Results 101 to 110 of about 2,358,784 (358)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

High-entropy layered double hydroxide nanosheets reprogram tumor homeostasis for ultrasound-enhanced pyroptosis-mediated immunotherapy

Journal of Nanobiotechnology
Developing redox nanozymes able to disrupt cellular homeostasis and promoting immunotherapy offers great potentials to develop highly efficient cancer therapy, but remains challenging.
Xueting Yang, Manman Xu, Yashuo Jiang, Xiangling Gu, Chao Zhu, Yaqing Ge, Jing Li, Zheng Mo, Hongbin Qi, Xiaofei Liu   +9 more
doaj   +1 more source

Remotely triggered scaffolds for controlled release of pharmaceuticals [PDF]

, 2013
Fe3O4-Au hybrid nanoparticles (HNPs) have shown increasing potential for biomedical applications such as image guided stimuli responsive drug delivery.
Hoskins, Clare, Lees, Martin R., McGarvey, David J., Roach, Paul, Ph.D.   +3 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Doxorubicin delivery by pYEEIE peptide-functionalized rhodiola rosea-derived exosome-like nanovesicles for targeted melanoma therapy

Frontiers in Pharmacology
IntroductionMelanoma is the most common cause of skin cancer-related deaths due to its aggressive nature. Plant-derived exosome-like nanovesicles (PELNs) are promising natural nanoparticles for therapeutic applications owing to their biocompatibility and
Meitao Duan, Binbin Chen, Xue Yi, Ahmed Mahal, Linwei Song, Moxun Xu, Ahmad J. Obaidullah, Shuwei Yu, Chen Wang, Chen Wang   +9 more
doaj   +1 more source

Design and testing of hydrophobic core/hydrophilic shell nano/micro particles for drug-eluting stent coating [PDF]

, 2018
In this study, we designed a novel drug-eluting coating for vascular implants consisting of a core coating of the anti-proliferative drug docetaxel (DTX) and a shell coating of the platelet glycoprotein IIb/IIIa receptor monoclonal antibody SZ-21.
A Arsiwala, A Bierhalz, A Tan, AW Heldman, B Almería, B O’brien, B O’Brien, C Stettler, CJ Pan, CJ Sweeney, CL Song, D Sun, DM Saylor, E Boersma, E Camenzind, ES Park, ES Thian, F Danhier, GY An, H Zhang, HG Wang, J Kanzer, J Riegger, J Yang, J Zhang, JB Slee, JJ Wykrzykowska, JM Lee, JV Natarajan, K Kolandaivelu, KH Bønaa, KS Lim, M Gawaz, M Zamani, M Zamani, MK Dong, MP Skinner, MT Ali, PS Douglas, PW Erruys, RH Müller, RK Aggarwal, RL Wilensky, S Freiberg, S Garg, S Hossfeld, S Jang, S Lee, S Mcginty, S Meng, S Puricel, S Yasuda, SJ Liu, T Inoue, T Nakano, TM Ko, U Baber, X Ma, X Wu, X Xi, Y Cao, YH Lee, Z Yang   +62 more
core   +1 more source

A polymer hybrid film based on poly(vinyl cinnamate) and poly(2-hydroxy ethyl methacrylate) for controlled flurbiprofen release [PDF]

, 2021
Mamoon Alokour, Elvan Yılmaz
openalex   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Chemically cross-linked poly(acrylic-co-vinylsulfonic) acid hydrogel for the delivery of isosorbide mononitrate. [PDF]

, 2013
We report synthesis, characterization, and drug release attributes of a series of novel pH-sensitive poly(acrylic-co-vinylsulfonic) acid hydrogels.
Ansari, Mahvash, Hussain, Talib, Khan, Ikram Ullah, Ranjha, Nazar Muhammad, Shahzad, Yasser   +4 more
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source