Results 51 to 60 of about 1,296,348 (280)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Approximation of functions of two variables by certain linear positive operators

open access: yes, 2007
We introduce certain linear positive operators and study some approximation properties of these operators in the space of functions, continuous on a compact set, of two variables.
Bascanbaz-Tunca, Gulen   +2 more
core   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

On Consistency of Operational Transformation Approach

open access: yes, 2013
The Operational Transformation (OT) approach, used in many collaborative editors, allows a group of users to concurrently update replicas of a shared object and exchange their updates in any order.
Boucheneb, Hanifa   +3 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

(Quasi)-uniformities on the set of bounded maps

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 1994
From real analysis it is known that if a sequence {fn,   n∈ℕ} of real-valued functions defined and bounded on X⊂ℝ converges uniformly to f, then f is also bounded and the sequence {fn,   n∈ℕ}. In the present paper we generalize results as the above using
Basil K. Papadopoulos
doaj   +1 more source

About Some Monge–Kantovorich Type Norm and Their Applications to the Theory of Fractals

open access: yesMathematics, 2022
If X is a Hilbert space, one can consider the space cabv(X) of X valued measures defined on the Borel sets of a compact metric space, having a bounded variation. On this vector measures space was already introduced a Monge–Kantorovich type norm.
Ion Mierluș-Mazilu, Lucian Niță
doaj   +1 more source

Convergence of the cascade algorithm at irregular scaling functions

open access: yes, 1999
The spectral properties of the Ruelle transfer operator which arises from a given polynomial wavelet filter are related to the convergence question for the cascade algorithm for approximation of the corresponding wavelet scaling function.Comment: AMS ...
Bratteli, Ola, Jorgensen, Palle E. T.
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

The Polynomial Pivots as Initial Values for a New Root-Finding Iterative Method

open access: yesJournal of Applied Mathematics, 2015
A new iterative method for polynomial root-finding based on the development of two novel recursive functions is proposed. In addition, the concept of polynomial pivots associated with these functions is introduced.
Mario Lázaro   +3 more
doaj   +1 more source

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