectorial structure of a four-petal Gaussian beam ...
Cai, Cai, Chen, Chu, Deng, Deng, Duan, Duan, Gao, Grynberg, Guo, Jianbang Guo, Kehao Li, Keqing Lu, Le Berre, Mandel, Martínez-Herrero, Reicherter, Steven Kurti, Tang, Tang, Wen, Wu, Xuewen Long, Yang, Yuhong Zhang, Zhang, Zhao, Zhou, Zhou, Zhou   +30 more
core   +1 more source