Results 71 to 80 of about 89,621 (279)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Vigilancia y control vectorial

, 2016
El documento se encuentra en versión ...
Minchan Calderón, Alicia, Vásquez León, Blanca Gladys, Vásquez Arangoitia, Claudia Liliana, Moreno Gutiérrez, Diamantina Lorgia, Ordoñes Fuentes, Flor de María, Rojas Arteaga, Norka Hilda, Torres Capcha, Peter Alexander, Ponce Jara, Ruby Nelly   +7 more
openaire   +3 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Universal Vectorial and Ultrasensitive Nanomechanical Force Field Sensor

, 2016
Miniaturization of force probes into nanomechanical oscillators enables ultrasensitive investigations of forces on dimensions smaller than their characteristic length scale.
A Cleland, A Gloppe, A Nigues, A Siria, AW Rodriguez, B Derjaguin, B Pigeau, BD Terris, Benjamin Besga, Benjamin Pigeau, CL Degen, CM Mate, D Cadeddu, D Ramos, D Rugar, E Gil-Santos, E Sage, F Chen, G Binnig, I Yeo, J Chaste, J Gieseler, J Moser, J Nichol, JM Nichol, K Jensen, K Karrai, K Schwab, KL Ekinci, Laure Mercier de Lépinay, M Ganzhorn, M Montinaro, M Pinard, MS Hanay, MS Rodrigues, O Arcizet, Olivier Arcizet, P Bushev, P Ovartchaiyapong, P Peddibhotla, Pascal Vincent, Philippe Poncharal, R Garcia, RO Behunin, S Kuehn, T Barois, T Faust, T Li, Y Martin   +48 more
core   +3 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Polimorfismo entre poblaciones de Lutzomyia longipalpis, insecto transmisor de leishmaniosis visceral, sugiere la existencia de un complejo de especies

Biomédica: revista del Instituto Nacional de Salud, 1999
Lutzomyia longipalpls se ha incriminado como el principal vector de leishmaniosis visceral en América latina y recientemente se ha asociado también con la transmisión de leishmaniosis cutánea en algunos países de Centroamérica.
Sandra Uribe
doaj   +1 more source

Entanglement-controlled Vectorial Quantum Meta-Holography

Abstract Metasurfaces can precisely manipulate the amplitude, phase, and polarization of incident light through subwavelength structures, greatly advancing the quantum meta-holographic imaging. However, the current methods of using quantum holography only control either the amplitude or the phase on the imaging plane, so the resulted scalar ...
Yan Li, Sheng Ye, Yue Han, Li-Zheng Liu, Weiping Wan, Ruiqi Wang, Mingna Xun, Qiang Li, Qihuang Gong, Jianwei Wang   +9 more
openaire   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Regularising Non-linear Models Using Feature Side-information

, 2017
Very often features come with their own vectorial descriptions which provide detailed information about their properties. We refer to these vectorial descriptions as feature side-information.
Kalousis, Alexandros, Mollaysa, Amina, Strasser, Pablo   +2 more
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source