Results 241 to 250 of about 2,314,627 (288)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Antiosteolytic Bisphosphonate Metallodrug Coordination Networks: Dissolution Profiles and <i>In Vitro/In Vivo</i> Toxicity toward Controlled Release. [PDF]

ACS Appl Bio Mater
Chachlaki E, Vassaki M, Turhanen PA, Choquesillo-Lazarte D, Banti CN, Hadjikakou SK, Demadis KD.   +6 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Starch Hydrogels for Slow and Controlled-Release Fertilizers: A Review. [PDF]

Polymers (Basel)
Chamorro AF, Palencia M, Combatt EM.
europepmc   +1 more source

Controlled-Release Hydromorphone

, 2022
Nauck, Friedemann, Ostgathe, C., Dickerson, E. D., Klaschik, E.   +3 more
openaire   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Synergistic co-delivery of curcumin and N-acetylneuraminate via bigel: Enhanced stability, antioxidant performance, and controlled release during in vitro digestion. [PDF]

Food Chem X
Qian Y, Xu L, Li M, Chen X, Chen J, Cai K, Cao L, Pang M.   +7 more
europepmc   +1 more source

Photosensitizing systems based on alginate aerogels and methylene blue for controlled release of dye for antimicrobial photodynamic therapy. [PDF]

Front Chem
Shershnev I, Solovieva A, Kopylov A, Cherkasova A, Kaplin V, Rachev S, Kuryanova A, Aksenova N, Timofeeva V, Akovantseva A, Zarkhina T, Shantarovich V, Bekeshev V, Bikmulina P, Huang RL, Li Q, Timashev P.   +16 more
europepmc   +1 more source

The future of herbicide application: controlled-release formulations for enhanced agricultural sustainability. [PDF]

Des Monomers Polym
Luhach V, Yadav J, Barala P, Sangwan P, Suhag S, Hooda V.   +5 more
europepmc   +1 more source

Polydopamine-Coated Poly(l-lactide) Nanofibers with Controlled Release of IL-10 for Effective Management of Peripheral and Central Neuropathic Pain in Rats. [PDF]

ACS Biomater Sci Eng
Zhao J, Xue T, Liu Z.
europepmc   +1 more source