Results 71 to 80 of about 190,239 (263)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Comparative efficacy of controlled atmospheres against two stored product insects

Journal of Crop Protection, 2013
Effect of controlled atmospheres (CAs) at various concentrations of CO2, N2 and O2 on the lethal times of Tribolium castaneum and Trogoderma granarium was investigated at 20 and 30 ºC.
Mohamed Azab, Ahmed Darwish, Refaat Mohamed, Marwa Sanad   +3 more
doaj  

Responses of Pigs to Stunning with Nitrogen Filled High-Expansion Foam

Animals, 2020
Nitrogen gas (N2) delivered in high expansion foam in a closed container could be a feasible method for humanely stunning pigs. This study aimed to evaluate potential aversion in pigs to the N2 foam method and its effect on stun quality. Furthermore, the
Cecilia Lindahl, Erik Sindhøj, Rebecka Brattlund Hellgren, Charlotte Berg, Anna Wallenbeck   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Effects of pre- and postharvest factors on browning in Braeburn

Horticultural Science, 2014
The effects of several pre- and postharvest factors on apple cv. Braeburn browning disorder (BBD) incidence using a nine-factor experimental design has been investigated.
D. Hatoum, K. Buts, M.L.A.T.M. Hertog, A.H. Geeraerd, A. Schenk, J. Vercammen, B.M. Nicolai   +6 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Qualidade da farinha obtida de grãos de trigo fumigados com dióxido de carbono e fosfina Quality of flour obtained from wheat grains fumigated with carbon dioxide and phosphine

Revista Brasileira de Engenharia Agrícola e Ambiental, 2002
Avaliar a qualidade da farinha obtida de grãos de trigo fumigados com atmosfera sintética (21% de CO2) associada a níveis reduzidos de fosfina (0,25, 0,50 e 0,75 g m-3) foi o que se objetivou através deste trabalho.
Lêda R. D. Faroni, Pedro A. Berbert, Ana P. Martinazzo, Enilce M. Coelho   +3 more
doaj   +1 more source

Atmospheric pressure plasma jet in controlled atmosphere: electric fields and propagation dynamics

Plasma Sources Science and Technology, 2018
We investigate the influence of the surrounding gas on the behaviour of guided ionization waves by measuring the electric field, propagation dynamics and emission spectra of a kHz operated helium plasma jet in surrounding gases such as nitrogen, oxygen and dry air.
Serajoddin Razavizadeh, Hamid Ghomi, Ana Sobota   +2 more
openaire   +2 more sources