Results 81 to 90 of about 409,392 (349)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Global norms, organizational action: Leveraging international children’s rights law to advance child safeguarding

Leiden Journal of International Law
Tragically, the abuse of children within organizational contexts continues to persist across time and geographies. Various institutions established for children’s care and protection have repeatedly been exposed as epicentres of abuse.
Afrooz Kaviani Johnson
doaj   +1 more source

Comparative Study of the Right to Education of Children from the perspective of the Convention on the Rights of the Child and the Constitutional Law of Iran [PDF]

حقوق عمومی تطبیقی
The right to education is one of the basic and fundamental rights that is considered among the basic human rights. This right has been emphasized at the global level under conventions, international covenants, the Universal Declaration of Human Rights ...
Milad Kashi Komijani, mahdi rajaei
doaj   +1 more source

Made by Children: the Exploitation of Child Labour in Agriculture, Industry and the Service Sector in Mainland China [PDF]

, 2017
This research essay examines the exploitation of child labour in agriculture, industry and the service sector in Mainland China. Child productivity in China has historically been essential to the survival of the family.
Nguyen, C. (Cindy)
core  

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

What does the best interests principle of the convention on the rights of the child mean for paediatric healthcare? [PDF]

Eur J Pediatr, 2022
März JW.
europepmc   +1 more source

From International Mandate to National Legislation: Pakistan’s Response to Erga Omnes Obligations on Child Sexual Abuse

Journal of Legal Studies
This article critically assesses Pakistan’s compliance with erga omnes obligations under the Convention on the Rights of the Child (CRC) concerning sexual abuse of children.
Ali Muhammad Imran
doaj   +1 more source

Children’s rights and needs during war: the case of adolescents in Israel

Frontiers in Psychology
IntroductionThis study aims to examine the attainment of rights and needs of adolescents during the war following the October 7th 2023 terror attack on Israel.
Yonat Rum, Erez Milsthen, Heba F. Zedan, Tali Gal   +3 more
doaj   +1 more source

RATIFIKASI KONVENSI TENTANG HAK-HAK ANAK DALAM SISTEM PERATURAN PERUNDANG-UNDANGAN DI INDONESIA

Yuridika, 2017
The Convention on the Rights of the Child (CRC) is the most comprehensive human rights treaty and legal instrument for the promotion and protection of children’s rights.
Zendy Wulan Ayu Widhi Prameswari
doaj   +1 more source