Results 71 to 80 of about 273,946 (300)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Comparing the effect of off-loading knee brace with and without local muscle vibration on clinical and biomechanical outcomes in patients with medial knee osteoarthritis: A randomized clinical trial

Journal of Rehabilitation and Assistive Technologies Engineering
Background Medial knee osteoarthritis (KOA) is a prevalent degenerative joint disease causing pain and functional impairment. Off-loading knee braces reduce pain but may decrease muscle activity, leading to weakness.
Mahsa Zangi, Mahmood Bahramizadeh, Mobina Khosravi, Farzam Farahmand, Mokhtar Arazpour PhD, Koorosh Barati   +5 more
doaj   +1 more source

Structural Behaviour of Slab-on-Grade Constructed Using High-Ductility Fiber-Reinforced Cement Composite: Experimental and Analytical Investigation

Fibers
This study investigated the structural behavior of slab-on-grade (SOG) specimens constructed using two materials: conventional concrete reinforced with steel mesh and high-ductility fiber-reinforced cement composites (HDFRCC) containing 1.2% polyethylene
Su-Tae Kang, Nilam Adsul, Bang Yeon Lee
doaj   +1 more source

Single specimen repeated loading method for determination of residual strength parameters of rock

Yantu gongcheng xuebao, 2019
Based on the single test method and the deformation characteristics of residual phase of rock, a single specimen repeated loading method is proposed to measure the residual strength parameters of the rock.
DENG Hua-feng , ZHANG Heng-bin , LI Jian-lin , DUAN Ling-ling , ZHI Yong-yan , PAN Deng
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Numerical simulation of conventional RC columns under concentric loading

, 2009
This paper aims to explore the correct prediction of stress-strain behavior and the determination of load ratio of conventional reinforced concrete (RC) columns subjected to concentric loading. Although there are numerous empirical confinement models are
Doran, Bilge
core   +1 more source

Seismic enhancement of RC exterior beam-column joints using Ultra High Performance Concrete layers

Journal of Applied Science and Engineering
This paper presents an in-depth study of the structural behavior of exterior beam-column joints retrofitted with Ultra High Performance Concrete (UHPC) under reversed cyclic loading.
Viet Chinh Mai, Van Tu Nguyen, Xuan Dai Nguyen   +2 more
doaj   +1 more source

Standardized sign conventions and notation for generally loaded foundations

Géotechnique, 1997
There has recently been increasing research on the classical geotechnical problem of the load-displacement response of rigid shallow foundations under general loading conditions. Most of the published experimental data and mathematical models relate to the problem's two-dimensional version, where a footing of given breadth supports given vertical and ...
Butterfield, R, Houlsby, G, Gottardi, G
openaire   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source