Results 61 to 70 of about 273,946 (300)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Development of a total Lagrangian SPH code for the simulation of solids under dynamioc loading [PDF]

, 2007
This thesis makes use of an alternative SPH formulation, the Total Lagrangianf ormulation, to characterised ynamic eventsi n solids and to achieve the proposed objectives outlined in Chapter 1.
Reveles, Juan R.
core  

Improving the performance of concrete using 3D fibres

, 2012
This paper examines whether 3D fibre reinforcement can improve the toughness and flexural strength of concrete, when compared to equal dosage of straight steel fibres. This work was carried out to determine structural qualities that may lead to potential
Richardson, Alan, Heather, Marcus
core   +1 more source

Recent advances in dental implants

Maxillofacial Plastic and Reconstructive Surgery, 2017
Dental implants are a common treatment for the loss of teeth. This paper summarizes current knowledge on implant surfaces, immediate loading versus conventional loading, short implants, sinus lifting, and custom implants using three-dimensional printing.
Do Gia Khang Hong, Ji-hyeon Oh
doaj   +1 more source

Impact of dissolved oxygen and loading rate on NH3 oxidation and N2 production mechanisms in activated sludge treatment of sewage

Microbial Biotechnology, 2021
Summary Microaerobic activated sludge (MAS) is a one‐stage process operated at 0.5–1.0 mg l−1 dissolved oxygen (DO) aiming at simultaneous nitrification and denitrification.
Xueyu Zhang, Shida Li, Shaokui Zheng, Shoupeng Duan   +3 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Graded conventional-auxetic Kirigami sandwich structures:Flatwise compression and edgewise loading

, 2014
The work describes the manufacturing and testing of graded conventional/auxetic honeycomb cores. The graded honeycombs are manufactured using Kevlar woven fabric/914epoxy prepreg using Kirigami techniques, which consist in a combination of Origami and ...
R. Neville, Neville, Robin M, Gu, B., Y. Hou, M. Ruzzene, B. Gu, Hou, Yangqing, Ruzzene, Massimo, F. Scarpa, C. Remillat, Remillat, Chrystel D L, Scarpa, Fabrizio   +11 more
core   +1 more source